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Protein

Methyl-coenzyme M reductase II subunit beta

Gene

mrtB

Organism
Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.By similarity

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi: methyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase subunit gamma (Mfer_0785), Methyl-coenzyme M reductase subunit alpha (Mfer_0784), Methyl-coenzyme M reductase II subunit alpha (mrtA), Methyl-coenzyme M reductase II subunit gamma (mrtG), Methyl-coenzyme M reductase II subunit beta (mrtB), Methyl-coenzyme M reductase subunit beta (Mfer_0788)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMethanogenesis

Enzyme and pathway databases

BioCyciMFER523846:G1GOR-755-MONOMER
UniPathwayiUPA00646; UER00699

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase II subunit beta (EC:2.8.4.1)
Short name:
MCR II beta
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase beta
Gene namesi
Name:mrtB
Synonyms:mcrIIB
Ordered Locus Names:Mfer_0731
OrganismiMethanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Taxonomic identifieri523846 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus
Proteomesi
  • UP000002315 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001474641 – 443Methyl-coenzyme M reductase II subunit betaAdd BLAST443

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.By similarity

Protein-protein interaction databases

STRINGi523846.Mfer_0731

Structurei

3D structure databases

ProteinModelPortaliQ49171
SMRiQ49171
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiarCOG04860 Archaea
COG4054 LUCA
HOGENOMiHOG000225842
KOiK00401
OMAiWALWNAY
OrthoDBiPOG093Z033X

Family and domain databases

Gene3Di1.20.840.10, 2 hits
3.30.70.470, 1 hit
InterProiView protein in InterPro
IPR008924 Me_CoM_Rdtase_asu/bsu_C
IPR015823 Me_CoM_Rdtase_asu_N_sub2
IPR003179 Me_CoM_Rdtase_bsu
IPR022679 Me_CoM_Rdtase_bsu_C
IPR022680 Me_CoM_Rdtase_bsu_N
IPR009024 Me_CoM_Rdtase_Fd-like_fold
PfamiView protein in Pfam
PF02241 MCR_beta, 1 hit
PF02783 MCR_beta_N, 1 hit
PIRSFiPIRSF000263 Meth_CoM_rd_beta, 1 hit
SUPFAMiSSF48081 SSF48081, 1 hit
SSF55088 SSF55088, 1 hit
TIGRFAMsiTIGR03257 met_CoM_red_bet, 1 hit

Sequencei

Sequence statusi: Complete.

Q49171-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIYEDKIDL YDANGKLLDE NVPLEAISPL KNPTIGKIVN DVKRSVAVNL
60 70 80 90 100
AGIENSLKKA ALGGKANFIP GRELDLDIVE NAEIIAEKIK KMVQVDENDD
110 120 130 140 150
TNVKMINNGQ QLLVQVPTIR IERAADYTVS TLVAGAATIQ AIIDTFDVDM
160 170 180 190 200
FDASTVKTAV LGRYPQTVDF TGANVAAMLS PPVLLEGLGY GLRNILTNHI
210 220 230 240 250
VATTKKNTLN AAALSSILEQ TAMFETGDAV GAFERLHLLG LAYQGLNADN
260 270 280 290 300
LVYDLVKENK KGTVGTVIAS LVERAIEDKV IKVSKEMPSG FRVYEPIDWA
310 320 330 340 350
LWNAYAAAGL LAATIVNIGA ARAAQGVAST VLYYNDILEY ETGLPGVDFG
360 370 380 390 400
RAEGTAVGFS FFSHSIYGGG GPGIFHGNHV VTRHSKGFAL PCVAAAMSLD
410 420 430 440
AGTQMFSPER TSGLVGQVYS EIDYFREPIK YVAEGAAKIK NKI
Length:443
Mass (Da):47,447
Last modified:November 1, 1996 - v1
Checksum:iFEAA6DDD20A262E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70765 Genomic DNA Translation: CAA50041.1
CP002278 Genomic DNA Translation: ADP77530.1
M99219 Genomic DNA Translation: AAA73384.1
PIRiS43899
RefSeqiWP_013413808.1, NC_014658.1

Genome annotation databases

EnsemblBacteriaiADP77530; ADP77530; Mfer_0731
GeneIDi9962461
KEGGimfv:Mfer_0731

Similar proteinsi

Entry informationi

Entry nameiMCRY_METFV
AccessioniPrimary (citable) accession number: Q49171
Secondary accession number(s): E3GYZ8, Q49177
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health