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Q49173

- MCRZ_METFV

UniProt

Q49173 - MCRZ_METFV

Protein

Methyl-coenzyme M reductase II subunit gamma

Gene

mrtG

Organism
Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

    Catalytic activityi

    Methyl-CoM + CoB = CoM-S-S-CoB + methane.

    Pathwayi

    GO - Molecular functioni

    1. coenzyme-B sulfoethylthiotransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. methanogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Methanogenesis

    Enzyme and pathway databases

    BioCyciMFER523846:GC24-762-MONOMER.
    UniPathwayiUPA00646; UER00699.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyl-coenzyme M reductase II subunit gamma (EC:2.8.4.1)
    Short name:
    MCR II gamma
    Alternative name(s):
    Coenzyme-B sulfoethylthiotransferase gamma
    Gene namesi
    Name:mrtG
    Synonyms:mcrIIG
    Ordered Locus Names:Mfer_0733
    OrganismiMethanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
    Taxonomic identifieri523846 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus
    ProteomesiUP000002315: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Methyl-coenzyme M reductase II subunit gammaPRO_0000147475Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer of two alpha, two beta, and two gamma chains.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ49173.
    SMRiQ49173. Positions 6-251.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000225820.
    KOiK00402.
    OMAiGHRNPGE.

    Family and domain databases

    Gene3Di3.90.320.20. 1 hit.
    InterProiIPR009024. Me_CoM_Rdtase_Fd-like_fold.
    IPR003178. Me_CoM_Rdtase_gsu.
    [Graphical view]
    PfamiPF02240. MCR_gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000264. Meth_CoM_rd_gama. 1 hit.
    ProDomiPD005845. Me_CoM_Rdtase_gsu. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF55088. SSF55088. 1 hit.
    TIGRFAMsiTIGR03259. met_CoM_red_gam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q49173-1 [UniParc]FASTAAdd to Basket

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    MAYEPQFNPG ETKIAENRRK HMNPNYELKK LREIADEDIV RVLGHRSPGE    50
    SFKTVHPPLE EMDFEEDPMK DIVEPIEGAK QGTRIRYIQF ADSMYNAPAQ 100
    PYDRARTYMW RFRGVDTGTL SGRQVIEMRE LDLEKVSKIL LETEIFDPAR 150
    CGIRGATVHG HSLRFDENGL MFDALQRYIY DEDSGHVVYV KDQVGRPLDQ 200
    PVDMGEPLPE DELKEITTIY RKDNIGMRED EELLEVVNKI HEARTIGGFG 250
    MEVFKKDLNK RLGGANE 267
    Length:267
    Mass (Da):30,847
    Last modified:November 1, 1996 - v1
    Checksum:i150D5FFAE6BC6F9D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70765 Genomic DNA. Translation: CAA50043.1.
    CP002278 Genomic DNA. Translation: ADP77532.1.
    PIRiS43900.
    RefSeqiWP_013413810.1. NC_014658.1.
    YP_004004294.1. NC_014658.1.

    Genome annotation databases

    EnsemblBacteriaiADP77532; ADP77532; Mfer_0733.
    GeneIDi9962463.
    KEGGimfv:Mfer_0733.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70765 Genomic DNA. Translation: CAA50043.1 .
    CP002278 Genomic DNA. Translation: ADP77532.1 .
    PIRi S43900.
    RefSeqi WP_013413810.1. NC_014658.1.
    YP_004004294.1. NC_014658.1.

    3D structure databases

    ProteinModelPortali Q49173.
    SMRi Q49173. Positions 6-251.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADP77532 ; ADP77532 ; Mfer_0733 .
    GeneIDi 9962463.
    KEGGi mfv:Mfer_0733.

    Phylogenomic databases

    HOGENOMi HOG000225820.
    KOi K00402.
    OMAi GHRNPGE.

    Enzyme and pathway databases

    UniPathwayi UPA00646 ; UER00699 .
    BioCyci MFER523846:GC24-762-MONOMER.

    Family and domain databases

    Gene3Di 3.90.320.20. 1 hit.
    InterProi IPR009024. Me_CoM_Rdtase_Fd-like_fold.
    IPR003178. Me_CoM_Rdtase_gsu.
    [Graphical view ]
    Pfami PF02240. MCR_gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000264. Meth_CoM_rd_gama. 1 hit.
    ProDomi PD005845. Me_CoM_Rdtase_gsu. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF55088. SSF55088. 1 hit.
    TIGRFAMsi TIGR03259. met_CoM_red_gam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and phylogeny of mcrII, a gene cluster encoding an isoenzyme of methyl coenzyme M reductase from hyperthermophilic Methanothermus fervidus."
      Lehmacher A., Klenk H.-P.
      Mol. Gen. Genet. 243:198-206(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 43054 / DSM 2088 / JCM 10308 / V24 S.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43054 / DSM 2088 / JCM 10308 / V24 S.

    Entry informationi

    Entry nameiMCRZ_METFV
    AccessioniPrimary (citable) accession number: Q49173
    Secondary accession number(s): E3GZ00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3