ID   TRUA_BLOPB              Reviewed;         261 AA.
AC   Q492H3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=tRNA pseudouridine synthase A;
DE            EC=5.4.99.12;
DE   AltName: Full=tRNA-uridine isomerase I;
DE   AltName: Full=tRNA pseudouridylate synthase I;
GN   Name=truA; OrderedLocusNames=BPEN_512;
OS   Blochmannia pennsylvanicus (strain BPEN).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; ant endosymbionts; Candidatus Blochmannia.
OX   NCBI_TaxID=291272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16077009; DOI=10.1101/gr.3771305;
RA   Degnan P.H., Lazarus A.B., Wernegreen J.J.;
RT   "Genome sequence of Blochmannia pennsylvanicus indicates parallel
RT   evolutionary trends among bacterial mutualists of insects.";
RL   Genome Res. 15:1023-1033(2005).
CC   -!- FUNCTION: Formation of pseudouridine at positions 38, 39 and 40 in
CC       the anticodon stem and loop of transfer RNAs (By similarity).
CC   -!- CATALYTIC ACTIVITY: tRNA uridine = tRNA pseudouridine.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase truA
CC       family.
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DR   EMBL; CP000016; AAZ41126.1; -; Genomic_DNA.
DR   RefSeq; YP_278003.1; -.
DR   GeneID; 3563029; -.
DR   GenomeReviews; CP000016_GR; BPEN_512.
DR   KEGG; bpn:BPEN_512; -.
DR   HOGENOM; Q492H3; -.
DR   OMA; Q492H3; RRYRYTI.
DR   BioCyc; CBLO291272:BPEN_512-MON; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:HAMAP.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:HAMAP.
DR   HAMAP; MF_00171; -; 1.
DR   InterPro; IPR001406; tRNA_psdUrid_synth.
DR   Gene3D; G3DSA:3.30.70.580; PseudoU_synth_1; 1.
DR   Gene3D; G3DSA:3.30.70.660; PseudoU_synth_1; 1.
DR   PANTHER; PTHR11142; PseudoU_synth_1; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 2.
DR   PIRSF; PIRSF001430; tRNA_psdUrid_synth; 1.
DR   TIGRFAMs; TIGR00071; hisT_truA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; tRNA processing.
FT   CHAIN         1    261       tRNA pseudouridine synthase A.
FT                                /FTId=PRO_1000017042.
FT   ACT_SITE     52     52       Nucleophile (By similarity).
FT   BINDING     110    110       Substrate (By similarity).
FT   BINDING     237    237       Substrate (By similarity).
SQ   SEQUENCE   261 AA;  29944 MW;  730C1965E2E440B5 CRC64;
     MQKLALGIEY DGSWYCGWQR QRDAPSIQSY IENAIKKITS ESVTVFCAGR TDSGVHALGQ
     VVHFETYSRR SKSAWTLGMN RYLPSSICVR WARLVNKDFH ARFSAISRRY CYIINNNCIR
     SALLFRKTWH YKKYLDINKM CDAAQYLLGE NDFSSFRAAG CQSYSARRKL YHIRIIRKGQ
     CIVIDIKANS FMYRMVRNIV GSLVKVGCGE QPEKWIAELL ENCNRSLAGV TAPASGLYLV
     EVKYPSDFSI PSSFIEELWC A
//