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Q48VX3

- PUR5_STRPM

UniProt

Q48VX3 - PUR5_STRPM

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Streptococcus pyogenes serotype M28 (strain MGAS6180)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPYO319701:GHAD-57-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:M28_Spy0025
    OrganismiStreptococcus pyogenes serotype M28 (strain MGAS6180)
    Taxonomic identifieri319701 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000009292: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258416Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi319701.M28_Spy0025.

    Structurei

    3D structure databases

    ProteinModelPortaliQ48VX3.
    SMRiQ48VX3. Positions 15-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiPDMYGAD.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q48VX3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEKNAYAKS GVDVEAGYEV VERIKKHVAR TERAGVMGAL GGFGGMFDLS    50
    KTGVREPVLV SGTDGVGTKL MLAIKYDKHD TIGQDCVAMC VNDIIAAGAE 100
    PLYFLDYVAT GKNNPVKFEE VVSGVAEGCV QAGAALIGGE TAEMPGMYGE 150
    DDYDLAGFAV GVAEKSQLID GSKVKEGDIL LGLASSGIHS NGYSLVRRVF 200
    ADYTGKELLP ELEGKQLKDV LLEPTRIYVR AALPLIKEEL INGIGHITGG 250
    GFIENVPRMF ADDLAAEIDE DKVPVLPIFK ALEKYGDIKH EEMFEIFNMG 300
    VGLMLAVSPE NVNRVKELLD EPVYEIGRII KKADDSVVIK 340
    Length:340
    Mass (Da):36,578
    Last modified:September 13, 2005 - v1
    Checksum:iC4E8E2AB6557EE96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000056 Genomic DNA. Translation: AAX71139.1.
    RefSeqiYP_279494.1. NC_007296.1.

    Genome annotation databases

    EnsemblBacteriaiAAX71139; AAX71139; M28_Spy0025.
    GeneIDi3573094.
    KEGGispb:M28_Spy0025.
    PATRICi19742738. VBIStrPyo35950_0026.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000056 Genomic DNA. Translation: AAX71139.1 .
    RefSeqi YP_279494.1. NC_007296.1.

    3D structure databases

    ProteinModelPortali Q48VX3.
    SMRi Q48VX3. Positions 15-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 319701.M28_Spy0025.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX71139 ; AAX71139 ; M28_Spy0025 .
    GeneIDi 3573094.
    KEGGi spb:M28_Spy0025.
    PATRICi 19742738. VBIStrPyo35950_0026.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi PDMYGAD.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci SPYO319701:GHAD-57-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity."
      Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M.
      J. Infect. Dis. 192:760-770(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS6180.

    Entry informationi

    Entry nameiPUR5_STRPM
    AccessioniPrimary (citable) accession number: Q48VX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3