Q49173 (MCRZ_METFV) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 61.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Methyl-coenzyme M reductase II subunit gamma Short name=MCR II gamma EC=2.8.4.1 Alternative name(s): Coenzyme-B sulfoethylthiotransferase gamma | ||||||
| Gene names |
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| Organism | Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 523846 [NCBI] | ||||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanothermaceae › Methanothermus |
Protein attributes
| Sequence length | 267 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and an heterodisulfide. |
| Catalytic activity | Methyl-CoM + CoB = CoM-S-S-CoB + methane. |
| Cofactor | Binds 2 coenzyme F430 noncovalently per hexamer. Coenzyme F430 is a yellow nickel porphinoid By similarity. |
| Pathway | One-carbon metabolism; methyl-coenzyme M reduction; methane from methyl-coenzyme M: step 1/1. |
| Subunit structure | Hexamer of two alpha, two beta, and two gamma chains By similarity. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Methanogenesis |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | coenzyme-B sulfoethylthiotransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 267 | 267 | Methyl-coenzyme M reductase II subunit gamma | PRO_0000147475 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization and phylogeny of mcrII, a gene cluster encoding an isoenzyme of methyl coenzyme M reductase from hyperthermophilic Methanothermus fervidus." Lehmacher A., Klenk H.-P. Mol. Gen. Genet. 243:198-206(1994) [PubMed: 8177216] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 43054 / DSM 2088 / JCM 10308 / V24 S. |
| [2] | "Complete genome sequence of Methanothermus fervidus type strain (V24S)." Anderson I., Djao O.D., Misra M., Chertkov O., Nolan M., Lucas S., Lapidus A., Del Rio T.G., Tice H., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K., Mikhailova N. Kyrpides N.C.Stand. Genomic Sci. 3:315-324(2010) [PubMed: 21304736] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43054 / DSM 2088 / JCM 10308 / V24 S. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X70765 Genomic DNA. Translation: CAA50043.1. CP002278 Genomic DNA. Translation: ADP77532.1. |
| PIR | S43900. |
| RefSeq | YP_004004294.1. NC_014658.1. |
3D structure databases | |
| ProteinModelPortal | Q49173. |
| SMR | Q49173. Positions 6-251. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 9962463. |
| GenomeReviews | Gene locus Mfer_0733 in contig CP002278_GR. |
| KEGG | mfv:Mfer_0733. |
Organism-specific databases | |
| CMR | Search... |
Family and domain databases | |
| InterPro | IPR009024. Me_CoM_Rdtase_Fd-like_fold. IPR003178. Me_CoM_Rdtase_gsu. [Graphical view] |
| Gene3D | G3DSA:3.90.320.20. MCR_gamma. 1 hit. |
| KO | K00402. |
| Pfam | PF02240. MCR_gamma. 1 hit. [Graphical view] |
| PIRSF | PIRSF000264. Meth_CoM_rd_gama. 1 hit. |
| ProDom | PD005845. Me_CoM_Rdtase_gsu. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SUPFAM | SSF55088. MCR_fer_like. 1 hit. |
| TIGRFAMs | TIGR03259. Met_CoM_red_gam. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MCRZ_METFV | ||||||||
| Accession | Primary (citable) accession number: Q49173 Secondary accession number(s): E3GZ00 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |

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