Reviewed, UniProtKB/Swiss-Prot Q492L1 (SYD_BLOPB)

Names and origin

Protein names

Recommended name:
    Aspartyl-tRNA synthetase
    EC=6.1.1.12
Alternative name(s):
    Aspartate--tRNA ligase
      Short name=AspRS

Gene names

Name:	aspS
Ordered Locus Names:	BPEN_467

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	574 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00044
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP aspartate-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 574	574	Aspartyl-tRNA synthetase HAMAP MF_00044		PRO_0000235509

Sequences

	Sequence		Length	Mass (Da)
	Q492L1-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 4DBCFE93C0CD6A0F	FASTA	574	66,034
	10 20 30 40 50 60 MRTAYCGQLN LSHVGLEVTL CGWINKYRNF GGLIFIDLRD REGCIQVCFD VYQNKEVCIS 70 80 90 100 110 120 AAKLKQEFCI QLIGMVRARP KNQINSNIST GAVEVVAKKF SILNISDPLP LDISKNNIEE 130 140 150 160 170 180 NRLKYRYLDL RRSIMFDRIK TRSRIMSIVH RFMELEGFLN IETPMLTKVT PEGSRDYIVP 190 200 210 220 230 240 SRLHAGKNYA LPQSPQIFKQ LLMVSGFDRY YQITKCFRDE DLRADRQPEF TQIDIETSFM 250 260 270 280 290 300 TTQKIRELME IFIRIIWREI LNVELGVFSQ FTYSEVMQRF GSDAPDLRNP IEMFDVSYLF 310 320 330 340 350 360 NSTQNRLSFI RANNIGVQAI AMKVPNGRQL TQKQIDEYIY YSKQCGLKEL LWVKVQFSDN 370 380 390 400 410 420 DITKKEIQGS VTNFIDNLTL DIILNKTNIK SNDILFVGFN DNKNQFITKM LSALRLKLGN 430 440 450 460 470 480 DLCLIKKDSW APLWIIDFPM FKKNCHGEYT SMHHMFTSPK NCDVQMLKKD PLLVISEAYD 490 500 510 520 530 540 MVINGCEIGS GSARIHSFDM QQAVFNILGI TQNDQKKKFG YFMDALKYGA PPHAGLAFGL 550 560 570 DRIAMLLTGS KNIREVIAFP KTTASVDIMA NAPD

References

[1]	"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000016 Genomic DNA. Translation: AAZ41086.1.
RefSeq	YP_277962.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3562963.
GenomeReviews	Gene locus BPEN_467 in contig CP000016_GR.
KEGG	bpn:BPEN_467.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q492L1.
OMA	Q492L1. VDRRRDH.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_467-MON.
Family and domain databases
HAMAP	MF_00044. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-reg. IPR002312. Asp-tRNA-synth_IIb. IPR004524. Asp-tRNA-synth_IIb_bac/mt. IPR018153. Asp-tRNA-synth_IIb_C_bac/mt. IPR004115. GAD. IPR012340. NA-bd_OB-fold. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF5. AspS_bac. 1 hit.
Pfam	PF02938. GAD. 1 hit. PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00459. aspS_bact. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYD_BLOPB

Accession

Primary (citable) accession number: Q492L1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)