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Q49184

- DHP1_MYCFO

UniProt

Q49184 - DHP1_MYCFO

Protein

Dihydropteroate synthase type-1

Gene

sulI

Organism
Mycobacterium fortuitum
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    DHPS catalyzes the formation of the immediate precursor of folic acid. The type II enzyme is stable whereas type I DHPS loses its activity rapidly By similarity. Implicated in resistance to sulfonamide.By similarity

    Catalytic activityi

    (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

    Cofactori

    Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi13 – 131MagnesiumBy similarity
    Binding sitei21 – 211SubstrateBy similarity
    Binding sitei86 – 861SubstrateBy similarity
    Binding sitei105 – 1051SubstrateBy similarity
    Binding sitei177 – 1771SubstrateBy similarity
    Binding sitei216 – 2161SubstrateBy similarity
    Binding sitei250 – 2501SubstrateBy similarity
    Binding sitei252 – 2521SubstrateBy similarity

    GO - Molecular functioni

    1. dihydropteroate synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. folic acid biosynthetic process Source: UniProtKB-KW
    2. response to antibiotic Source: UniProtKB-KW
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Antibiotic resistance, Folate biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00077; UER00156.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydropteroate synthase type-1 (EC:2.5.1.15)
    Alternative name(s):
    Dihydropteroate pyrophosphorylase type I
    Dihydropteroate synthase type I
    Short name:
    DHPS
    Gene namesi
    Name:sulI
    Synonyms:suf3
    OrganismiMycobacterium fortuitum
    Taxonomic identifieri1766 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Dihydropteroate synthase type-1PRO_0000321868Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer or homotrimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ49184.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 262257Pterin-bindingPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni53 – 542Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the DHPS family.Curated
    Contains 1 pterin-binding domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.20.20.20. 1 hit.
    InterProiIPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000489. Pterin-binding.
    [Graphical view]
    PfamiPF00809. Pterin_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF51717. SSF51717. 1 hit.
    TIGRFAMsiTIGR01496. DHPS. 1 hit.
    PROSITEiPS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q49184-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRSRVTVFG ILNLTEDSFF DESRRLDPAG AVTAAIEMLR VGSDVVDVGP    50
    AASHPDARPV SPADEIRRIA PLLDALSDQM HRVSIDSFQP ETQRYALKRG 100
    VGYLNDIQGF PDPALYPDIA EADCRLVVMH SAQRDGIATR TGHLRPEDAL 150
    DEIVRFFEAR VSALRRSGVA ADRLILDPGM GFFLSPAPET SLHVLSNLQK 200
    LKSALGLPLL VSVSRKSFLG ATVGLPVKDL GPASLAAELH AIGNGADYVR 250
    THAPGDLRSA ITFSETLAKF RSRDARDRGL DHA 283
    Length:283
    Mass (Da):30,639
    Last modified:November 1, 1996 - v1
    Checksum:iF04DB17FB1A4951E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53635 Genomic DNA. Translation: CAA37684.1.
    PIRiS10928.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53635 Genomic DNA. Translation: CAA37684.1 .
    PIRi S10928.

    3D structure databases

    ProteinModelPortali Q49184.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    DrugBanki DB00891. Sulfapyridine.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00156 .

    Family and domain databases

    Gene3Di 3.20.20.20. 1 hit.
    InterProi IPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000489. Pterin-binding.
    [Graphical view ]
    Pfami PF00809. Pterin_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51717. SSF51717. 1 hit.
    TIGRFAMsi TIGR01496. DHPS. 1 hit.
    PROSITEi PS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transposition of an antibiotic resistance element in mycobacteria."
      Martin C., Timm J., Rauzier J., Gomez-Lus R., Davies J., Gicquel B.
      Nature 345:739-743(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INVOLVEMENT IN RESISTANCE TO SULFONAMIDE.
      Strain: FC1.
      Transposon: Tn610.

    Entry informationi

    Entry nameiDHP1_MYCFO
    AccessioniPrimary (citable) accession number: Q49184
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The sulI gene is located on various large self-transmissible resistance plasmids and on transposons related to Tn21.

    Keywords - Technical termi

    Transposable element

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3