ID   DHMH_METEX              Reviewed;         411 AA.
AC   Q49124;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 47.
DE   RecName: Full=Methylamine dehydrogenase heavy chain;
DE            Short=MADH;
DE            EC=1.4.99.3;
DE   Flags: Precursor;
GN   Name=mauB;
OS   Methylobacterium extorquens (Protomonas extorquens).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=408;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AM1 / NCIMB 9133;
RX   MEDLINE=94292425; PubMed=8021187;
RA   Chistoserdov A.Y., Chistoserdova L.V., McIntire W.S., Lidstrom M.E.;
RT   "Genetic organization of the mau gene cluster in Methylobacterium
RT   extorquens AM1: complete nucleotide sequence and generation and
RT   characteristics of mau mutants.";
RL   J. Bacteriol. 176:4052-4065(1994).
CC   -!- FUNCTION: Methylamine dehydrogenase carries out the oxidation of
CC       methylamine. Electrons are passed from methylamine dehydrogenase
CC       to amicyanin.
CC   -!- CATALYTIC ACTIVITY: RCH(2)NH(2) + H(2)O + acceptor = RCHO + NH(3)
CC       + reduced acceptor.
CC   -!- SUBUNIT: Tetramer of two light and two heavy chains.
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the aromatic amine dehydrogenase heavy
CC       chain family.
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DR   EMBL; L26406; AAB46933.1; -; Genomic_DNA.
DR   HSSP; P29894; 2MTA.
DR   BioCyc; MetaCyc:MON-3905; -.
DR   BRENDA; 1.4.99.3; 20440.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0030058; F:amine dehydrogenase activity; IEA:EC.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0030416; P:methylamine metabolic process; IEA:InterPro.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013476; MeN_DH_hvc.
DR   InterPro; IPR009451; Metamine_DH_Hsu.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
DR   Pfam; PF06433; Me-amine-dh_H; 1.
DR   PIRSF; PIRSF017797; TTQ_MADH_Hv; 1.
DR   TIGRFAMs; TIGR02658; TTQ_MADH_Hv; 1.
PE   3: Inferred from homology;
KW   Electron transport; Oxidoreductase; Periplasm; Signal; Transport.
FT   SIGNAL        1     36       Potential.
FT   CHAIN        37    411       Methylamine dehydrogenase heavy chain.
FT                                /FTId=PRO_0000025577.
SQ   SEQUENCE   411 AA;  44636 MW;  0899CF454A1F81B9 CRC64;
     MMTHAYTKVR QALCYGSATL GAAALAALIA AGSAAAAESH GVATAKAAAA DLAAGKADDP
     VVLKAAPINA RRVFVYDPKH FAAISQFYMI DGDTARVVGT ADGGFLSNPV VASDGSFFGQ
     ASTVYERIAR GKRTDYVELL DPQTNNPIAD IELPNSPRFL VGTYPWMTAL TPNNKTLLFY
     QFSPQPAVGV VDLAGKKFDR MIEVPDCYHI FPSSNDTFFM HCRDGSLLKV GIGADGKSQT
     KRTEIFHKEN EYLINHPAYS PKSGRLVWPT YTGKIFQIDL SSQDAKFLPA IEAFTDAEKK
     EGWAPGGWQQ VAYHRESDRI FLLGDQRAAS KHKAPSRFLF VIDAKTGKRI NKIELKHEID
     SVGVSQDAKP QLYALSTGDK ALYIFDPETG KEVSSVNQLG AGPQVVMTSD M
//