ID   TPIS_BLOPB              Reviewed;         258 AA.
AC   Q491Y3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=Triosephosphate isomerase;
DE            Short=TIM;
DE            EC=5.3.1.1;
DE   AltName: Full=Triose-phosphate isomerase;
GN   Name=tpiA; OrderedLocusNames=BPEN_623;
OS   Blochmannia pennsylvanicus (strain BPEN).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; ant endosymbionts; Candidatus Blochmannia.
OX   NCBI_TaxID=291272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16077009; DOI=10.1101/gr.3771305;
RA   Degnan P.H., Lazarus A.B., Wernegreen J.J.;
RT   "Genome sequence of Blochmannia pennsylvanicus indicates parallel
RT   evolutionary trends among bacterial mutualists of insects.";
RL   Genome Res. 15:1023-1033(2005).
CC   -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate from glycerone phosphate: step 1/1.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
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DR   EMBL; CP000016; AAZ41221.1; -; Genomic_DNA.
DR   RefSeq; YP_278098.1; -.
DR   GeneID; 3563231; -.
DR   GenomeReviews; CP000016_GR; BPEN_623.
DR   KEGG; bpn:BPEN_623; -.
DR   HOGENOM; Q491Y3; -.
DR   OMA; Q491Y3; NFKMNGT.
DR   BioCyc; CBLO291272:BPEN_623-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:HAMAP.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:HAMAP.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:HAMAP.
DR   HAMAP; MF_00147; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000652; Triosephosphate_isomerase.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR21139; Triophos_ismrse; 1.
DR   Pfam; PF00121; TIM; 1.
DR   ProDom; PD001005; Triophos_ismrse; 1.
DR   TIGRFAMs; TIGR00419; tim; 1.
DR   PROSITE; PS00171; TIM_1; 1.
DR   PROSITE; PS51440; TIM_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase;
KW   Pentose shunt.
FT   CHAIN         1    258       Triosephosphate isomerase.
FT                                /FTId=PRO_0000307437.
FT   ACT_SITE     95     95       Electrophile (By similarity).
FT   ACT_SITE    167    167       Proton acceptor (By similarity).
FT   BINDING       9      9       Substrate (By similarity).
FT   BINDING      11     11       Substrate (By similarity).
SQ   SEQUENCE   258 AA;  28691 MW;  03B72435F9926A03 CRC64;
     MRRLLIIGNW KLNGNKNTIT NLIITLVNTF YNISKCNVAI APPVMYLDIT KRYLLNSRIQ
     LCAQNVDIHL SGSFTGDISA EMLQDLNVRY ALIGHSERRI HHKENDAYIA KKFFILKKVG
     LIPILCVGEN KREYDSGYTQ SVCINQINTI ITLLGIEAFK NSVIAYEPIW AIGSGASASP
     ENAQLVHKSI RDYIASYDTS IADKITIQYG GSVTPENVTK FFDQKDIDGV LVGAASLNAN
     SFSMIVQTAE NHKKSYPA
//