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Q49171

- MCRY_METFV

UniProt

Q49171 - MCRY_METFV

Protein

Methyl-coenzyme M reductase II subunit beta

Gene

mrtB

Organism
Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.By similarity

    Catalytic activityi

    Methyl-CoM + CoB = CoM-S-S-CoB + methane.

    Pathwayi

    GO - Molecular functioni

    1. coenzyme-B sulfoethylthiotransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. methanogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Methanogenesis

    Enzyme and pathway databases

    BioCyciMFER523846:GC24-760-MONOMER.
    UniPathwayiUPA00646; UER00699.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyl-coenzyme M reductase II subunit beta (EC:2.8.4.1)
    Short name:
    MCR II beta
    Alternative name(s):
    Coenzyme-B sulfoethylthiotransferase beta
    Gene namesi
    Name:mrtB
    Synonyms:mcrIIB
    Ordered Locus Names:Mfer_0731
    OrganismiMethanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
    Taxonomic identifieri523846 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus
    ProteomesiUP000002315: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Methyl-coenzyme M reductase II subunit betaPRO_0000147464Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer of two alpha, two beta, and two gamma chains.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ49171.
    SMRiQ49171. Positions 2-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000225842.
    KOiK00401.
    OMAiWALWNAY.

    Family and domain databases

    Gene3Di1.20.840.10. 2 hits.
    3.30.70.470. 1 hit.
    InterProiIPR022681. MCR_a/b_chain_a-bundle.
    IPR008924. Me_CoM_Rdtase_asu/bsu_C.
    IPR015823. Me_CoM_Rdtase_asu_N_sub2.
    IPR003179. Me_CoM_Rdtase_bsu.
    IPR022679. Me_CoM_Rdtase_bsu_C.
    IPR022680. Me_CoM_Rdtase_bsu_N.
    IPR009024. Me_CoM_Rdtase_Fd-like_fold.
    [Graphical view]
    PfamiPF02241. MCR_beta. 1 hit.
    PF02783. MCR_beta_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000263. Meth_CoM_rd_beta. 1 hit.
    SUPFAMiSSF48081. SSF48081. 1 hit.
    SSF55088. SSF55088. 1 hit.
    TIGRFAMsiTIGR03257. met_CoM_red_bet. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q49171-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIYEDKIDL YDANGKLLDE NVPLEAISPL KNPTIGKIVN DVKRSVAVNL    50
    AGIENSLKKA ALGGKANFIP GRELDLDIVE NAEIIAEKIK KMVQVDENDD 100
    TNVKMINNGQ QLLVQVPTIR IERAADYTVS TLVAGAATIQ AIIDTFDVDM 150
    FDASTVKTAV LGRYPQTVDF TGANVAAMLS PPVLLEGLGY GLRNILTNHI 200
    VATTKKNTLN AAALSSILEQ TAMFETGDAV GAFERLHLLG LAYQGLNADN 250
    LVYDLVKENK KGTVGTVIAS LVERAIEDKV IKVSKEMPSG FRVYEPIDWA 300
    LWNAYAAAGL LAATIVNIGA ARAAQGVAST VLYYNDILEY ETGLPGVDFG 350
    RAEGTAVGFS FFSHSIYGGG GPGIFHGNHV VTRHSKGFAL PCVAAAMSLD 400
    AGTQMFSPER TSGLVGQVYS EIDYFREPIK YVAEGAAKIK NKI 443
    Length:443
    Mass (Da):47,447
    Last modified:November 1, 1996 - v1
    Checksum:iFEAA6DDD20A262E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70765 Genomic DNA. Translation: CAA50041.1.
    CP002278 Genomic DNA. Translation: ADP77530.1.
    M99219 Genomic DNA. Translation: AAA73384.1.
    PIRiS43899.
    RefSeqiWP_013413808.1. NC_014658.1.
    YP_004004292.1. NC_014658.1.

    Genome annotation databases

    EnsemblBacteriaiADP77530; ADP77530; Mfer_0731.
    GeneIDi9962461.
    KEGGimfv:Mfer_0731.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70765 Genomic DNA. Translation: CAA50041.1 .
    CP002278 Genomic DNA. Translation: ADP77530.1 .
    M99219 Genomic DNA. Translation: AAA73384.1 .
    PIRi S43899.
    RefSeqi WP_013413808.1. NC_014658.1.
    YP_004004292.1. NC_014658.1.

    3D structure databases

    ProteinModelPortali Q49171.
    SMRi Q49171. Positions 2-443.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADP77530 ; ADP77530 ; Mfer_0731 .
    GeneIDi 9962461.
    KEGGi mfv:Mfer_0731.

    Phylogenomic databases

    HOGENOMi HOG000225842.
    KOi K00401.
    OMAi WALWNAY.

    Enzyme and pathway databases

    UniPathwayi UPA00646 ; UER00699 .
    BioCyci MFER523846:GC24-760-MONOMER.

    Family and domain databases

    Gene3Di 1.20.840.10. 2 hits.
    3.30.70.470. 1 hit.
    InterProi IPR022681. MCR_a/b_chain_a-bundle.
    IPR008924. Me_CoM_Rdtase_asu/bsu_C.
    IPR015823. Me_CoM_Rdtase_asu_N_sub2.
    IPR003179. Me_CoM_Rdtase_bsu.
    IPR022679. Me_CoM_Rdtase_bsu_C.
    IPR022680. Me_CoM_Rdtase_bsu_N.
    IPR009024. Me_CoM_Rdtase_Fd-like_fold.
    [Graphical view ]
    Pfami PF02241. MCR_beta. 1 hit.
    PF02783. MCR_beta_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000263. Meth_CoM_rd_beta. 1 hit.
    SUPFAMi SSF48081. SSF48081. 1 hit.
    SSF55088. SSF55088. 1 hit.
    TIGRFAMsi TIGR03257. met_CoM_red_bet. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and phylogeny of mcrII, a gene cluster encoding an isoenzyme of methyl coenzyme M reductase from hyperthermophilic Methanothermus fervidus."
      Lehmacher A., Klenk H.-P.
      Mol. Gen. Genet. 243:198-206(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 43054 / DSM 2088 / JCM 10308 / V24 S.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43054 / DSM 2088 / JCM 10308 / V24 S.
    3. Steigerwald V.J., Stroup D., Hennigan A.N., Pihl T.D., Reeve J.N.
      Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125.

    Entry informationi

    Entry nameiMCRY_METFV
    AccessioniPrimary (citable) accession number: Q49171
    Secondary accession number(s): E3GYZ8, Q49177
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3