Q48VA9 (UPPP_STRPM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA
Ordered Locus Names:	M28_Spy0233

Organism

Streptococcus pyogenes serotype M28 (strain MGAS6180) [Complete proteome] [HAMAP]

Taxonomic identifier

319701 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes › Streptococcus pyogenes serotype M28

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000227643
Regions
	Transmembrane	2 – 22	21	Helical; Potential
	Transmembrane	44 – 64	21	Helical; Potential
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	113 – 133	21	Helical; Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Transmembrane	188 – 208	21	Helical; Potential
	Transmembrane	223 – 243	21	Helical; Potential
	Transmembrane	255 – 275	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q48VA9 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: AB0EC20DBD1B8A30	FASTA	279	31,538
	10 20 30 40 50 60 MLIIELLKAI FFGIIEGITE WLPVSSTGHL ILVQEFIRLN QDKAFIEMFN IVIQLGAIIA 70 80 90 100 110 120 VMLIYFERLN PFQPGKTARE VQLTWQLWLK VVIACIPSIL IAVPLDNWFE AHFYFMVPIA 130 140 150 160 170 180 IALIVYGIAF IWIEKRNAQQ EPAVTELARM SYKTAFFIGC FQVLSIVPGT SRSGATILGA 190 200 210 220 230 240 IILGTSRTVA ADFTFFLAIP TMFGYSGLKA VKFFLDGHHL DFAQVLILLV ASLTAFVVSL 250 260 270 LAIRFLTDYV KKHDFTIFGK YRIVLGSLLL IYSFFKFVF

References

[1]

"Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity." Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M. J. Infect. Dis. 192:760-770(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS6180.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000056 Genomic DNA. Translation: AAX71347.1.
RefSeq	YP_279702.1. NC_007296.1.
3D structure databases
ProteinModelPortal	Q48VA9.
ModBase	Search...
Protein-protein interaction databases
STRING	319701.M28_Spy0233.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX71347; AAX71347; M28_Spy0233.
GeneID	3574625.
KEGG	spb:M28_Spy0233.
PATRIC	19743200. VBIStrPyo35950_0241.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	NDWLDKH.
ProtClustDB	PRK00281.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_STRPM

Accession

Primary (citable) accession number: Q48VA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	September 13, 2005
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program