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Q49174

- MCRX_METFV

UniProt

Q49174 - MCRX_METFV

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Protein
Methyl-coenzyme M reductase II subunit alpha
Gene
mrtA, mcrIIA, Mfer_0734
Organism
Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide By similarity.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Cofactori

Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme F430 is a yellow nickel porphinoid By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi151 – 1511Nickel By similarity

GO - Molecular functioni

  1. coenzyme-B sulfoethylthiotransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. methanogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Methanogenesis

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

BioCyciMFER523846:GC24-763-MONOMER.
UniPathwayiUPA00646; UER00699.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase II subunit alpha (EC:2.8.4.1)
Short name:
MCR II alpha
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase alpha
Gene namesi
Name:mrtA
Synonyms:mcrIIA
Ordered Locus Names:Mfer_0734
OrganismiMethanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Taxonomic identifieri523846 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus
ProteomesiUP000002315: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Methyl-coenzyme M reductase II subunit alpha
PRO_0000147451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei261 – 2611Pros-methylhistidine By similarity
Modified residuei275 – 27515-methylarginine By similarity

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains By similarity.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000225809.
KOiK00399.
OMAiGHQPEYA.

Family and domain databases

Gene3Di1.20.840.10. 1 hit.
3.30.70.470. 1 hit.
3.90.390.10. 1 hit.
InterProiIPR022681. MCR_a/b_chain_a-bundle.
IPR016212. Me_CoM_Rdtase_asu.
IPR008924. Me_CoM_Rdtase_asu/bsu_C.
IPR009047. Me_CoM_Rdtase_asu_C.
IPR003183. Me_CoM_Rdtase_asu_N.
IPR015811. Me_CoM_Rdtase_asu_N_sub1.
IPR015823. Me_CoM_Rdtase_asu_N_sub2.
IPR009024. Me_CoM_Rdtase_Fd-like_fold.
[Graphical view]
PfamiPF02249. MCR_alpha. 1 hit.
PF02745. MCR_alpha_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000262. MCR_alpha. 1 hit.
SUPFAMiSSF48081. SSF48081. 1 hit.
SSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03256. met_CoM_red_alp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49174-1 [UniParc]FASTAAdd to Basket

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MNKKNKKLFL EALEKKFKGE SPEEKKTTFY CFGGWKQSER KREFVEYAKK    50
LAKKRGIPFY NPDIGVPLGQ RKLMAYRISG TDAYVEGDDL HFVNNAAIQQ 100
MVDDIKRTVI VGMDTAHAVL EKRLGVEVTP ETINEYMETI NHALPGGAVV 150
QEHMVEVHPG LVDDCYAKIF TGNDELADEL DKRVLIDINK EFPEEQAEML 200
KKYIGNRTYQ VNRVPTIVVR CCDGGTVSRW SAMQIGMSFI SAYKLCAGEA 250
AIADFSFAAK HADVIEMGTI LPARRARGPN EPGGIPFGVF ADIIQTSRVS 300
DDPARISLEV IGAAATLYDQ VWLGSYMSGG VGFTQYASAT YTDDILDDFV 350
YYGAEYVEDK YGFCGVKPSM EVVKDIATEV TLYGLEQYEE YPTLLEDHFG 400
GSQRAAVVAA AAGCSTAFAT GNSNAGINAW YLSQILHKEG HSRLGFYGYD 450
LQDQCGASNS LSIRSDEGLV HELRGPNYPN YAMNVGHQPE YAGIAQAPHA 500
ARGDAFVVNP LIKVAFADND LSFDFRWPRK EIARGALREF MPDGERTLII 550
PASK 554
Length:554
Mass (Da):61,326
Last modified:March 8, 2011 - v2
Checksum:iE894701807E22919
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti273 – 2731A → G in CAA50044. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70765 Genomic DNA. Translation: CAA50044.1.
CP002278 Genomic DNA. Translation: ADP77533.1.
PIRiS43897.
RefSeqiWP_013413811.1. NC_014658.1.
YP_004004295.1. NC_014658.1.

Genome annotation databases

EnsemblBacteriaiADP77533; ADP77533; Mfer_0734.
GeneIDi9962464.
KEGGimfv:Mfer_0734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70765 Genomic DNA. Translation: CAA50044.1 .
CP002278 Genomic DNA. Translation: ADP77533.1 .
PIRi S43897.
RefSeqi WP_013413811.1. NC_014658.1.
YP_004004295.1. NC_014658.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADP77533 ; ADP77533 ; Mfer_0734 .
GeneIDi 9962464.
KEGGi mfv:Mfer_0734.

Phylogenomic databases

HOGENOMi HOG000225809.
KOi K00399.
OMAi GHQPEYA.

Enzyme and pathway databases

UniPathwayi UPA00646 ; UER00699 .
BioCyci MFER523846:GC24-763-MONOMER.

Family and domain databases

Gene3Di 1.20.840.10. 1 hit.
3.30.70.470. 1 hit.
3.90.390.10. 1 hit.
InterProi IPR022681. MCR_a/b_chain_a-bundle.
IPR016212. Me_CoM_Rdtase_asu.
IPR008924. Me_CoM_Rdtase_asu/bsu_C.
IPR009047. Me_CoM_Rdtase_asu_C.
IPR003183. Me_CoM_Rdtase_asu_N.
IPR015811. Me_CoM_Rdtase_asu_N_sub1.
IPR015823. Me_CoM_Rdtase_asu_N_sub2.
IPR009024. Me_CoM_Rdtase_Fd-like_fold.
[Graphical view ]
Pfami PF02249. MCR_alpha. 1 hit.
PF02745. MCR_alpha_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000262. MCR_alpha. 1 hit.
SUPFAMi SSF48081. SSF48081. 1 hit.
SSF55088. SSF55088. 1 hit.
TIGRFAMsi TIGR03256. met_CoM_red_alp. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and phylogeny of mcrII, a gene cluster encoding an isoenzyme of methyl coenzyme M reductase from hyperthermophilic Methanothermus fervidus."
    Lehmacher A., Klenk H.-P.
    Mol. Gen. Genet. 243:198-206(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43054 / DSM 2088 / JCM 10308 / V24 S.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43054 / DSM 2088 / JCM 10308 / V24 S.

Entry informationi

Entry nameiMCRX_METFV
AccessioniPrimary (citable) accession number: Q49174
Secondary accession number(s): E3GZ01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 8, 2011
Last modified: September 3, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

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