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Reviewed, UniProtKB/Swiss-Prot Q49124 (DHMH_METEX)

Last modified June 16, 2009. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Methylamine dehydrogenase heavy chain
      Short name=MADH
    EC=1.4.99.3
Gene names
Name: mauB
OrganismMethylobacterium extorquens (Protomonas extorquens)
Taxonomic identifier408 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

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Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Methylamine dehydrogenase carries out the oxidation of methylamine. Electrons are passed from methylamine dehydrogenase to amicyanin.

Catalytic activity

RCH2NH2 + H2O + acceptor = RCHO + NH3 + reduced acceptor.

Subunit structure

Tetramer of two light and two heavy chains.

Subcellular location

Periplasm.

Sequence similarities

Belongs to the aromatic amine dehydrogenase heavy chain family.

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Ontologies

Keywords
   Biological processElectron transport
Transport
   Cellular componentPeriplasm
   DomainSignal
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processelectron transport chain

Inferred from electronic annotation. Source: UniProtKB-KW

methylamine metabolic process

Inferred from electronic annotation. Source: InterPro

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentperiplasmic space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionamine dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3636 Potential
Chain37 – 411375Methylamine dehydrogenase heavy chain
PRO_0000025577

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Sequences

Sequence LengthMass (Da)Tools
Q49124-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 0899CF454A1F81B9

FASTA41144,636
        10         20         30         40         50         60 
MMTHAYTKVR QALCYGSATL GAAALAALIA AGSAAAAESH GVATAKAAAA DLAAGKADDP 

        70         80         90        100        110        120 
VVLKAAPINA RRVFVYDPKH FAAISQFYMI DGDTARVVGT ADGGFLSNPV VASDGSFFGQ 

       130        140        150        160        170        180 
ASTVYERIAR GKRTDYVELL DPQTNNPIAD IELPNSPRFL VGTYPWMTAL TPNNKTLLFY 

       190        200        210        220        230        240 
QFSPQPAVGV VDLAGKKFDR MIEVPDCYHI FPSSNDTFFM HCRDGSLLKV GIGADGKSQT 

       250        260        270        280        290        300 
KRTEIFHKEN EYLINHPAYS PKSGRLVWPT YTGKIFQIDL SSQDAKFLPA IEAFTDAEKK 

       310        320        330        340        350        360 
EGWAPGGWQQ VAYHRESDRI FLLGDQRAAS KHKAPSRFLF VIDAKTGKRI NKIELKHEID 

       370        380        390        400        410 
SVGVSQDAKP QLYALSTGDK ALYIFDPETG KEVSSVNQLG AGPQVVMTSD M

« Hide

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References

[1]"Genetic organization of the mau gene cluster in Methylobacterium extorquens AM1: complete nucleotide sequence and generation and characteristics of mau mutants."
Chistoserdov A.Y., Chistoserdova L.V., McIntire W.S., Lidstrom M.E.
J. Bacteriol. 176:4052-4065(1994) [PubMed: 8021187] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AM1 / NCIMB 9133.

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Cross-references

Sequence databases

L26406 Genomic DNA. Translation: AAB46933.1.

3D structure databases

HSSPHSSP built from PDB template 2MTA based on UniProtKB P29894.
ModBaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MON-3905.
BRENDA1.4.99.3. 20440.

Family and domain databases

InterProIPR013476. MeN_DH_hvc.
IPR009451. Metamine_DH_Hsu.
IPR015943. WD40/YVTN_repeat-like.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PfamPF06433. Me-amine-dh_H. 1 hit.
[Graphical view]
PIRSFPIRSF017797. TTQ_MADH_Hv. 1 hit.
TIGRFAMsTIGR02658. TTQ_MADH_Hv. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameDHMH_METEX
AccessionPrimary (citable) accession number: Q49124
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents