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Q49006 (GPMI_MYCCT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=iPGM
EC=5.4.2.12
Gene names
Name:gpmI
Ordered Locus Names:MCAP_0752
OrganismMycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) [Complete proteome] [HAMAP]
Taxonomic identifier340047 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP-Rule MF_01038

Catalytic activity

2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP-Rule MF_01038

Cofactor

Binds 2 manganese ions per subunit By similarity. HAMAP-Rule MF_01038

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP-Rule MF_01038

Subunit structure

Monomer By similarity. HAMAP-Rule MF_01038

Sequence similarities

Belongs to the BPG-independent phosphoglycerate mutase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandManganese
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglucose catabolic process

Inferred from electronic annotation. Source: InterPro

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_function2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

manganese ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5315312,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP-Rule MF_01038
PRO_0000212165

Sites

Active site631Phosphoserine intermediate By similarity
Metal binding131Manganese 2 By similarity
Metal binding631Manganese 2 By similarity
Metal binding4201Manganese 1 By similarity
Metal binding4241Manganese 1 By similarity
Metal binding4621Manganese 2 By similarity
Metal binding4631Manganese 2 By similarity
Metal binding4801Manganese 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q49006 [UniParc].

Last modified March 21, 2006. Version 2.
Checksum: 4AC56842D6F37724

FASTA53160,036
        10         20         30         40         50         60 
MKVKRPILLA ILDGWGLAEP DKGNAVDNAN MIFVKQLKQT YPWLKAHASG KWVGLPENQM 

        70         80         90        100        110        120 
GNSEVGHIHL GAGRINLESL AKLNHETKTN NIAKNDEIVK TFEYVKKNNS ALHLMGLFSN 

       130        140        150        160        170        180 
GGVHSHFDHM IAIYKAAIVY GITNIKFDLI TDGRDTKPKL AYDFIKNLLE LIKQNNNIGI 

       190        200        210        220        230        240 
ISSVSGRYYA MDRDKRFDRS RIAYNAIVNR NNVRSFTNIL DYIQQEYMIN HDDEMIIPAF 

       250        260        270        280        290        300 
NQDDFNGNLK ANDAIIMTNF RPDRAIQISS ILTNKNYIAW QSEAFSDAEF IGDKIRFVSM 

       310        320        330        340        350        360 
MKYSDSVTSP HIAYPPKPLT NTLGQYLSKL GLKQLRIAET EKIAHVTFFF DGGNDYFKNG 

       370        380        390        400        410        420 
LAKNDEITLA NAYIDLIPSA KVATYDLKPQ MSAVEITDKL LEEIKKDEFD FIVLNFANCD 

       430        440        450        460        470        480 
MVGHTGNNKA TEIACKTLDD QLKRIHDEFV LKHNGIMVIT ADHGNAEIMI DKDDQVNKKH 

       490        500        510        520        530 
TTSLVPIIIT DKNIKLKQND PAIAKVAPTI LDLMNIEIPK EMELESMIDH N 

« Hide

References

« Hide 'large scale' references
[1]Glass J.I., Lartigue C., Pfannkoch C., Baden-Tillson H., Smith H.O., Venter J.C., Roske K., Wise K.S., Calcutt M.J., Nelson W.C., Nierman W.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: California kid / ATCC 27343 / NCTC 10154.
[2]"Exploring the Mycoplasma capricolum genome: a minimal cell reveals its physiology."
Bork P., Ouzounis C., Casari G., Schneider R., Sander C., Dolan M., Gilbert W., Gillevet P.M.
Mol. Microbiol. 16:955-967(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-182.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000123 Genomic DNA. Translation: ABC01874.1.
Z33087 Genomic DNA. Translation: CAA83752.1.
PIRS77784.
RefSeqYP_424703.1. NC_007633.1.

3D structure databases

ProteinModelPortalQ49006.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340047.MCAP_0752.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC01874; ABC01874; MCAP_0752.
GeneID3828629.
KEGGmcp:MCAP_0752.
PATRIC20005983. VBIMycCap130493_0733.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0696.
HOGENOMHOG000223664.
KOK15633.
OMAEFFIPAI.
OrthoDBEOG6HJ22X.

Enzyme and pathway databases

BioCycMCAP340047:GC0H-749-MONOMER.
UniPathwayUPA00109; UER00186.

Family and domain databases

Gene3D3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPMF_01038. GpmI.
InterProIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFPIRSF001492. IPGAM. 1 hit.
SUPFAMSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsTIGR01307. pgm_bpd_ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGPMI_MYCCT
AccessionPrimary (citable) accession number: Q49006
Secondary accession number(s): Q2SRB0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 21, 2006
Last modified: June 11, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways