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Q492A5 (AROB_BLOPB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:BPEN_591
OrganismBlochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]
Taxonomic identifier291272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3623623-dehydroquinate synthase HAMAP MF_00110
PRO_0000231070

Sequences

Sequence LengthMass (Da)Tools
Q492A5 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: C8C741FECDBE0037

FASTA36240,279
        10         20         30         40         50         60 
MEKIIIKLEK RSYPIIIADK LFNDFLPFWP LNIDDKVVLI TNDRVAPIYL NILRNLLIRS 

        70         80         90        100        110        120 
GIVTDQLILP DGEQNKSLIT LDTIFTKLLK KNYDRSTILI GLGGGVIGDI TGFAAATYQR 

       130        140        150        160        170        180 
GIRFIQVPTT LLAQVDASIG GKTGINHILG KNMIGAFHQP IAVIINLDVL HTLSMKEFSS 

       190        200        210        220        230        240 
GLAEIIKYAI ALDSSFFGWL ESHLDDLLIL HLPSLMYCIR RCCELKASII AIDERDQGIR 

       250        260        270        280        290        300 
SVLNLGHTYG HAIESYLGYS QWSHGESIAA GIMMAVNTAL RLNQFNCSDA KRIKLLLTRA 

       310        320        330        340        350        360 
GLPVRGPKEM TSKNYLEYMK RDKKSISGQL NLVLPTSTIG NVKTVFNVNH ELVSLSIEDT 


NN

« Hide

References

[1]"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects."
Degnan P.H., Lazarus A.B., Wernegreen J.J.
Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BPEN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000016 Genomic DNA. Translation: AAZ41197.1.
RefSeqYP_278074.1. NC_007292.1.

3D structure databases

ProteinModelPortalQ492A5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ492A5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3563064.
GenomeReviewsGene locus BPEN_591 in contig CP000016_GR.
KEGGbpn:BPEN_591.
PATRIC31966105. VBICanBlo110049_0573.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBQ492A5.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycCBLO291272:BPEN_591-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BLOPB
AccessionPrimary (citable) accession number: Q492A5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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