Reviewed, UniProtKB/Swiss-Prot Q49124 (DHMH_METEX)

Names and origin

Protein names

Recommended name:
    Methylamine dehydrogenase heavy chain
      Short name=MADH
    EC=1.4.99.3

Gene names

Name:

mauB

Organism

Methylobacterium extorquens (Protomonas extorquens)

Taxonomic identifier

408 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Methylamine dehydrogenase carries out the oxidation of methylamine. Electrons are passed from methylamine dehydrogenase to amicyanin.
Catalytic activity	RCH(2)NH(2) + H(2)O + acceptor = RCHO + NH(3) + reduced acceptor.
Subunit structure	Tetramer of two light and two heavy chains.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the aromatic amine dehydrogenase heavy chain family.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Periplasm
Domain	Signal
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW methylamine metabolic process Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	amine dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 36	36	Potential
	Chain	37 – 411	375	Methylamine dehydrogenase heavy chain		PRO_0000025577

Sequences

	Sequence		Length	Mass (Da)
	Q49124-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 0899CF454A1F81B9	FASTA	411	44,636
	10 20 30 40 50 60 MMTHAYTKVR QALCYGSATL GAAALAALIA AGSAAAAESH GVATAKAAAA DLAAGKADDP 70 80 90 100 110 120 VVLKAAPINA RRVFVYDPKH FAAISQFYMI DGDTARVVGT ADGGFLSNPV VASDGSFFGQ 130 140 150 160 170 180 ASTVYERIAR GKRTDYVELL DPQTNNPIAD IELPNSPRFL VGTYPWMTAL TPNNKTLLFY 190 200 210 220 230 240 QFSPQPAVGV VDLAGKKFDR MIEVPDCYHI FPSSNDTFFM HCRDGSLLKV GIGADGKSQT 250 260 270 280 290 300 KRTEIFHKEN EYLINHPAYS PKSGRLVWPT YTGKIFQIDL SSQDAKFLPA IEAFTDAEKK 310 320 330 340 350 360 EGWAPGGWQQ VAYHRESDRI FLLGDQRAAS KHKAPSRFLF VIDAKTGKRI NKIELKHEID 370 380 390 400 410 SVGVSQDAKP QLYALSTGDK ALYIFDPETG KEVSSVNQLG AGPQVVMTSD M

References

[1]

"Genetic organization of the mau gene cluster in Methylobacterium extorquens AM1: complete nucleotide sequence and generation and characteristics of mau mutants." Chistoserdov A.Y., Chistoserdova L.V., McIntire W.S., Lidstrom M.E. J. Bacteriol. 176:4052-4065(1994) [PubMed: 8021187] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AM1 / NCIMB 9133.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L26406 Genomic DNA. Translation: AAB46933.1.
3D structure databases
HSSP	HSSP built from PDB template 2MTA based on UniProtKB P29894.
ModBase	Search...
Enzyme and pathway databases
BioCyc	MetaCyc:MON-3905.
Family and domain databases
InterPro	IPR013476. MeN_DHase_hvc. IPR009451. Metamine_DHase_Hsu. IPR015943. WD40/YVTN_repeat-like. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF06433. Me-amine-dh_H. 1 hit. [Graphical view]
PIRSF	PIRSF017797. TTQ_MADH_Hv. 1 hit.
TIGRFAMs	TIGR02658. TTQ_MADH_Hv. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DHMH_METEX

Accession

Primary (citable) accession number: Q49124

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)