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Protein

Acetate kinase

Gene

ackA

Organism
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6MagnesiumUniRule annotation1
Binding sitei13ATPUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Active sitei143Proton donor/acceptorUniRule annotation1
Sitei175Transition state stabilizerUniRule annotation1
Sitei236Transition state stabilizerUniRule annotation1
Metal bindingi380MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 207ATPUniRule annotation5
Nucleotide bindingi278 – 280ATPUniRule annotation3
Nucleotide bindingi326 – 330ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Synonyms:ack
Ordered Locus Names:MCAP_0230
OrganismiMycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Taxonomic identifieri340047 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000001928 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001075841 – 393Acetate kinaseAdd BLAST393

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ49113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000288398.
KOiK00925.
OMAiHRLKKYI.
OrthoDBiPOG091H02K4.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiIPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILVINSGSS SIKFKLFDTS KAIEPILDGL AERIGIDGFL KFEHNNQKYK
60 70 80 90 100
FEDPLPDHEH AIQLILNKLL ELKIISNIDE IKGVGFRVVH GGEISHSSII
110 120 130 140 150
NEEVLQKIQE SVKLAPLHNP AAIIAIKAVK KLMPNTSMIA CFDTAFHQTM
160 170 180 190 200
PQVNYLYSVP YKWYEEFGVR KYGFHGISYE YIVNKCEEIL NKKKEHLNLI
210 220 230 240 250
VCHLGNGASI SCIKDGKSYD TSMGLTPLAG LMMGTRSGDI DVSICEYVAK
260 270 280 290 300
QTNSDIFAIT QILNKQSGLL GLSQTSADMR DVLEQYDRND KKAIIAVEKY
310 320 330 340 350
VQVVADFIVK YANYLDSIDA VVFTAGIGEN ADVIRDLICK RVKLLGLQID
360 370 380 390
QEKNESKYSD YKLISSEKSK IPVYAIRTNE EKMICLDTLN LIK
Length:393
Mass (Da):44,138
Last modified:November 1, 1996 - v1
Checksum:i3F4A0A72843FABAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62057 Genomic DNA. Translation: AAC44347.1.
CP000123 Genomic DNA. Translation: ABC01230.1.
RefSeqiWP_011387118.1. NC_007633.1.

Genome annotation databases

EnsemblBacteriaiABC01230; ABC01230; MCAP_0230.
GeneIDi23778817.
KEGGimcp:MCAP_0230.
PATRICi20004925. VBIMycCap130493_0233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62057 Genomic DNA. Translation: AAC44347.1.
CP000123 Genomic DNA. Translation: ABC01230.1.
RefSeqiWP_011387118.1. NC_007633.1.

3D structure databases

ProteinModelPortaliQ49113.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC01230; ABC01230; MCAP_0230.
GeneIDi23778817.
KEGGimcp:MCAP_0230.
PATRICi20004925. VBIMycCap130493_0233.

Phylogenomic databases

HOGENOMiHOG000288398.
KOiK00925.
OMAiHRLKKYI.
OrthoDBiPOG091H02K4.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiIPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACKA_MYCCT
AccessioniPrimary (citable) accession number: Q49113
Secondary accession number(s): Q2SSP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.