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Q48UK8

- Q48UK8_STRPM

UniProt

Q48UK8 - Q48UK8_STRPM

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppc, M28_Spy0484
Organism
Streptococcus pyogenes serotype M28 (strain MGAS6180)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei155 – 1551 By similarityUniRule annotation
Active sitei600 – 6001 By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, PyruvateImported

Enzyme and pathway databases

BioCyciSPYO319701:GHAD-537-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:M28_Spy0484Imported
OrganismiStreptococcus pyogenes serotype M28 (strain MGAS6180)Imported
Taxonomic identifieri319701 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000009292: Chromosome

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi319701.M28_Spy0484.

Structurei

3D structure databases

ProteinModelPortaliQ48UK8.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.
OMAiIDIVAQK.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q48UK8-1 [UniParc]FASTAAdd to Basket

« Hide

MVKSGMIEET SKEGDGHLPL KKLESSNNQA IIAEEVALLK EMLENITRRM    50
IGDDAFAVIE SIMVLSEKQD YIELEKVVAN ISNQEMEVIS RYFSILPLLI 100
NISEDVDLAY EINYQNNTDT DYLGKLALTI KDLAGKDNGK DILEQVNVVP 150
VLTAHPTQVQ RKTILELTTH IHKLLRKYRD AKAGVINLEK WRQELYRYIE 200
MIMQTDIIRE KKLQVKNEIK NVMQYYDGSL IQAVTKLTTE YKNLAQKHGL 250
ELDNPKPITM GMWIGGDRDG NPFVTAETLC LSATVQSEVI LNYYIDKLAA 300
LYRTFSLSST LVQPNSEVER LASLSQDQSI YRGNEPYRRA FHYIQSRLKQ 350
TQIQLTNQPA ARMSSSVGLS TSAWSSPASL ENPILAYDSP VDFKADLKAI 400
EQSLLDNGNS ALIEGDLREV MQAVDIFGFF LASIDMRQDS SVQESCVAEL 450
LKGANIVDDY SSLSETEKCD VLLQQLMEEP RTLSSAAVAK SDLLEKELAI 500
YTTARELKDK LGEEVIKQHI ISHTESVSDM FELAIMLKEV GLVDQQRARV 550
QIVPLFETIE DLDNARDIMA AYLSHDIVKS WIATNRNYQE IMLGYSDSNK 600
DGGYLASGWT LYKAQNELTA IGEEHGVKIT FFHGRGGTVG RGGGPSYDAI 650
TSQPFGSIKD RIRLTEQGEI IENKYGNKDV AYYHLEMLIS ASINRMVTQM 700
ITDPNEIDSF REIMDSIVAD SNTIYRKLVF DNPHFYDYFF EASPIKEVSS 750
LNIGSRPAAR KTITEITGLR AIPWVFSWSQ NRIMFPGWYG VGSAFKRYID 800
RAQGNLERLQ HMYQTWPFFH SLLSNVDMVL SKSNMNIAFQ YAQLAESQDV 850
RDVFYEILDE WQLTKNVILA IQDHDDLLED NPSLKHSLKS RLPYFNVLNY 900
IQIELIKRWR NNQLDENDEK LIHTTINGIA TGLRNSG 937
Length:937
Mass (Da):106,453
Last modified:September 13, 2005 - v1
Checksum:i94965DC4CE9B7E00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000056 Genomic DNA. Translation: AAX71598.1.
RefSeqiWP_011284622.1. NC_007296.1.
YP_279953.1. NC_007296.1.

Genome annotation databases

EnsemblBacteriaiAAX71598; AAX71598; M28_Spy0484.
GeneIDi3573357.
KEGGispb:M28_Spy0484.
PATRICi19743736. VBIStrPyo35950_0503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000056 Genomic DNA. Translation: AAX71598.1 .
RefSeqi WP_011284622.1. NC_007296.1.
YP_279953.1. NC_007296.1.

3D structure databases

ProteinModelPortali Q48UK8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 319701.M28_Spy0484.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX71598 ; AAX71598 ; M28_Spy0484 .
GeneIDi 3573357.
KEGGi spb:M28_Spy0484.
PATRICi 19743736. VBIStrPyo35950_0503.

Phylogenomic databases

HOGENOMi HOG000238647.
KOi K01595.
OMAi IDIVAQK.
OrthoDBi EOG6TJ7T8.

Enzyme and pathway databases

BioCyci SPYO319701:GHAD-537-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity."
    Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., LeFebvre R.B., Musser J.M.
    J. Infect. Dis. 192:760-770(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS6180Imported.

Entry informationi

Entry nameiQ48UK8_STRPM
AccessioniPrimary (citable) accession number: Q48UK8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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