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Q49184

- DHP1_MYCFO

UniProt

Q49184 - DHP1_MYCFO

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Protein
Dihydropteroate synthase type-1
Gene
sulI, suf3
Organism
Mycobacterium fortuitum
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. The type II enzyme is stable whereas type I DHPS loses its activity rapidly By similarity. Implicated in resistance to sulfonamide.

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131Magnesium By similarity
Binding sitei21 – 211Substrate By similarity
Binding sitei86 – 861Substrate By similarity
Binding sitei105 – 1051Substrate By similarity
Binding sitei177 – 1771Substrate By similarity
Binding sitei216 – 2161Substrate By similarity
Binding sitei250 – 2501Substrate By similarity
Binding sitei252 – 2521Substrate By similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase type-1 (EC:2.5.1.15)
Alternative name(s):
Dihydropteroate pyrophosphorylase type I
Dihydropteroate synthase type I
Short name:
DHPS
Gene namesi
Name:sulI
Synonyms:suf3
OrganismiMycobacterium fortuitum
Taxonomic identifieri1766 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Dihydropteroate synthase type-1
PRO_0000321868Add
BLAST

Interactioni

Subunit structurei

Homodimer or homotrimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ49184.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 262257Pterin-binding
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Substrate binding By similarity

Sequence similaritiesi

Belongs to the DHPS family.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49184-1 [UniParc]FASTAAdd to Basket

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MLRSRVTVFG ILNLTEDSFF DESRRLDPAG AVTAAIEMLR VGSDVVDVGP    50
AASHPDARPV SPADEIRRIA PLLDALSDQM HRVSIDSFQP ETQRYALKRG 100
VGYLNDIQGF PDPALYPDIA EADCRLVVMH SAQRDGIATR TGHLRPEDAL 150
DEIVRFFEAR VSALRRSGVA ADRLILDPGM GFFLSPAPET SLHVLSNLQK 200
LKSALGLPLL VSVSRKSFLG ATVGLPVKDL GPASLAAELH AIGNGADYVR 250
THAPGDLRSA ITFSETLAKF RSRDARDRGL DHA 283
Length:283
Mass (Da):30,639
Last modified:November 1, 1996 - v1
Checksum:iF04DB17FB1A4951E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53635 Genomic DNA. Translation: CAA37684.1.
PIRiS10928.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53635 Genomic DNA. Translation: CAA37684.1 .
PIRi S10928.

3D structure databases

ProteinModelPortali Q49184.
ModBasei Search...
MobiDBi Search...

Chemistry

DrugBanki DB00891. Sulfapyridine.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00156 .

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Transposition of an antibiotic resistance element in mycobacteria."
    Martin C., Timm J., Rauzier J., Gomez-Lus R., Davies J., Gicquel B.
    Nature 345:739-743(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INVOLVEMENT IN RESISTANCE TO SULFONAMIDE.
    Strain: FC1.
    Transposon: Tn610.

Entry informationi

Entry nameiDHP1_MYCFO
AccessioniPrimary (citable) accession number: Q49184
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The sulI gene is located on various large self-transmissible resistance plasmids and on transposons related to Tn21.

Keywords - Technical termi

Transposable element

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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