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Reviewed, UniProtKB/Swiss-Prot Q49173 (MCRZ_METFE)

Last modified September 22, 2009. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Methyl-coenzyme M reductase II subunit gamma
      Short name=MCR II gamma
    EC=2.8.4.1
Alternative name(s):
    Coenzyme-B sulfoethylthiotransferase gamma
Gene names
Name: mrtG
Synonyms: mcrIIG
OrganismMethanothermus fervidus
Taxonomic identifier2180 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and an heterodisulfide.

Catalytic activity

2-(methylthio)ethanesulfonate (methyl-CoM) + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate (coenzyme B) = CoM-S-S-CoB + methane.

Cofactor

Binds 2 coenzyme F430 noncovalently per hexamer. Coenzyme F430 is a yellow nickel porphinoid By similarity.

Pathway

One-carbon metabolism; methyl-coenzyme M reduction; methane from methyl-coenzyme M: step 1/1.

Subunit structure

Hexamer of two alpha, two beta, and two gamma chains By similarity.

Ontologies

Keywords
   Biological processMethanogenesis
   Molecular functionTransferase
Gene Ontology (GO)
   Biological processmethanogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncoenzyme-B sulfoethylthiotransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Methyl-coenzyme M reductase II subunit gamma
PRO_0000147475

Sequences

Sequence LengthMass (Da)Tools
Q49173-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 150D5FFAE6BC6F9D

FASTA26730,847
        10         20         30         40         50         60 
MAYEPQFNPG ETKIAENRRK HMNPNYELKK LREIADEDIV RVLGHRSPGE SFKTVHPPLE 

        70         80         90        100        110        120 
EMDFEEDPMK DIVEPIEGAK QGTRIRYIQF ADSMYNAPAQ PYDRARTYMW RFRGVDTGTL 

       130        140        150        160        170        180 
SGRQVIEMRE LDLEKVSKIL LETEIFDPAR CGIRGATVHG HSLRFDENGL MFDALQRYIY 

       190        200        210        220        230        240 
DEDSGHVVYV KDQVGRPLDQ PVDMGEPLPE DELKEITTIY RKDNIGMRED EELLEVVNKI 

       250        260 
HEARTIGGFG MEVFKKDLNK RLGGANE 

« Hide

References

[1]"Characterization and phylogeny of mcrII, a gene cluster encoding an isoenzyme of methyl coenzyme M reductase from hyperthermophilic Methanothermus fervidus."
Lehmacher A., Klenk H.-P.
Mol. Gen. Genet. 243:198-206(1994) [PubMed: 8177216] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 2088 / V24S.

Cross-references

Sequence databases

X70765 Genomic DNA. Translation: CAA50043.1.
PIRS43900.

3D structure databases

HSSPHSSP built from PDB template 1E6V based on UniProtKB Q49604.
ModBaseSearch...

Enzyme and pathway databases

BRENDA2.8.4.1. 7358.

Family and domain databases

InterProIPR003178. Me_CoM_Rdtase_gsu.
[Graphical view]
Gene3DG3DSA:3.90.320.20. MCR_gamma. 1 hit.
PfamPF02240. MCR_gamma. 1 hit.
[Graphical view]
PIRSFPIRSF000264. Meth_CoM_rd_gama. 1 hit.
ProDomPD005845. MCR_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR03259. met_CoM_red_gam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMCRZ_METFE
AccessionPrimary (citable) accession number: Q49173
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: November 1, 1996
Last modified: September 22, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents