Q49179 (MVHA_METFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
F420-non-reducing hydrogenase subunit A
EC=1.12.99.-

Alternative name(s):
Methyl viologen-reducing hydrogenase subunit alpha
Short name=MVH subunit A

Gene names

Name:

mvhA

Organism

Methanothermus fervidus

Taxonomic identifier

2180 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanothermaceae › Methanothermus

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of a complex that provides reducing equivalents for heterodisulfide reductase By similarity.
Cofactor	Nickel Potential.
Subunit structure	The F420-non-reducing hydrogenase is composed of three subunits; mvhA, mvhD and mvhG. It forms a complex with the heterodisulfide reductase (hdr) By similarity.
Sequence similarities	Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

Ontologies

Keywords
Ligand	Metal-binding Nickel
Molecular function	Oxidoreductase
Gene Ontology (GO)
Molecular function	ferredoxin hydrogenase activity Inferred from electronic annotation. Source: InterPro nickel cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 472	472	F420-non-reducing hydrogenase subunit A		PRO_0000199725
Sites
	Metal binding	61	1	Nickel Potential
	Metal binding	64	1	Nickel Potential
	Metal binding	442	1	Nickel Potential
	Metal binding	445	1	Nickel Potential

Sequences

	Sequence		Length	Mass (Da)
	Q49179 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4E8886BEDEBE3947	FASTA	472	53,311
	10 20 30 40 50 60 MEKLVLEPVT RIEGHAKITV QLDEEGNVKD TRFHVMEFRG FEKFLQGRRI EEAPRIVPRI 70 80 90 100 110 120 CGICQVQHHL ASAKAVDACF GFEPEDIPET AYKMREIMNW ASYVHSHGLH FYFLAAPDFI 130 140 150 160 170 180 GGKDRETRNI FKIIQDSPDV AKQAIELRKN AQDIVAATGG RAIHPVSFIP GGITTELDKE 190 200 210 220 230 240 TQEKLLKKAK RNVEIAESTL ELAIPIFEDN MDLVESLGTI ETYHMGLVKN GTWDVYDGVV 250 260 270 280 290 300 RVKDKNGENF AEFGPDEYTK YIAEHVKPYS WLKFPYLKEL GYPDGVYRVS PLSRLNVADK 310 320 330 340 350 360 MPDAAPKAQE YFKEFRNKFG YAQQPLLYHW ARLIEMLAAA ECMASVLEED LSGKKIHGKL 370 380 390 400 410 420 ERQEGEGVGI VEAPRGTLIH HYACDKNGII TKANLIVATV QNNPAMEMGI QKVAKERIKP 430 440 450 460 470 GVDVDDKIYN LMEMVIRAYD PCLSCATHTV DGKVKLFTLE VLDSEGNVVK RL

References

[1]	"Conservation of hydrogenase and polyferredoxin structures in the hyperthermophilic archaebacterium Methanothermus fervidus." Steigerwald V.J., Beckler G.S., Reeve J.N. J. Bacteriol. 172:4715-4718(1990) [PubMed: 2115877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M34016 Genomic DNA. Translation: AAA72832.1.
PIR	B37777.
3D structure databases
ProteinModelPortal	Q49179.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001501. Ni-dep_hyd_lsu. IPR018194. Ni-dep_hyd_lsu_Ni_BS. [Graphical view]
Pfam	PF00374. NiFeSe_Hases. 2 hits. [Graphical view]
PROSITE	PS00507. NI_HGENASE_L_1. 1 hit. PS00508. NI_HGENASE_L_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MVHA_METFE

Accession

Primary (citable) accession number: Q49179

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	November 1, 1996
Last modified:	September 21, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program