Reviewed, UniProtKB/Swiss-Prot Q492A4 (AROK_BLOPB)

Names and origin

Protein names

Recommended name:
    Shikimate kinase
      Short name=SK
    EC=2.7.1.71

Gene names

Name:	aroK
Ordered Locus Names:	BPEN_592

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity. HAMAP MF_00109
Catalytic activity	ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00109
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00109
Subunit structure	Monomer By similarity. HAMAP MF_00109
Subcellular location	Cytoplasm Probable HAMAP MF_00109.
Sequence similarities	Belongs to the shikimate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro shikimate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	Shikimate kinase HAMAP MF_00109		PRO_0000237848
Regions
	Nucleotide binding	23 – 28	6	ATP By similarity
Sites
	Metal binding	27	1	Magnesium By similarity
	Binding site	45	1	Substrate By similarity
	Binding site	69	1	Substrate By similarity
	Binding site	91	1	Substrate; via amide nitrogen By similarity
	Binding site	129	1	ATP By similarity
	Binding site	152	1	Substrate By similarity
	Binding site	169	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q492A4-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 4523DC521DD3B722	FASTA	187	21,384
	10 20 30 40 50 60 MKKSFSYNNM LKKNNIFLIG PMGAGKSTIG RQLANQLNME FFDSDQEIET RTGANISWVF 70 80 90 100 110 120 DVEGEERFRD REEKIIDELT KKQGIILATG GGSVKSHITR NNLSDRGFVV YLETTIEKQL 130 140 150 160 170 180 IRTQHDKRRP LLRSSSASGN TRDLLQVLAK ERNPLYEEIA DIRISTDEQN VRVVVNKIII LRKKSSL

References

[1]	"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000016 Genomic DNA. Translation: AAZ41198.1.
RefSeq	YP_278075.1.
3D structure databases
SMR	Q492A4. Positions 12-179.
ModBase	Search...
Protein-protein interaction databases
STRING	Q492A4.
Genome annotation databases
GeneID	3563065.
GenomeReviews	Gene locus BPEN_592 in contig CP000016_GR.
KEGG	bpn:BPEN_592.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0703.
HOGENOM	HBG335815.
OMA	HANVFFV.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_592-MONOMER.
Family and domain databases
HAMAP	MF_00109. Shikimate_kinase. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR000623. Shik_kinase. [Graphical view]
Pfam	PF01202. SKI. 1 hit. [Graphical view]
PRINTS	PR01100. SHIKIMTKNASE.
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS01128. SHIKIMATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROK_BLOPB

Accession

Primary (citable) accession number: Q492A4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	September 13, 2005
Last modified:	January 19, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)