Reviewed,
UniProtKB/Swiss-Prot Q49150 (PQQCD_METEX)
Last modified
November 4, 2008.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Bifunctional coenzyme PQQ synthesis protein C/D Alternative name(s): Pyrroloquinoline quinone biosynthesis protein C/D Including the following 2 domains: 1- Recommended name: Pyrroloquinoline-quinone synthase EC=1.3.3.11 Alternative name(s): Coenzyme PQQ synthesis protein C 2- Recommended name: Coenzyme PQQ synthesis protein D | ||
| Gene names |
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| Organism | Methylobacterium extorquens (Protomonas extorquens) | ||
| Taxonomic identifier | 408 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium |
Protein attributes
| Sequence length | 372 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity. |
| Catalytic activity | 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O(2) = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H(2)O(2) + 2 H(2)O. |
| Pathway | Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. |
| Sequence similarities | In the N-terminal section; belongs to the pqqC family. In the C-terminal section; belongs to the pqqD family. |
Ontologies
Keywords | |
|---|---|
| Biological process | PQQ biosynthesis |
| Molecular function | Oxidoreductase |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyrroloquinoline quinone biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Isolation, phenotypic characterization, and complementation analysis of mutants of Methylobacterium extorquens AM1 unable to synthesize pyrroloquinoline quinone and sequences of pqqD, pqqG, and pqqC." Morris C.J., Biville F., Turlin E., Lee E., Ellermann K., Fan W.H., Ramamoorthi R., Springer A.L., Lidstrom M.E. J. Bacteriol. 176:1746-1755(1994) [PubMed: 8132470] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-111. Strain: AM1 / NCIMB 9133. |
| [2] | "Sequence analysis of pqq genes required for biosynthesis of pyrroloquinoline quinone in Methylobacterium extorquens AM1 and the purification of a biosynthetic intermediate." Toyama H., Chistoserdova L., Lidstrom M.E. Microbiology 143:595-602(1997) [PubMed: 9043136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 110-372. Strain: AM1 / NCIMB 9133. |
Cross-references
Sequence databases | |
|---|---|
| L25889 Unassigned DNA. Translation: AAA17880.1. U72662 Genomic DNA. Translation: AAB58899.1. | |
| PIR | C55527. |
3D structure databases | |
| ModBase | Search... |
Family and domain databases | |
| HAMAP | MF_00654. Fused. [Tree] MF_00655. Fused. [Tree] |
| InterPro | IPR016084. Haem_Oase-like_multi-hlx. IPR011845. PQQ_synth_PqqC. IPR008792. PQQ_synth_PqqD. IPR004305. TENA/THI4/PQQ_synth_PqqC. [Graphical view] |
| Gene3D | G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit. |
| Pfam | PF05402. PqqD. 1 hit. PF03070. TENA_THI-4. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR02111. PQQ_syn_pqqC. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PQQCD_METEX | ||||||||
| Accession | Primary (citable) accession number: Q49150 Secondary accession number(s): P71518 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


