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Protein

Methyl-coenzyme M reductase II subunit alpha

Gene

mrtA

Organism
Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.By similarity

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Cofactori

coenzyme F430By similarityNote: Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme F430 is a yellow nickel porphinoid.By similarity

Pathwayi: methyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase subunit gamma (Mfer_0785), Methyl-coenzyme M reductase subunit alpha (Mfer_0784), Methyl-coenzyme M reductase II subunit alpha (mrtA), Methyl-coenzyme M reductase II subunit gamma (mrtG), Methyl-coenzyme M reductase II subunit beta (mrtB), Methyl-coenzyme M reductase subunit beta (Mfer_0788)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi151NickelBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMethanogenesis
LigandMetal-binding, Nickel

Enzyme and pathway databases

BioCyciMFER523846:G1GOR-758-MONOMER
UniPathwayiUPA00646; UER00699

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase II subunit alpha (EC:2.8.4.1)
Short name:
MCR II alpha
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase alpha
Gene namesi
Name:mrtA
Synonyms:mcrIIA
Ordered Locus Names:Mfer_0734
OrganismiMethanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Taxonomic identifieri523846 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus
Proteomesi
  • UP000002315 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001474511 – 554Methyl-coenzyme M reductase II subunit alphaAdd BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei261Pros-methylhistidineBy similarity1
Modified residuei2755-methylarginineBy similarity1

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.By similarity

Protein-protein interaction databases

STRINGi523846.Mfer_0734

Structurei

3D structure databases

SMRiQ49174
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiarCOG04857 Archaea
COG4058 LUCA
HOGENOMiHOG000225809
KOiK00399
OMAiVGHQPEY
OrthoDBiPOG093Z00ZI

Family and domain databases

Gene3Di1.20.840.10, 1 hit
3.30.70.470, 1 hit
3.90.390.10, 1 hit
InterProiView protein in InterPro
IPR016212 Me_CoM_Rdtase_asu
IPR008924 Me_CoM_Rdtase_asu/bsu_C
IPR009047 Me_CoM_Rdtase_asu_C
IPR003183 Me_CoM_Rdtase_asu_N
IPR015811 Me_CoM_Rdtase_asu_N_sub1
IPR015823 Me_CoM_Rdtase_asu_N_sub2
IPR009024 Me_CoM_Rdtase_Fd-like_fold
PfamiView protein in Pfam
PF02249 MCR_alpha, 1 hit
PF02745 MCR_alpha_N, 1 hit
PIRSFiPIRSF000262 MCR_alpha, 1 hit
SUPFAMiSSF48081 SSF48081, 1 hit
SSF55088 SSF55088, 1 hit
TIGRFAMsiTIGR03256 met_CoM_red_alp, 1 hit

Sequencei

Sequence statusi: Complete.

Q49174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKNKKLFL EALEKKFKGE SPEEKKTTFY CFGGWKQSER KREFVEYAKK
60 70 80 90 100
LAKKRGIPFY NPDIGVPLGQ RKLMAYRISG TDAYVEGDDL HFVNNAAIQQ
110 120 130 140 150
MVDDIKRTVI VGMDTAHAVL EKRLGVEVTP ETINEYMETI NHALPGGAVV
160 170 180 190 200
QEHMVEVHPG LVDDCYAKIF TGNDELADEL DKRVLIDINK EFPEEQAEML
210 220 230 240 250
KKYIGNRTYQ VNRVPTIVVR CCDGGTVSRW SAMQIGMSFI SAYKLCAGEA
260 270 280 290 300
AIADFSFAAK HADVIEMGTI LPARRARGPN EPGGIPFGVF ADIIQTSRVS
310 320 330 340 350
DDPARISLEV IGAAATLYDQ VWLGSYMSGG VGFTQYASAT YTDDILDDFV
360 370 380 390 400
YYGAEYVEDK YGFCGVKPSM EVVKDIATEV TLYGLEQYEE YPTLLEDHFG
410 420 430 440 450
GSQRAAVVAA AAGCSTAFAT GNSNAGINAW YLSQILHKEG HSRLGFYGYD
460 470 480 490 500
LQDQCGASNS LSIRSDEGLV HELRGPNYPN YAMNVGHQPE YAGIAQAPHA
510 520 530 540 550
ARGDAFVVNP LIKVAFADND LSFDFRWPRK EIARGALREF MPDGERTLII

PASK
Length:554
Mass (Da):61,326
Last modified:March 8, 2011 - v2
Checksum:iE894701807E22919
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti273A → G in CAA50044 (PubMed:8177216).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70765 Genomic DNA Translation: CAA50044.1
CP002278 Genomic DNA Translation: ADP77533.1
PIRiS43897
RefSeqiWP_013413811.1, NC_014658.1

Genome annotation databases

EnsemblBacteriaiADP77533; ADP77533; Mfer_0734
GeneIDi9962464
KEGGimfv:Mfer_0734

Similar proteinsi

Entry informationi

Entry nameiMCRX_METFV
AccessioniPrimary (citable) accession number: Q49174
Secondary accession number(s): E3GZ01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 8, 2011
Last modified: March 28, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health