Q49136 (CAPP_METEA) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 64.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Phosphoenolpyruvate carboxylase Short name=PEPC Short name=PEPCase EC=4.1.1.31 | ||||||
| Gene names |
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| Organism | Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 272630 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium ›  |
Protein attributes
| Sequence length | 922 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_00595 |
| Catalytic activity | Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_00595 |
| Cofactor | Magnesium By similarity. |
| Sequence similarities | Belongs to the PEPCase type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carbon dioxide fixation |
| Ligand | Magnesium |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | carbon fixation Inferred from electronic annotation. Source: HAMAP oxaloacetate metabolic processInferred from electronic annotation. Source: HAMAP tricarboxylic acid cycleInferred from electronic annotation. Source: InterPro |
| Molecular_function | magnesium ion binding Inferred from electronic annotation. Source: HAMAP phosphoenolpyruvate carboxylase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 922 | 922 | Phosphoenolpyruvate carboxylase HAMAP-Rule MF_00595 | PRO_0000166599 | |||||
Sites | |||||||||
| Active site | 142 | 1 | By similarity | ||||||
| Active site | 581 | 1 | By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 28 | 1 | E → A in AAA62656. Ref.3 | ||||||
| Sequence conflict | 506 | 1 | D → E in AAB58883. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular and mutational analysis of a DNA region separating two methylotrophy gene clusters in Methylobacterium extorquens AM1." Chistoserdova L.V., Lidstrom M.E. Microbiology 143:1729-1736(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources." Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y., Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W., Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E.  Lidstrom M.E.PLoS ONE 4:E5584-E5584(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 14718 / DSM 1338 / AM1. |
| [3] | "Genetics of the serine cycle in Methylobacterium extorquens AM1: identification, sequence, and mutation of three new genes involved in C1 assimilation, orf4, mtkA, and mtkB." Chistoserdova L.V., Lidstrom M.E. J. Bacteriol. 176:7398-7404(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U72662 Genomic DNA. Translation: AAB58883.2. CP001510 Genomic DNA. Translation: ACS39576.1. L33465 Genomic DNA. Translation: AAA62656.1. |
| PIR | D55230. |
| RefSeq | YP_002962853.1. NC_012808.1. |
3D structure databases | |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | ACS39576; ACS39576; MexAM1_META1p1732. |
| GeneID | 7991695. |
| KEGG | mea:Mex_1p1732. |
| PATRIC | 22509294. VBIMetExt101010_1722. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG2352. |
| HOGENOM | HOG000238647. |
| KO | K01595. |
| OMA | RENQMWT. |
| ProtClustDB | CLSK933582. |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:MONOMER-3824. |
Family and domain databases | |
| HAMAP | MF_00595. PEPcase_type1. |
| InterPro | IPR021135. PEP_COase. IPR018129. PEP_COase_AS. IPR022805. PEP_COase_bac/pln-type. IPR015813. Pyrv/PenolPyrv_Kinase. [Graphical view] |
| Pfam | PF00311. PEPcase. 1 hit. [Graphical view] |
| PRINTS | PR00150. PEPCARBXLASE. |
| SUPFAM | SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit. |
| PROSITE | PS00781. PEPCASE_1. False negative. PS00393. PEPCASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CAPP_METEA | ||||||||
| Accession | Primary (citable) accession number: Q49136 Secondary accession number(s): C5B112, P71502 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |