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Protein

Polyferredoxin protein MvhB

Gene

mvhB

Organism
Methanothermus fervidus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 10 [4Fe-4S] clusters.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi12Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi15Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi19Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi75Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi78Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi81Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi85Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi107Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi110Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi113Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi117Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi146Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi149Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi152Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi156Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi177Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi180Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi183Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi187Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi216Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi219Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi222Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi226Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi245Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi248Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi251Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi255Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi284Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi287Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi290Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi294Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi324Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi327Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi330Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi334Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi365Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi368Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi371Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi375Iron-sulfur (4Fe-4S)Sequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyferredoxin protein MvhB
Gene namesi
Name:mvhB
OrganismiMethanothermus fervidus
Taxonomic identifieri2180 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001591421 – 412Polyferredoxin protein MvhBAdd BLAST412

Interactioni

Protein-protein interaction databases

STRINGi523846.Mfer_0730.

Structurei

3D structure databases

ProteinModelPortaliQ49180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 294Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST28
Domaini30 – 574Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST28
Domaini66 – 954Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd BLAST30
Domaini96 – 1274Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd BLAST32
Domaini138 – 1664Fe-4S ferredoxin-type 5PROSITE-ProRule annotationAdd BLAST29
Domaini168 – 1974Fe-4S ferredoxin-type 6PROSITE-ProRule annotationAdd BLAST30
Domaini207 – 2364Fe-4S ferredoxin-type 7PROSITE-ProRule annotationAdd BLAST30
Domaini237 – 2654Fe-4S ferredoxin-type 8PROSITE-ProRule annotationAdd BLAST29
Domaini275 – 3044Fe-4S ferredoxin-type 9PROSITE-ProRule annotationAdd BLAST30
Domaini311 – 3444Fe-4S ferredoxin-type 10PROSITE-ProRule annotationAdd BLAST34
Domaini356 – 3854Fe-4S ferredoxin-type 11PROSITE-ProRule annotationAdd BLAST30
Domaini386 – 4124Fe-4S ferredoxin-type 12PROSITE-ProRule annotationAdd BLAST27

Sequence similaritiesi

Contains 12 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG02181. Archaea.
COG1145. LUCA.

Family and domain databases

InterProiIPR001080. 3Fe4S_ferredoxin.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
PF12838. Fer4_7. 3 hits.
PF13187. Fer4_9. 1 hit.
[Graphical view]
PRINTSiPR00352. 3FE4SFRDOXIN.
PROSITEiPS00198. 4FE4S_FER_1. 10 hits.
PS51379. 4FE4S_FER_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVINKEDCI RCGACQGVCP TGAISVKPED VIYCDMCGGE PKCVEACPND
60 70 80 90 100
ALRHEDITLE GGIKKKKITY SPEKCDKCGE CVKVCPPGIL KLVNDGKASR
110 120 130 140 150
VPLEGFCVLC QQCVNVCPIE VIGIEGVKEP ARVEIKIDKP IYIVDCVGCG
160 170 180 190 200
LCVPECPVNA ITLPKYGESI EIDEEKCIKC GICAQTCPWN SVYISGKKPQ
210 220 230 240 250
KSSRTIENFT LDKEECIGCN TCVEICPGGF IEPKSDLTVS LPEICPACGL
260 270 280 290 300
CEKLCPTDAI ELEVKLGPAK PVTEEGIVYN DENCKFCGRC ALNCPNEAIR
310 320 330 340 350
VVSPKGRVFP GLKKVDEKES YTICTTCGAC TTVCPTGALK LVEVSKKVNG
360 370 380 390 400
ETVKRNRIQY NPSLCDKCGN CVDVCPYGIL KLTDDEKLPV KGFCILCEKC
410
IDACRFNALL IK
Length:412
Mass (Da):44,642
Last modified:November 1, 1996 - v1
Checksum:i886F2F9CA9EDFCF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34016 Genomic DNA. Translation: AAA72833.1.
PIRiC37777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34016 Genomic DNA. Translation: AAA72833.1.
PIRiC37777.

3D structure databases

ProteinModelPortaliQ49180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi523846.Mfer_0730.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiarCOG02181. Archaea.
COG1145. LUCA.

Family and domain databases

InterProiIPR001080. 3Fe4S_ferredoxin.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
PF12838. Fer4_7. 3 hits.
PF13187. Fer4_9. 1 hit.
[Graphical view]
PRINTSiPR00352. 3FE4SFRDOXIN.
PROSITEiPS00198. 4FE4S_FER_1. 10 hits.
PS51379. 4FE4S_FER_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMVHB_METFE
AccessioniPrimary (citable) accession number: Q49180
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.