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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.By similarity

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131Manganese 2By similarity
Active sitei63 – 631Phosphoserine intermediateBy similarity
Metal bindingi63 – 631Manganese 2By similarity
Metal bindingi420 – 4201Manganese 1By similarity
Metal bindingi424 – 4241Manganese 1By similarity
Metal bindingi462 – 4621Manganese 2By similarity
Metal bindingi463 – 4631Manganese 2By similarity
Metal bindingi480 – 4801Manganese 1By similarity

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glucose catabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciMCAP340047:GC0H-749-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC:5.4.2.12)
Short name:
BPG-independent PGAM
Short name:
Phosphoglyceromutase
Short name:
iPGM
Gene namesi
Name:gpmI
Ordered Locus Names:MCAP_0752
OrganismiMycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Taxonomic identifieri340047 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001928 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5315312,3-bisphosphoglycerate-independent phosphoglycerate mutasePRO_0000212165Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi340047.MCAP_0752.

Structurei

3D structure databases

ProteinModelPortaliQ49006.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0696.
HOGENOMiHOG000223664.
KOiK15633.
OMAiNGGIEKP.
OrthoDBiEOG6HJ22X.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVKRPILLA ILDGWGLAEP DKGNAVDNAN MIFVKQLKQT YPWLKAHASG
60 70 80 90 100
KWVGLPENQM GNSEVGHIHL GAGRINLESL AKLNHETKTN NIAKNDEIVK
110 120 130 140 150
TFEYVKKNNS ALHLMGLFSN GGVHSHFDHM IAIYKAAIVY GITNIKFDLI
160 170 180 190 200
TDGRDTKPKL AYDFIKNLLE LIKQNNNIGI ISSVSGRYYA MDRDKRFDRS
210 220 230 240 250
RIAYNAIVNR NNVRSFTNIL DYIQQEYMIN HDDEMIIPAF NQDDFNGNLK
260 270 280 290 300
ANDAIIMTNF RPDRAIQISS ILTNKNYIAW QSEAFSDAEF IGDKIRFVSM
310 320 330 340 350
MKYSDSVTSP HIAYPPKPLT NTLGQYLSKL GLKQLRIAET EKIAHVTFFF
360 370 380 390 400
DGGNDYFKNG LAKNDEITLA NAYIDLIPSA KVATYDLKPQ MSAVEITDKL
410 420 430 440 450
LEEIKKDEFD FIVLNFANCD MVGHTGNNKA TEIACKTLDD QLKRIHDEFV
460 470 480 490 500
LKHNGIMVIT ADHGNAEIMI DKDDQVNKKH TTSLVPIIIT DKNIKLKQND
510 520 530
PAIAKVAPTI LDLMNIEIPK EMELESMIDH N
Length:531
Mass (Da):60,036
Last modified:March 20, 2006 - v2
Checksum:i4AC56842D6F37724
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000123 Genomic DNA. Translation: ABC01874.1.
Z33087 Genomic DNA. Translation: CAA83752.1.
PIRiS77784.
RefSeqiYP_424703.1. NC_007633.1.

Genome annotation databases

EnsemblBacteriaiABC01874; ABC01874; MCAP_0752.
KEGGimcp:MCAP_0752.
PATRICi20005983. VBIMycCap130493_0733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000123 Genomic DNA. Translation: ABC01874.1.
Z33087 Genomic DNA. Translation: CAA83752.1.
PIRiS77784.
RefSeqiYP_424703.1. NC_007633.1.

3D structure databases

ProteinModelPortaliQ49006.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi340047.MCAP_0752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC01874; ABC01874; MCAP_0752.
KEGGimcp:MCAP_0752.
PATRICi20005983. VBIMycCap130493_0733.

Phylogenomic databases

eggNOGiCOG0696.
HOGENOMiHOG000223664.
KOiK15633.
OMAiNGGIEKP.
OrthoDBiEOG6HJ22X.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.
BioCyciMCAP340047:GC0H-749-MONOMER.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: California kid / ATCC 27343 / NCTC 10154.
  2. "Exploring the Mycoplasma capricolum genome: a minimal cell reveals its physiology."
    Bork P., Ouzounis C., Casari G., Schneider R., Sander C., Dolan M., Gilbert W., Gillevet P.M.
    Mol. Microbiol. 16:955-967(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-182.

Entry informationi

Entry nameiGPMI_MYCCT
AccessioniPrimary (citable) accession number: Q49006
Secondary accession number(s): Q2SRB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2003
Last sequence update: March 20, 2006
Last modified: March 31, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.