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Q49110

- ODP2_MYCCT

UniProt

Q49110 - ODP2_MYCCT

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Protein
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Gene
pdhC, odp2, MCAP_0227
Organism
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

Cofactori

Binds 1 lipoyl cofactor covalently By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei411 – 4111 Reviewed prediction

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Glycolysis

Enzyme and pathway databases

BioCyciMCAP340047:GC0H-225-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (EC:2.3.1.12)
Alternative name(s):
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
E2
Gene namesi
Name:pdhC
Synonyms:odp2
Ordered Locus Names:MCAP_0227
OrganismiMycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Taxonomic identifieri340047 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001928: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
PRO_0000162280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421N6-lipoyllysine By similarity

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry By similarity.

Protein-protein interaction databases

STRINGi340047.MCAP_0227.

Structurei

3D structure databases

ProteinModelPortaliQ49110.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7575Lipoyl-binding
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Lipoyl

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281564.
KOiK00627.
OMAiEGNTQPP.
OrthoDBiEOG610413.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49110-1 [UniParc]FASTAAdd to Basket

« Hide

MFKVKFADIG EGLTEGTVAE VLVKVGDVVK EGQSLYFVET DKVNSEIPAP    50
VAGKIAVINI KAGQEIKVGD VVMEIEDGSD TSATSEPKAE TKSEAKVEVV 100
EENASVVGAT PVSNDVIVRK QTTTVNKSST IKATPLARKV AADLNIDLSL 150
VTPTGPNQRI LVADIKNHQA SSTQLASQPI SQPAPTPSPS AHQTIAPTIK 200
VVEPSAPLSW DEVPMNGVRK ATVKAMTKSH TEIAAFTGMK NTDITETHKM 250
RTELKDHAAA SGIKLTYLAF IIKAVAKSLR DMPNINVRGD FANNKIQFMH 300
NINIGIAVDT PNGLMVPVIK GADHLSVFEI AIKISELANK AKDGKLTRAE 350
MTEATFTVSN FGSVGLDYAT PIINSPESAI LGVGTMSQTP LYINGELQKR 400
FIMPLSMTCD HRIIDGADAG RFLIKVQDYL SKPVLLFM 438
Length:438
Mass (Da):46,927
Last modified:November 1, 1996 - v1
Checksum:i4BF83B697480B4AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62057 Genomic DNA. Translation: AAC44344.1.
CP000123 Genomic DNA. Translation: ABC01559.1.
RefSeqiWP_011387115.1. NC_007633.1.
YP_424214.1. NC_007633.1.

Genome annotation databases

EnsemblBacteriaiABC01559; ABC01559; MCAP_0227.
GeneIDi3828394.
KEGGimcp:MCAP_0227.
PATRICi20004919. VBIMycCap130493_0230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62057 Genomic DNA. Translation: AAC44344.1 .
CP000123 Genomic DNA. Translation: ABC01559.1 .
RefSeqi WP_011387115.1. NC_007633.1.
YP_424214.1. NC_007633.1.

3D structure databases

ProteinModelPortali Q49110.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340047.MCAP_0227.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC01559 ; ABC01559 ; MCAP_0227 .
GeneIDi 3828394.
KEGGi mcp:MCAP_0227.
PATRICi 20004919. VBIMycCap130493_0230.

Phylogenomic databases

eggNOGi COG0508.
HOGENOMi HOG000281564.
KOi K00627.
OMAi EGNTQPP.
OrthoDBi EOG610413.

Enzyme and pathway databases

BioCyci MCAP340047:GC0H-225-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and organization of genes encoding enzymes involved in pyruvate metabolism in Mycoplasma capricolum."
    Zhu P.P., Peterkofsky A.
    Protein Sci. 5:1719-1736(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: California kid / ATCC 27343 / NCTC 10154.

Entry informationi

Entry nameiODP2_MYCCT
AccessioniPrimary (citable) accession number: Q49110
Secondary accession number(s): Q2SSP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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