Q49006 (GPMI_MYCCT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=iPGM
EC=5.4.2.1

Gene names

Name:	gpmI
Ordered Locus Names:	MCAP_0752

Organism

Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) [Complete proteome] [HAMAP]

Taxonomic identifier

340047 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma mycoides group › Mycoplasma capricolum › Mycoplasma capricolum subsp. capricolum

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP-Rule MF_01038
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP-Rule MF_01038
Cofactor	Binds 2 manganese ions per subunit By similarity.
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP-Rule MF_01038
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 531	531	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP-Rule MF_01038		PRO_0000212165
Sites
	Active site	63	1	Phosphoserine intermediate By similarity
	Metal binding	13	1	Manganese 2 By similarity
	Metal binding	63	1	Manganese 2 By similarity
	Metal binding	420	1	Manganese 1 By similarity
	Metal binding	424	1	Manganese 1 By similarity
	Metal binding	462	1	Manganese 2 By similarity
	Metal binding	463	1	Manganese 2 By similarity
	Metal binding	480	1	Manganese 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q49006 [UniParc]. Last modified March 21, 2006. Version 2. Checksum: 4AC56842D6F37724	FASTA	531	60,036
	10 20 30 40 50 60 MKVKRPILLA ILDGWGLAEP DKGNAVDNAN MIFVKQLKQT YPWLKAHASG KWVGLPENQM 70 80 90 100 110 120 GNSEVGHIHL GAGRINLESL AKLNHETKTN NIAKNDEIVK TFEYVKKNNS ALHLMGLFSN 130 140 150 160 170 180 GGVHSHFDHM IAIYKAAIVY GITNIKFDLI TDGRDTKPKL AYDFIKNLLE LIKQNNNIGI 190 200 210 220 230 240 ISSVSGRYYA MDRDKRFDRS RIAYNAIVNR NNVRSFTNIL DYIQQEYMIN HDDEMIIPAF 250 260 270 280 290 300 NQDDFNGNLK ANDAIIMTNF RPDRAIQISS ILTNKNYIAW QSEAFSDAEF IGDKIRFVSM 310 320 330 340 350 360 MKYSDSVTSP HIAYPPKPLT NTLGQYLSKL GLKQLRIAET EKIAHVTFFF DGGNDYFKNG 370 380 390 400 410 420 LAKNDEITLA NAYIDLIPSA KVATYDLKPQ MSAVEITDKL LEEIKKDEFD FIVLNFANCD 430 440 450 460 470 480 MVGHTGNNKA TEIACKTLDD QLKRIHDEFV LKHNGIMVIT ADHGNAEIMI DKDDQVNKKH 490 500 510 520 530 TTSLVPIIIT DKNIKLKQND PAIAKVAPTI LDLMNIEIPK EMELESMIDH N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Glass J.I., Lartigue C., Pfannkoch C., Baden-Tillson H., Smith H.O., Venter J.C., Roske K., Wise K.S., Calcutt M.J., Nelson W.C., Nierman W.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: California kid / ATCC 27343 / NCTC 10154.
[2]	"Exploring the Mycoplasma capricolum genome: a minimal cell reveals its physiology." Bork P., Ouzounis C., Casari G., Schneider R., Sander C., Dolan M., Gilbert W., Gillevet P.M. Mol. Microbiol. 16:955-967(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-182.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000123 Genomic DNA. Translation: ABC01874.1. Z33087 Genomic DNA. Translation: CAA83752.1.
PIR	S77784.
RefSeq	YP_424703.1. NC_007633.1.
3D structure databases
ProteinModelPortal	Q49006.
ModBase	Search...
Protein-protein interaction databases
STRING	340047.MCAP_0752.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABC01874; ABC01874; MCAP_0752.
GeneID	3828629.
KEGG	mcp:MCAP_0752.
PATRIC	20005983. VBIMycCap130493_0733.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0696.
HOGENOM	HOG000223664.
KO	K15633.
OMA	NAEQMTD.
ProtClustDB	PRK05434.
Enzyme and pathway databases
UniPathway	UPA00109; UER00186.
Family and domain databases
Gene3D	3.40.1450.10. 1 hit. 3.40.720.10. 2 hits.
HAMAP	MF_01038. GpmI.
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR011258. BPG-indep_PGM_N. IPR006124. Metalloenzyme. IPR005995. Pgm_bpd_ind. [Graphical view]
Pfam	PF06415. iPGM_N. 1 hit. PF01676. Metalloenzyme. 1 hit. [Graphical view]
PIRSF	PIRSF001492. IPGAM. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit. SSF64158. BPG-indep_PGM_N. 1 hit.
TIGRFAMs	TIGR01307. pgm_bpd_ind. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GPMI_MYCCT

Accession

Primary (citable) accession number: Q49006
Secondary accession number(s): Q2SRB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program