Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q492K3 (HISX_BLOPB)

Last modified November 25, 2008. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Histidinol dehydrogenase
      Short name=HDH
    EC=1.1.1.23
Gene names
Name: hisD
Ordered Locus Names: BPEN_478
OrganismBlochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]
Taxonomic identifier291272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Hide | Top

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.

Catalytic activity

L-histidinol + 2 NAD(+) = L-histidine + 2 NADH. HAMAP MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Histidinol dehydrogenase HAMAP MF_01024
PRO_0000135735

Sites

Active site3291Proton acceptor By similarity
Active site3301Proton acceptor By similarity
Metal binding2621Zinc By similarity
Metal binding2651Zinc By similarity
Metal binding3631Zinc By similarity
Metal binding4221Zinc By similarity
Binding site1331NAD By similarity
Binding site1911NAD By similarity
Binding site2141NAD By similarity
Binding site2401Substrate By similarity
Binding site2621Substrate By similarity
Binding site2651Substrate By similarity
Binding site3301Substrate By similarity
Binding site3631Substrate By similarity
Binding site4171Substrate By similarity
Binding site4221Substrate By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q492K3-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: E08D5771184EE9F4

FASTA44349,150
        10         20         30         40         50         60 
MISHEHPISI YWNDCSKSEQ KKLLTRPINN KLNDIYINVK NILTKVYNEG DRALFKFNFD 

        70         80         90        100        110        120 
FDNVQTTQLQ IPTEIIMNSG RNLSNEIKQA IHTAMTNITR FHQAQCYSEI IVETLPGVYC 

       130        140        150        160        170        180 
QQIIRPLNIV GLYVPGGTAP LLSTVMMLGV PARIAKCKRV ILCSPPPIPD VIIYTAQLCG 

       190        200        210        220        230        240 
IDEIYQIGGS QSIAAMGFGT ESIPKVDKIF GPGNIWVTEA KRQINLAPNG AAIDMLAGPS 

       250        260        270        280        290        300 
EILIIADNTA NPIFIAADLL SQSEHGPDSH AILITPYSCI AEKTKKELHK QLKILPRNDI 

       310        320        330        340        350        360 
VRNVLLNSRM IITNNLMECF SISNSYAPEH LIIQIENASD YLHYITNAGS IFLGNWSPET 

       370        380        390        400        410        420 
AGDYASGPNH VLPTYGRAVA TSGLGVIDFQ KRMSVQQLTQ NGLLQLSSTI TTLTQIEQLK 

       430        440 
AHEYAITHRI NYIKEQNEHS LLG

« Hide

Hide | Top

References

[1]"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
Degnan P.H., Lazarus A.B., Wernegreen J.J.
Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Hide | Top

Cross-references

Sequence databases

CP000016 Genomic DNA. Translation: AAZ41094.1.
RefSeqYP_277970.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3562985.
GenomeReviewsGene locus BPEN_478 in contig CP000016_GR.
KEGGbpn:BPEN_478.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ492K3.

Enzyme and pathway databases

BioCycCBLO291272:BPEN_478-MON.

Family and domain databases

HAMAPMF_01024.
[Tree]
InterProIPR001692. Histidinol_DHase.
IPR012131. Hstdl_DHase_prok.
[Graphical view]
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSPR00083. HOLDHDRGNASE.
ProDomPD002680. Histidinol_dh. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameHISX_BLOPB
AccessionPrimary (citable) accession number: Q492K3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents