Q49176 (MTRE_METFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetrahydromethanopterin S-methyltransferase subunit E
EC=2.1.1.86

Alternative name(s):
N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E

Gene names

Name:

mtrE

Organism

Methanothermus fervidus

Taxonomic identifier

2180 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanothermaceae › Methanothermus

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step By similarity. HAMAP MF_01098
Catalytic activity	5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate. HAMAP MF_01098
Pathway	One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2. HAMAP MF_01098
Subunit structure	The complex is composed of 8 subunits; mtrA, mtrB, mtrC, mtrD, mtrE, mtrF, mtrG and mtrH By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential HAMAP MF_01098.
Sequence similarities	Belongs to the mtrE family.

Ontologies

Keywords
Biological process	Methanogenesis One-carbon metabolism
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell vesicle membrane Inferred from electronic annotation. Source: InterPro
Molecular function	tetrahydromethanopterin S-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Tetrahydromethanopterin S-methyltransferase subunit E HAMAP MF_01098		PRO_0000147538
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	132 – 152	21	Helical; Potential
	Transmembrane	164 – 184	21	Helical; Potential
	Transmembrane	229 – 249	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q49176 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 389DEF5E7BE36B15	FASTA	257	26,896
	10 20 30 40 50 60 MDPAVASLGI LALTTASAII GQTIEDVETN IGSQSNPNSQ VQLAPQMGNL HRFFNKAIAG 70 80 90 100 110 120 EPFAYCTFCG VSGAITVATL YLHLPAVIAL AIGAAITTLI WLAYSTTAYL GRVSGSATFN 130 140 150 160 170 180 QPVFLDMLTE NLGPIAGHAF IVFFCMTGVA YLMTLPVKGF AHPFPIPVIG MIWGMTIGAI 190 200 210 220 230 240 GSAVGDVYYG AEAEFVHKKF GGGIPVASHG DITRKGVLGA RSPMEVGNFT VKYGSPITGM 250 AFGLIVLSIT RGVYNIE

References

[1]

"Structure and comparative analysis of the genes encoding component C of methyl coenzyme M reductase in the extremely thermophilic archaebacterium Methanothermus fervidus." Weil C.F., Cram D.S., Sherf B.A., Reeve J.N. J. Bacteriol. 170:4718-4726(1988) [PubMed: 3170483] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	J03375 Genomic DNA. Translation: AAA72198.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01098. MtrE. [Tree]
InterPro	IPR005780. MeTrfase_E. [Graphical view]
Pfam	PF04206. MtrE. 1 hit. [Graphical view]
PIRSF	PIRSF016509. MtrE. 1 hit.
TIGRFAMs	TIGR01113. MtrE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MTRE_METFE

Accession

Primary (citable) accession number: Q49176

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 31, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program