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Q49136

- CAPP_METEA

UniProt

Q49136 - CAPP_METEA

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Protein

Phosphoenolpyruvate carboxylase

Gene
ppc, ppcA, MexAM1_META1p1732
Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei142 – 1421 By similarity
Active sitei581 – 5811 By similarity

GO - Molecular functioni

  1. phosphoenolpyruvate carboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbon fixation Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-3824.
MEXT272630:GBY6-1656-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
Short name:
PEPC
Short name:
PEPCase
Gene namesi
Name:ppc
Synonyms:ppcA
Ordered Locus Names:MexAM1_META1p1732
OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Taxonomic identifieri272630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000009081: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 922922Phosphoenolpyruvate carboxylasePRO_0000166599Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiISCQHYR.
OrthoDBiEOG6TJ7T8.

Family and domain databases

InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49136-1 [UniParc]FASTAAdd to Basket

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MTKTLHARPS AATDTTFAPP VITGTATEDA LEILFHALLD VARRHDPELE    50
DVLHGRADIS SFTPEMLARA LQVQGIWFQL VSIAEQNAAM RRRRHVERDQ 100
GREALNGSFA KVLAEASARG IGPQQIHALL KDLRIRPTIT AHPTEGKRVT 150
VLEKLRRIYL VLRELELPRW TERERNGLMN ELRDQIELIW MTGELHLEKA 200
TVEREVAWGL HFFDETLFEM LPEMLLSLEE SLAQYYPDET FEVPPFFQFG 250
SWIGGDRDGN PYVTASVTRE TLQRNALASL RRYRDGITHL GRVLSITERS 300
LPVPETFRSE LAHMLAESGD ARAIANRNPG EAYRQFLSCV LRKLEATIAR 350
NKGARSVGPD YPSADGLIND LRTLEKGLAD AKCGALATDI VRPVRRMVEI 400
FRFSTVRLDL RENSTRTTKT LHALWKLRNG DREPPALDSP AWKDWLLTEL 450
ARPRTPETSF EDFADRLPDD ARETLATFAL VGEMRDTLDR EAFGAFILSM 500
TRSTVDVLGA YLLAKEAGIF LDTTGTEICP LPIVPLFETI DDLRAAPAIM 550
KELLGIPVVR RSTRWQGGVQ EVMIGYSDSN KDGGFIASNW ELYKAQVRLT 600
TLGNHLGVPI AFFHGRGGSV SRGGVPTHRG IAAQPPGSIQ GRFRITEQGE 650
VVSFKYANRG TAAYQMELLA ASVFEHALLS EGNGNGSRAE FDDALEALSG 700
ASRAAYVNLL QAEGLVDYFQ AASPLDEISL LNIGSRPARR FGAKSLSDLR 750
AIPWVFAWSQ NRHVITGWYG VGSGLKSFID VRGEAGEALL RRLFRDCRVF 800
RLVLDEVEKT LLMVDLEIAR DYAGLVEDAG IRARIFGMIE AEYALTREMV 850
LRVSGDSELA QRFPQFSERL RGRLPTINQV SREQVELLRR YRSETDEDKR 900
EAVKSALLLS INCIAVGFGA TG 922
Length:922
Mass (Da):103,021
Last modified:September 22, 2009 - v2
Checksum:i11B90AD09BB5683E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281E → A in AAA62656. 1 Publication
Sequence conflicti506 – 5061D → E in AAB58883. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U72662 Genomic DNA. Translation: AAB58883.2.
CP001510 Genomic DNA. Translation: ACS39576.1.
L33465 Genomic DNA. Translation: AAA62656.1.
PIRiD55230.
RefSeqiYP_002962853.1. NC_012808.1.

Genome annotation databases

EnsemblBacteriaiACS39576; ACS39576; MexAM1_META1p1732.
GeneIDi7991695.
KEGGimea:Mex_1p1732.
PATRICi22509294. VBIMetExt101010_1722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U72662 Genomic DNA. Translation: AAB58883.2 .
CP001510 Genomic DNA. Translation: ACS39576.1 .
L33465 Genomic DNA. Translation: AAA62656.1 .
PIRi D55230.
RefSeqi YP_002962853.1. NC_012808.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS39576 ; ACS39576 ; MexAM1_META1p1732 .
GeneIDi 7991695.
KEGGi mea:Mex_1p1732.
PATRICi 22509294. VBIMetExt101010_1722.

Phylogenomic databases

eggNOGi COG2352.
HOGENOMi HOG000238647.
KOi K01595.
OMAi ISCQHYR.
OrthoDBi EOG6TJ7T8.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-3824.
MEXT272630:GBY6-1656-MONOMER.

Family and domain databases

InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and mutational analysis of a DNA region separating two methylotrophy gene clusters in Methylobacterium extorquens AM1."
    Chistoserdova L.V., Lidstrom M.E.
    Microbiology 143:1729-1736(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14718 / DSM 1338 / AM1.
  3. "Genetics of the serine cycle in Methylobacterium extorquens AM1: identification, sequence, and mutation of three new genes involved in C1 assimilation, orf4, mtkA, and mtkB."
    Chistoserdova L.V., Lidstrom M.E.
    J. Bacteriol. 176:7398-7404(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.

Entry informationi

Entry nameiCAPP_METEA
AccessioniPrimary (citable) accession number: Q49136
Secondary accession number(s): C5B112, P71502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 22, 2009
Last modified: May 14, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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