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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.By similarity

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei142PROSITE-ProRule annotation1
Active sitei581PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-3824.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
Short name:
PEPC
Short name:
PEPCase
Gene namesi
Name:ppc
Synonyms:ppcA
Ordered Locus Names:MexAM1_META1p1732
OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)
Taxonomic identifieri272630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000009081 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001665991 – 922Phosphoenolpyruvate carboxylaseAdd BLAST922

Interactioni

Protein-protein interaction databases

STRINGi272630.MexAM1_META1p1732.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.Curated

Phylogenomic databases

eggNOGiENOG4105CCA. Bacteria.
COG2352. LUCA.
HOGENOMiHOG000238647.
KOiK01595.
OMAiKFRRIYL.

Family and domain databases

InterProiIPR021135. PEP_COase.
IPR033129. PEPCASE_His_AS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTLHARPS AATDTTFAPP VITGTATEDA LEILFHALLD VARRHDPELE
60 70 80 90 100
DVLHGRADIS SFTPEMLARA LQVQGIWFQL VSIAEQNAAM RRRRHVERDQ
110 120 130 140 150
GREALNGSFA KVLAEASARG IGPQQIHALL KDLRIRPTIT AHPTEGKRVT
160 170 180 190 200
VLEKLRRIYL VLRELELPRW TERERNGLMN ELRDQIELIW MTGELHLEKA
210 220 230 240 250
TVEREVAWGL HFFDETLFEM LPEMLLSLEE SLAQYYPDET FEVPPFFQFG
260 270 280 290 300
SWIGGDRDGN PYVTASVTRE TLQRNALASL RRYRDGITHL GRVLSITERS
310 320 330 340 350
LPVPETFRSE LAHMLAESGD ARAIANRNPG EAYRQFLSCV LRKLEATIAR
360 370 380 390 400
NKGARSVGPD YPSADGLIND LRTLEKGLAD AKCGALATDI VRPVRRMVEI
410 420 430 440 450
FRFSTVRLDL RENSTRTTKT LHALWKLRNG DREPPALDSP AWKDWLLTEL
460 470 480 490 500
ARPRTPETSF EDFADRLPDD ARETLATFAL VGEMRDTLDR EAFGAFILSM
510 520 530 540 550
TRSTVDVLGA YLLAKEAGIF LDTTGTEICP LPIVPLFETI DDLRAAPAIM
560 570 580 590 600
KELLGIPVVR RSTRWQGGVQ EVMIGYSDSN KDGGFIASNW ELYKAQVRLT
610 620 630 640 650
TLGNHLGVPI AFFHGRGGSV SRGGVPTHRG IAAQPPGSIQ GRFRITEQGE
660 670 680 690 700
VVSFKYANRG TAAYQMELLA ASVFEHALLS EGNGNGSRAE FDDALEALSG
710 720 730 740 750
ASRAAYVNLL QAEGLVDYFQ AASPLDEISL LNIGSRPARR FGAKSLSDLR
760 770 780 790 800
AIPWVFAWSQ NRHVITGWYG VGSGLKSFID VRGEAGEALL RRLFRDCRVF
810 820 830 840 850
RLVLDEVEKT LLMVDLEIAR DYAGLVEDAG IRARIFGMIE AEYALTREMV
860 870 880 890 900
LRVSGDSELA QRFPQFSERL RGRLPTINQV SREQVELLRR YRSETDEDKR
910 920
EAVKSALLLS INCIAVGFGA TG
Length:922
Mass (Da):103,021
Last modified:September 22, 2009 - v2
Checksum:i11B90AD09BB5683E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28E → A in AAA62656 (PubMed:7961516).Curated1
Sequence conflicti506D → E in AAB58883 (PubMed:9168622).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72662 Genomic DNA. Translation: AAB58883.2.
CP001510 Genomic DNA. Translation: ACS39576.1.
L33465 Genomic DNA. Translation: AAA62656.1.
PIRiD55230.
RefSeqiWP_003597630.1. NC_012808.1.

Genome annotation databases

EnsemblBacteriaiACS39576; ACS39576; MexAM1_META1p1732.
KEGGimea:Mex_1p1732.
PATRICi22509294. VBIMetExt101010_1722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72662 Genomic DNA. Translation: AAB58883.2.
CP001510 Genomic DNA. Translation: ACS39576.1.
L33465 Genomic DNA. Translation: AAA62656.1.
PIRiD55230.
RefSeqiWP_003597630.1. NC_012808.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272630.MexAM1_META1p1732.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS39576; ACS39576; MexAM1_META1p1732.
KEGGimea:Mex_1p1732.
PATRICi22509294. VBIMetExt101010_1722.

Phylogenomic databases

eggNOGiENOG4105CCA. Bacteria.
COG2352. LUCA.
HOGENOMiHOG000238647.
KOiK01595.
OMAiKFRRIYL.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-3824.

Family and domain databases

InterProiIPR021135. PEP_COase.
IPR033129. PEPCASE_His_AS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAPP_METEA
AccessioniPrimary (citable) accession number: Q49136
Secondary accession number(s): C5B112, P71502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 22, 2009
Last modified: November 2, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.