ID   MTRE_METFE              Reviewed;         257 AA.
AC   Q49176;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   16-JUN-2009, entry version 44.
DE   RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit E;
DE            EC=2.1.1.86;
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E;
GN   Name=mtrE;
OS   Methanothermus fervidus.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanothermaceae; Methanothermus.
OX   NCBI_TaxID=2180;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=89008091; PubMed=3170483;
RA   Weil C.F., Cram D.S., Sherf B.A., Reeve J.N.;
RT   "Structure and comparative analysis of the genes encoding component C
RT   of methyl coenzyme M reductase in the extremely thermophilic
RT   archaebacterium Methanothermus fervidus.";
RL   J. Bacteriol. 170:4718-4726(1988).
CC   -!- FUNCTION: Part of a complex that catalyzes the formation of
CC       methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and
CC       methyl-tetrahydromethanopterin. This is an energy-conserving,
CC       sodium-ion translocating step (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-
CC       mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-
CC       (methylthio)ethanesulfonate.
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from carbone
CC       dioxide; methyl-CoM from 5,10-methylene-H(4)MPT: step 2/2.
CC   -!- SUBUNIT: The complex is composed of 8 subunits; mtrA, mtrB, mtrC,
CC       mtrD, mtrE, mtrF, mtrG and mtrH (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the mtrE family.
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DR   EMBL; J03375; AAA72198.1; -; Genomic_DNA.
DR   BRENDA; 2.1.1.86; 7358.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0012506; C:vesicle membrane; IEA:InterPro.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase...; IEA:HAMAP.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   HAMAP; MF_01098; -; 1.
DR   InterPro; IPR005780; MeTrfase_E.
DR   Pfam; PF04206; MtrE; 1.
DR   PIRSF; PIRSF016509; MtrE; 1.
DR   TIGRFAMs; TIGR01113; mtrE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Methanogenesis; Methyltransferase;
KW   One-carbon metabolism; Transferase; Transmembrane.
FT   CHAIN         1    257       Tetrahydromethanopterin S-
FT                                methyltransferase subunit E.
FT                                /FTId=PRO_0000147538.
FT   TRANSMEM      4     24       Potential.
FT   TRANSMEM     62     82       Potential.
FT   TRANSMEM     84    104       Potential.
FT   TRANSMEM    132    152       Potential.
FT   TRANSMEM    164    184       Potential.
FT   TRANSMEM    229    249       Potential.
SQ   SEQUENCE   257 AA;  26896 MW;  389DEF5E7BE36B15 CRC64;
     MDPAVASLGI LALTTASAII GQTIEDVETN IGSQSNPNSQ VQLAPQMGNL HRFFNKAIAG
     EPFAYCTFCG VSGAITVATL YLHLPAVIAL AIGAAITTLI WLAYSTTAYL GRVSGSATFN
     QPVFLDMLTE NLGPIAGHAF IVFFCMTGVA YLMTLPVKGF AHPFPIPVIG MIWGMTIGAI
     GSAVGDVYYG AEAEFVHKKF GGGIPVASHG DITRKGVLGA RSPMEVGNFT VKYGSPITGM
     AFGLIVLSIT RGVYNIE
//