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Q492K3

- HISX_BLOPB

UniProt

Q492K3 - HISX_BLOPB

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Blochmannia pennsylvanicus (strain BPEN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei133 – 1331NADUniRule annotation
    Binding sitei191 – 1911NADUniRule annotation
    Binding sitei214 – 2141NADUniRule annotation
    Binding sitei240 – 2401SubstrateUniRule annotation
    Metal bindingi262 – 2621ZincUniRule annotation
    Binding sitei262 – 2621SubstrateUniRule annotation
    Metal bindingi265 – 2651ZincUniRule annotation
    Binding sitei265 – 2651SubstrateUniRule annotation
    Active sitei329 – 3291Proton acceptorUniRule annotation
    Active sitei330 – 3301Proton acceptorUniRule annotation
    Binding sitei330 – 3301SubstrateUniRule annotation
    Metal bindingi363 – 3631ZincUniRule annotation
    Binding sitei363 – 3631SubstrateUniRule annotation
    Binding sitei417 – 4171SubstrateUniRule annotation
    Metal bindingi422 – 4221ZincUniRule annotation
    Binding sitei422 – 4221SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:BPEN_478
    OrganismiBlochmannia pennsylvanicus (strain BPEN)
    Taxonomic identifieri291272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
    ProteomesiUP000007794: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Histidinol dehydrogenasePRO_0000135735Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi291272.BPEN_478.

    Structurei

    3D structure databases

    ProteinModelPortaliQ492K3.
    SMRiQ492K3. Positions 10-436.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiQKSLHAV.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q492K3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISHEHPISI YWNDCSKSEQ KKLLTRPINN KLNDIYINVK NILTKVYNEG    50
    DRALFKFNFD FDNVQTTQLQ IPTEIIMNSG RNLSNEIKQA IHTAMTNITR 100
    FHQAQCYSEI IVETLPGVYC QQIIRPLNIV GLYVPGGTAP LLSTVMMLGV 150
    PARIAKCKRV ILCSPPPIPD VIIYTAQLCG IDEIYQIGGS QSIAAMGFGT 200
    ESIPKVDKIF GPGNIWVTEA KRQINLAPNG AAIDMLAGPS EILIIADNTA 250
    NPIFIAADLL SQSEHGPDSH AILITPYSCI AEKTKKELHK QLKILPRNDI 300
    VRNVLLNSRM IITNNLMECF SISNSYAPEH LIIQIENASD YLHYITNAGS 350
    IFLGNWSPET AGDYASGPNH VLPTYGRAVA TSGLGVIDFQ KRMSVQQLTQ 400
    NGLLQLSSTI TTLTQIEQLK AHEYAITHRI NYIKEQNEHS LLG 443
    Length:443
    Mass (Da):49,150
    Last modified:September 13, 2005 - v1
    Checksum:iE08D5771184EE9F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000016 Genomic DNA. Translation: AAZ41094.1.
    RefSeqiYP_277970.1. NC_007292.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ41094; AAZ41094; BPEN_478.
    GeneIDi3562985.
    KEGGibpn:BPEN_478.
    PATRICi31965874. VBICanBlo110049_0466.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000016 Genomic DNA. Translation: AAZ41094.1 .
    RefSeqi YP_277970.1. NC_007292.1.

    3D structure databases

    ProteinModelPortali Q492K3.
    SMRi Q492K3. Positions 10-436.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 291272.BPEN_478.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ41094 ; AAZ41094 ; BPEN_478 .
    GeneIDi 3562985.
    KEGGi bpn:BPEN_478.
    PATRICi 31965874. VBICanBlo110049_0466.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi QKSLHAV.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
      Degnan P.H., Lazarus A.B., Wernegreen J.J.
      Genome Res. 15:1023-1033(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BPEN.

    Entry informationi

    Entry nameiHISX_BLOPB
    AccessioniPrimary (citable) accession number: Q492K3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3