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Protein

Methyl-coenzyme M reductase II subunit gamma

Gene

mrtG

Organism
Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathway:imethyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase II subunit alpha (mrtA), Methyl-coenzyme M reductase II subunit gamma (mrtG), Methyl-coenzyme M reductase II subunit beta (mrtB)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Methanogenesis

Enzyme and pathway databases

BioCyciMFER523846:GC24-762-MONOMER.
UniPathwayiUPA00646; UER00699.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase II subunit gamma (EC:2.8.4.1)
Short name:
MCR II gamma
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase gamma
Gene namesi
Name:mrtG
Synonyms:mcrIIG
Ordered Locus Names:Mfer_0733
OrganismiMethanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Taxonomic identifieri523846 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus
ProteomesiUP000002315 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Methyl-coenzyme M reductase II subunit gammaPRO_0000147475Add
BLAST

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.By similarity

Protein-protein interaction databases

STRINGi523846.Mfer_0733.

Structurei

3D structure databases

ProteinModelPortaliQ49173.
SMRiQ49173. Positions 6-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000225820.
KOiK00402.
OMAiHRNPGES.

Family and domain databases

Gene3Di3.90.320.20. 1 hit.
InterProiIPR009024. Me_CoM_Rdtase_Fd-like_fold.
IPR003178. Me_CoM_Rdtase_gsu.
[Graphical view]
PfamiPF02240. MCR_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000264. Meth_CoM_rd_gama. 1 hit.
ProDomiPD005845. Me_CoM_Rdtase_gsu. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03259. met_CoM_red_gam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYEPQFNPG ETKIAENRRK HMNPNYELKK LREIADEDIV RVLGHRSPGE
60 70 80 90 100
SFKTVHPPLE EMDFEEDPMK DIVEPIEGAK QGTRIRYIQF ADSMYNAPAQ
110 120 130 140 150
PYDRARTYMW RFRGVDTGTL SGRQVIEMRE LDLEKVSKIL LETEIFDPAR
160 170 180 190 200
CGIRGATVHG HSLRFDENGL MFDALQRYIY DEDSGHVVYV KDQVGRPLDQ
210 220 230 240 250
PVDMGEPLPE DELKEITTIY RKDNIGMRED EELLEVVNKI HEARTIGGFG
260
MEVFKKDLNK RLGGANE
Length:267
Mass (Da):30,847
Last modified:November 1, 1996 - v1
Checksum:i150D5FFAE6BC6F9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70765 Genomic DNA. Translation: CAA50043.1.
CP002278 Genomic DNA. Translation: ADP77532.1.
PIRiS43900.
RefSeqiWP_013413810.1. NC_014658.1.
YP_004004294.1. NC_014658.1.

Genome annotation databases

EnsemblBacteriaiADP77532; ADP77532; Mfer_0733.
GeneIDi9962463.
KEGGimfv:Mfer_0733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70765 Genomic DNA. Translation: CAA50043.1.
CP002278 Genomic DNA. Translation: ADP77532.1.
PIRiS43900.
RefSeqiWP_013413810.1. NC_014658.1.
YP_004004294.1. NC_014658.1.

3D structure databases

ProteinModelPortaliQ49173.
SMRiQ49173. Positions 6-251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi523846.Mfer_0733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADP77532; ADP77532; Mfer_0733.
GeneIDi9962463.
KEGGimfv:Mfer_0733.

Phylogenomic databases

HOGENOMiHOG000225820.
KOiK00402.
OMAiHRNPGES.

Enzyme and pathway databases

UniPathwayiUPA00646; UER00699.
BioCyciMFER523846:GC24-762-MONOMER.

Family and domain databases

Gene3Di3.90.320.20. 1 hit.
InterProiIPR009024. Me_CoM_Rdtase_Fd-like_fold.
IPR003178. Me_CoM_Rdtase_gsu.
[Graphical view]
PfamiPF02240. MCR_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000264. Meth_CoM_rd_gama. 1 hit.
ProDomiPD005845. Me_CoM_Rdtase_gsu. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03259. met_CoM_red_gam. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and phylogeny of mcrII, a gene cluster encoding an isoenzyme of methyl coenzyme M reductase from hyperthermophilic Methanothermus fervidus."
    Lehmacher A., Klenk H.-P.
    Mol. Gen. Genet. 243:198-206(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43054 / DSM 2088 / JCM 10308 / V24 S.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43054 / DSM 2088 / JCM 10308 / V24 S.

Entry informationi

Entry nameiMCRZ_METFV
AccessioniPrimary (citable) accession number: Q49173
Secondary accession number(s): E3GZ00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.