Reviewed, UniProtKB/Swiss-Prot Q492A5 (AROB_BLOPB)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	BPEN_591

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000231070

Sequences

	Sequence		Length	Mass (Da)
	Q492A5-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: C8C741FECDBE0037	FASTA	362	40,279
	10 20 30 40 50 60 MEKIIIKLEK RSYPIIIADK LFNDFLPFWP LNIDDKVVLI TNDRVAPIYL NILRNLLIRS 70 80 90 100 110 120 GIVTDQLILP DGEQNKSLIT LDTIFTKLLK KNYDRSTILI GLGGGVIGDI TGFAAATYQR 130 140 150 160 170 180 GIRFIQVPTT LLAQVDASIG GKTGINHILG KNMIGAFHQP IAVIINLDVL HTLSMKEFSS 190 200 210 220 230 240 GLAEIIKYAI ALDSSFFGWL ESHLDDLLIL HLPSLMYCIR RCCELKASII AIDERDQGIR 250 260 270 280 290 300 SVLNLGHTYG HAIESYLGYS QWSHGESIAA GIMMAVNTAL RLNQFNCSDA KRIKLLLTRA 310 320 330 340 350 360 GLPVRGPKEM TSKNYLEYMK RDKKSISGQL NLVLPTSTIG NVKTVFNVNH ELVSLSIEDT NN

References

[1]	"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000016 Genomic DNA. Translation: AAZ41197.1.
RefSeq	YP_278074.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q492A5.
Genome annotation databases
GeneID	3563064.
GenomeReviews	Gene locus BPEN_591 in contig CP000016_GR.
KEGG	bpn:BPEN_591.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q492A5.
OMA	EDYLPHM.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_591-MON.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BLOPB

Accession

Primary (citable) accession number: Q492A5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)