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Protein

Methyl-coenzyme M reductase II subunit beta

Gene

mrtB

Organism
Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.By similarity

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi

GO - Molecular functioni

  1. coenzyme-B sulfoethylthiotransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. methanogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Methanogenesis

Enzyme and pathway databases

BioCyciMFER523846:GC24-760-MONOMER.
UniPathwayiUPA00646; UER00699.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase II subunit beta (EC:2.8.4.1)
Short name:
MCR II beta
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase beta
Gene namesi
Name:mrtB
Synonyms:mcrIIB
Ordered Locus Names:Mfer_0731
OrganismiMethanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Taxonomic identifieri523846 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus
ProteomesiUP000002315: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Methyl-coenzyme M reductase II subunit betaPRO_0000147464Add
BLAST

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ49171.
SMRiQ49171. Positions 2-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000225842.
KOiK00401.
OMAiWALWNAY.

Family and domain databases

Gene3Di1.20.840.10. 2 hits.
3.30.70.470. 1 hit.
InterProiIPR022681. MCR_a/b_chain_a-bundle.
IPR008924. Me_CoM_Rdtase_asu/bsu_C.
IPR015823. Me_CoM_Rdtase_asu_N_sub2.
IPR003179. Me_CoM_Rdtase_bsu.
IPR022679. Me_CoM_Rdtase_bsu_C.
IPR022680. Me_CoM_Rdtase_bsu_N.
IPR009024. Me_CoM_Rdtase_Fd-like_fold.
[Graphical view]
PfamiPF02241. MCR_beta. 1 hit.
PF02783. MCR_beta_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000263. Meth_CoM_rd_beta. 1 hit.
SUPFAMiSSF48081. SSF48081. 1 hit.
SSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03257. met_CoM_red_bet. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49171-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIYEDKIDL YDANGKLLDE NVPLEAISPL KNPTIGKIVN DVKRSVAVNL
60 70 80 90 100
AGIENSLKKA ALGGKANFIP GRELDLDIVE NAEIIAEKIK KMVQVDENDD
110 120 130 140 150
TNVKMINNGQ QLLVQVPTIR IERAADYTVS TLVAGAATIQ AIIDTFDVDM
160 170 180 190 200
FDASTVKTAV LGRYPQTVDF TGANVAAMLS PPVLLEGLGY GLRNILTNHI
210 220 230 240 250
VATTKKNTLN AAALSSILEQ TAMFETGDAV GAFERLHLLG LAYQGLNADN
260 270 280 290 300
LVYDLVKENK KGTVGTVIAS LVERAIEDKV IKVSKEMPSG FRVYEPIDWA
310 320 330 340 350
LWNAYAAAGL LAATIVNIGA ARAAQGVAST VLYYNDILEY ETGLPGVDFG
360 370 380 390 400
RAEGTAVGFS FFSHSIYGGG GPGIFHGNHV VTRHSKGFAL PCVAAAMSLD
410 420 430 440
AGTQMFSPER TSGLVGQVYS EIDYFREPIK YVAEGAAKIK NKI
Length:443
Mass (Da):47,447
Last modified:November 1, 1996 - v1
Checksum:iFEAA6DDD20A262E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70765 Genomic DNA. Translation: CAA50041.1.
CP002278 Genomic DNA. Translation: ADP77530.1.
M99219 Genomic DNA. Translation: AAA73384.1.
PIRiS43899.
RefSeqiWP_013413808.1. NC_014658.1.
YP_004004292.1. NC_014658.1.

Genome annotation databases

EnsemblBacteriaiADP77530; ADP77530; Mfer_0731.
GeneIDi9962461.
KEGGimfv:Mfer_0731.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70765 Genomic DNA. Translation: CAA50041.1.
CP002278 Genomic DNA. Translation: ADP77530.1.
M99219 Genomic DNA. Translation: AAA73384.1.
PIRiS43899.
RefSeqiWP_013413808.1. NC_014658.1.
YP_004004292.1. NC_014658.1.

3D structure databases

ProteinModelPortaliQ49171.
SMRiQ49171. Positions 2-443.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADP77530; ADP77530; Mfer_0731.
GeneIDi9962461.
KEGGimfv:Mfer_0731.

Phylogenomic databases

HOGENOMiHOG000225842.
KOiK00401.
OMAiWALWNAY.

Enzyme and pathway databases

UniPathwayiUPA00646; UER00699.
BioCyciMFER523846:GC24-760-MONOMER.

Family and domain databases

Gene3Di1.20.840.10. 2 hits.
3.30.70.470. 1 hit.
InterProiIPR022681. MCR_a/b_chain_a-bundle.
IPR008924. Me_CoM_Rdtase_asu/bsu_C.
IPR015823. Me_CoM_Rdtase_asu_N_sub2.
IPR003179. Me_CoM_Rdtase_bsu.
IPR022679. Me_CoM_Rdtase_bsu_C.
IPR022680. Me_CoM_Rdtase_bsu_N.
IPR009024. Me_CoM_Rdtase_Fd-like_fold.
[Graphical view]
PfamiPF02241. MCR_beta. 1 hit.
PF02783. MCR_beta_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000263. Meth_CoM_rd_beta. 1 hit.
SUPFAMiSSF48081. SSF48081. 1 hit.
SSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03257. met_CoM_red_bet. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and phylogeny of mcrII, a gene cluster encoding an isoenzyme of methyl coenzyme M reductase from hyperthermophilic Methanothermus fervidus."
    Lehmacher A., Klenk H.-P.
    Mol. Gen. Genet. 243:198-206(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43054 / DSM 2088 / JCM 10308 / V24 S.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43054 / DSM 2088 / JCM 10308 / V24 S.
  3. Steigerwald V.J., Stroup D., Hennigan A.N., Pihl T.D., Reeve J.N.
    Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125.

Entry informationi

Entry nameiMCRY_METFV
AccessioniPrimary (citable) accession number: Q49171
Secondary accession number(s): E3GYZ8, Q49177
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.