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Q48VA9

- UPPP_STRPM

UniProt

Q48VA9 - UPPP_STRPM

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, bacA, M28_Spy0233
Organism
Streptococcus pyogenes serotype M28 (strain MGAS6180)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSPYO319701:GHAD-280-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA
Ordered Locus Names:M28_Spy0233
OrganismiStreptococcus pyogenes serotype M28 (strain MGAS6180)
Taxonomic identifieri319701 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000009292: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Reviewed prediction
Add
BLAST
Transmembranei44 – 6421Helical; Reviewed prediction
Add
BLAST
Transmembranei85 – 10521Helical; Reviewed prediction
Add
BLAST
Transmembranei113 – 13321Helical; Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Transmembranei188 – 20821Helical; Reviewed prediction
Add
BLAST
Transmembranei223 – 24321Helical; Reviewed prediction
Add
BLAST
Transmembranei255 – 27521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Undecaprenyl-diphosphataseUniRule annotation
PRO_0000227643Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi319701.M28_Spy0233.

Structurei

3D structure databases

ProteinModelPortaliQ48VA9.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiMILVEEF.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q48VA9-1 [UniParc]FASTAAdd to Basket

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MLIIELLKAI FFGIIEGITE WLPVSSTGHL ILVQEFIRLN QDKAFIEMFN    50
IVIQLGAIIA VMLIYFERLN PFQPGKTARE VQLTWQLWLK VVIACIPSIL 100
IAVPLDNWFE AHFYFMVPIA IALIVYGIAF IWIEKRNAQQ EPAVTELARM 150
SYKTAFFIGC FQVLSIVPGT SRSGATILGA IILGTSRTVA ADFTFFLAIP 200
TMFGYSGLKA VKFFLDGHHL DFAQVLILLV ASLTAFVVSL LAIRFLTDYV 250
KKHDFTIFGK YRIVLGSLLL IYSFFKFVF 279
Length:279
Mass (Da):31,538
Last modified:September 13, 2005 - v1
Checksum:iAB0EC20DBD1B8A30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000056 Genomic DNA. Translation: AAX71347.1.
RefSeqiYP_279702.1. NC_007296.1.

Genome annotation databases

EnsemblBacteriaiAAX71347; AAX71347; M28_Spy0233.
GeneIDi3574625.
KEGGispb:M28_Spy0233.
PATRICi19743200. VBIStrPyo35950_0241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000056 Genomic DNA. Translation: AAX71347.1 .
RefSeqi YP_279702.1. NC_007296.1.

3D structure databases

ProteinModelPortali Q48VA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319701.M28_Spy0233.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX71347 ; AAX71347 ; M28_Spy0233 .
GeneIDi 3574625.
KEGGi spb:M28_Spy0233.
PATRICi 19743200. VBIStrPyo35950_0241.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi MILVEEF.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci SPYO319701:GHAD-280-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity."
    Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M.
    J. Infect. Dis. 192:760-770(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS6180.

Entry informationi

Entry nameiUPPP_STRPM
AccessioniPrimary (citable) accession number: Q48VA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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