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Protein

NAD kinase

Gene

nadK

Organism
Blochmannia pennsylvanicus (strain BPEN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74Proton acceptorUniRule annotation1
Binding sitei79NADUniRule annotation1
Binding sitei176NADUniRule annotation1
Binding sitei178NADUniRule annotation1
Binding sitei248NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 75NADUniRule annotation2
Nucleotide bindingi148 – 149NADUniRule annotation2
Nucleotide bindingi189 – 194NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBLO291272:G1G3Y-562-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:BPEN_565
OrganismiBlochmannia pennsylvanicus (strain BPEN)
Taxonomic identifieri291272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
Proteomesi
  • UP000007794 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296121 – 297NAD kinaseAdd BLAST297

Interactioni

Protein-protein interaction databases

STRINGi291272.BPEN_565

Structurei

3D structure databases

ProteinModelPortaliQ492C6
SMRiQ492C6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR000595 cNMP-bd_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q492C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSIFRTIG IIGYSRHPKA VHTYDILYHW LYSKGITVII EHHAASLLNV
60 70 80 90 100
QKAVVGDLND IGNYADLAIV IGGDGNMLRA ANILAQHDIK VIGINRGTLG
110 120 130 140 150
FLTDLDPNSA LVELSDVLSG HFINEKRFLL DVTVQRYNKL IRLGSAINEV
160 170 180 190 200
ILHTNTIRDM IEFELYIDDN FIFSQRSDGL IISTPTGSTA YALSAGGPIL
210 220 230 240 250
SPTVDAILLV PICPHTLSSR PVVINSKSII CLKFSKVTSE LKIGYDNQTP
260 270 280 290
VLVCKEEEIF IKRSNHYLDL IHPNNYNYFK TLNIKLGWSQ NIAETKK
Length:297
Mass (Da):33,048
Last modified:September 13, 2005 - v1
Checksum:i38CFFD72729629FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000016 Genomic DNA Translation: AAZ41175.1
RefSeqiWP_011283086.1, NC_007292.1

Genome annotation databases

EnsemblBacteriaiAAZ41175; AAZ41175; BPEN_565
KEGGibpn:BPEN_565

Similar proteinsi

Entry informationi

Entry nameiNADK_BLOPB
AccessioniPrimary (citable) accession number: Q492C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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