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Protein
Submitted name:

Beta-galactosidase

Gene

lacZ

Organism
Streptococcus pyogenes serotype M1
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseSAAS annotationImported, Hydrolase

Enzyme and pathway databases

BioCyciSPYO293653:GHFC-1364-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-galactosidaseImported (EC:3.2.1.23Imported)
Gene namesi
Name:lacZImported
Ordered Locus Names:M5005_Spy1304Imported
OrganismiStreptococcus pyogenes serotype M1Imported
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002702: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi293653.M5005_Spy_1304.

Structurei

3D structure databases

ProteinModelPortaliQ48XK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK01190.
OrthoDBiEOG680WZ9.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SUPFAMiSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48XK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPDSKEQTV TGYQYHYIDQ EGRKQPFNQG WRFLMADVAC AQDPSFDDSN
60 70 80 90 100
WQVIHLPHDF SLTQPYTRNG EAESAYKLGG VGWYRHYLVL DEVLAGCHVA
110 120 130 140 150
ITFEGSYMET EIYVNGQFIG KHLNGYQEFT YDISDVVTFG AENLLAVRVE
160 170 180 190 200
NKVPSSRWYS GSGLYREVSL SVLPQLHFVA DQVAMTLADT AVQEKGQQKV
210 220 230 240 250
DLRFALNQSI QTCHYQLSLC LWEQSHCSKD KKLLYQETEV PLADLAFQRQ
260 270 280 290 300
YGLTLSLEEL QLWSPDNPHL YDLELTLYYQ GQVIDCFCLE TGFRQLTFMA
310 320 330 340 350
NQGLFVNGRA VKLKGVCLHH DQGGLGACAY EDALARQLVL LKDMGANTIR
360 370 380 390 400
STHNPSSPKL RQLANRLGFF VIEEAFDTWT YAKNGNVNDF SNYFHQTIGT
410 420 430 440 450
ENANYLQRVR SPETSWAQYS IEAMVWSAKN DPSVLMWSIG NELMEGFSAD
460 470 480 490 500
VSHYPELTRQ MCQWITAIDT SRPITFGDNK LKEADFCWHE EVSQMATLLS
510 520 530 540 550
QLDHPQGLIG LNYADGKDYD RLHEEHSDWL LYGSETVSAI TSRAYYKETK
560 570 580 590 600
KVLDSGYHLT SYDHAKVDWG AFASQAWYDT ITRDFVAGEC VWTGFDYLGE
610 620 630 640 650
PTPWNKIDSG VVGLWPSPKN AYFGILDTAG FPKDSYYFYQ SQWAQGQTTL
660 670 680 690 700
HLLPVWQKDQ LCFDEQGLVE VVVYSNAASV QLMFEDEQGN LTDYGRKAFH
710 720 730 740 750
TYSTPTGHTY QLYQGADAAK NPHENLYLTW RVPYQKGLLR AVAYDISGKS
760 770 780 790 800
IPKTSGRSQV RTYGSVAKLS WKAFEAPIDA PWELLYLDLS LLDSRGELVS
810 820 830 840 850
HAQDWLQVQV EGPARLLALD NGNPTDHTPY QEPLRQAYGG KLLAILALTG
860 870 880 890 900
EAGHIKVTAK ASQQLSSVFQ TQVACRAPKE HLVTLPLEKY QFKKSRLTSQ
910 920 930 940 950
QEIGQSCLKT TQFLSVLENK DTQQKAGKAS TPHILITSYQ HYLSLPLQVC
960 970 980 990 1000
SQAFDFKKGD DIFLPQWLQV KDAQGSLVKK AFSMTWYLKE KIFAKPILVT
1010 1020 1030 1040 1050
GYVSCFGQSI PVEARLNLAQ ASKRRHQDLS LVAKQSLAAS QKRLTYCYQY
1060 1070 1080 1090 1100
DTVQAIGAIS LQNHTGTSLS VSVAISYGSQ SSIKQETLML ADSHLSQLEE
1110 1120 1130
VIFFDDILTV LYLAVTLEVI EGPDLTEDSI QIGLWDLA
Length:1,138
Mass (Da):128,498
Last modified:September 13, 2005 - v1
Checksum:i91267821EA5A0D51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000017 Genomic DNA. Translation: AAZ51922.1.
RefSeqiYP_282667.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAZ51922; AAZ51922; M5005_Spy1304.
GeneIDi3571618.
KEGGispz:M5005_Spy_1304.
PATRICi19741399. VBIStrPyo7871_1347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000017 Genomic DNA. Translation: AAZ51922.1.
RefSeqiYP_282667.1. NC_007297.1.

3D structure databases

ProteinModelPortaliQ48XK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi293653.M5005_Spy_1304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ51922; AAZ51922; M5005_Spy1304.
GeneIDi3571618.
KEGGispz:M5005_Spy_1304.
PATRICi19741399. VBIStrPyo7871_1347.

Phylogenomic databases

KOiK01190.
OrthoDBiEOG680WZ9.

Enzyme and pathway databases

BioCyciSPYO293653:GHFC-1364-MONOMER.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SUPFAMiSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1Imported.

Entry informationi

Entry nameiQ48XK3_STRP1
AccessioniPrimary (citable) accession number: Q48XK3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: January 7, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.