Reviewed, UniProtKB/Swiss-Prot Q492E1 (SYH_BLOPB)

Names and origin

Protein names

Recommended name:
    Histidyl-tRNA synthetase
    EC=6.1.1.21
Alternative name(s):
    Histidine--tRNA ligase
      Short name=HisRS

Gene names

Name:	hisS
Ordered Locus Names:	BPEN_550

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP MF_00127
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00127
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP histidine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	Histidyl-tRNA synthetase HAMAP MF_00127		PRO_0000136116

Sequences

	Sequence		Length	Mass (Da)
	Q492E1-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 2FCC04C213FDB1E0	FASTA	438	50,693
	10 20 30 40 50 60 MLKYDKNIQS VRGMHDYLPK DTILWQYIEN ILITILDSYG YKEIRFPIIE DTNLFKRSIG 70 80 90 100 110 120 EVTDVIEKEM YNFTDRNGNN LTLRPEGTSG CVRAGIKHGL FYHQEQRLWY LGPMFRYERP 130 140 150 160 170 180 QKGRYRQFHQ FSAEAFGQIG PDIDAELILI TARCWKKLGI NHHLSLELNS IGSLSSRINY 190 200 210 220 230 240 RKKLITFLEK NLSNLDSNAL RRLYSNPLRI LDTKNTKTKE LLLNAPILSD YLDDDSRVHF 250 260 270 280 290 300 SELCQLLNLL GVPYRVNPYL VRGLDYYNKT VFEWVTDSLG VKKTICAGGR YDELVQELGG 310 320 330 340 350 360 YSAPAIGFSI GLERVILLIQ EINNISILHK NIYIDVYFIS IGDNSRKHAM LLSENIRSTL 370 380 390 400 410 420 PSLRLMVHHG GDDIKKQFYC ANKHKPQIVL IMNEKNALDK TIILKNLQSK TQEILKHDAV 430 SERLKHILHI TCNSTDNK

References

[1]	"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000016 Genomic DNA. Translation: AAZ41160.1.
RefSeq	YP_278037.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3562940.
GenomeReviews	Gene locus BPEN_550 in contig CP000016_GR.
KEGG	bpn:BPEN_550.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q492E1.
OMA	Q492E1. VFEWVTT.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_550-MON.
Family and domain databases
HAMAP	MF_00127. [Tree]
InterPro	IPR002314. aa-tRNA-synt_IIb_cons-reg. IPR006195. aa-tRNA-synth_II_cons-reg. IPR004154. Anticodon_bd. IPR015807. His-tRNA-synth_IIa_sub. IPR004516. His-tRNA_synth_IIA. [Graphical view]
Gene3D	G3DSA:3.40.50.800. Anticodon_bd. 1 hit.
PANTHER	PTHR11476. His-tRNA_synth. 1 hit.
Pfam	PF03129. HGTP_anticodon. 1 hit. PF00587. tRNA-synt_2b. 1 hit. [Graphical view]
PIRSF	PIRSF001549. His-tRNA_synth. 1 hit.
TIGRFAMs	TIGR00442. hisS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYH_BLOPB

Accession

Primary (citable) accession number: Q492E1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)