Reviewed, UniProtKB/Swiss-Prot Q491Z2 (ILVC_BLOPB)

Names and origin

Protein names

Recommended name:
    Ketol-acid reductoisomerase
    EC=1.1.1.86
Alternative name(s):
    Acetohydroxy-acid isomeroreductase
    Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:	ilvC
Ordered Locus Names:	BPEN_609

Organism

Blochmannia pennsylvanicus (strain BPEN) [Complete proteome] [HAMAP]

Taxonomic identifier

291272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Ketol-acid reductoisomerase HAMAP MF_00435		PRO_1000190911
Sites
	Active site	132	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q491Z2-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 233D293C85CB3AD8	FASTA	491	55,237
	10 20 30 40 50 60 MANYFNTLTF IEKLKHLGKC RFMSNNEFSN GIQALLSKKV AIIGCGSQGL NQGLNMRDSG 70 80 90 100 110 120 VNITYALRRE SILNKQESWA RATRNGFPVG TYDEIIPKSD VVINLTPDKC HTSVIRQIEP 130 140 150 160 170 180 LMKHGSTLGY SHGFHIVEVG EKIRQDITVI MVAPKCPGTE VRQEYQRGFG VPALIAVHEE 190 200 210 220 230 240 NDTYDMGMTL AKSWAFALGS HRAGVLESSF VAEVKSDLMG EQTILCGMLQ AGSILCFDYM 250 260 270 280 290 300 ISNGVNAAYA GKFIQCGWEV ITEALKQGGI TLMMDRLSNA SKIRAFILSE KLKNILKPVF 310 320 330 340 350 360 EKHMENILNG VFSKEMMLDW ENNDSKLLKW REKTSQLPLE QAPNYQQEIL EQTYFDYGIL 370 380 390 400 410 420 MVAIIKSGIE LSFDTMIKSG IAPESAYYES LHELPLIANT IARKKLYEMN MVISDTAEYG 430 440 450 460 470 480 NYLFCDKVVP LLKKTIIPNL RTGDLGMSPK NVNVDNIVLR NTNDMIRNHT IEKVGIQLRS 490 YMQNMKSLSF N

References

[1]	"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects." Degnan P.H., Lazarus A.B., Wernegreen J.J. Genome Res. 15:1023-1033(2005) [PubMed: 16077009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000016 Genomic DNA. Translation: AAZ41210.1.
RefSeq	YP_278087.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q491Z2.
Genome annotation databases
GeneID	3563082.
GenomeReviews	Gene locus BPEN_609 in contig CP000016_GR.
KEGG	bpn:BPEN_609.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q491Z2.
OMA	LKHGGIT.
Enzyme and pathway databases
BioCyc	CBLO291272:BPEN_609-MON.
Family and domain databases
HAMAP	MF_00435. [Tree]
InterPro	IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013116. IlvN. IPR014359. KetolA_reductoisomerase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
PIRSF	PIRSF000116. IlvC_gammaproteo. 1 hit.
TIGRFAMs	TIGR00465. ilvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_BLOPB

Accession

Primary (citable) accession number: Q491Z2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)