ID   MURA1_STRPM             Reviewed;         423 AA.
AC   Q48UD0;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1;
DE            EC=2.5.1.7;
DE   AltName: Full=Enoylpyruvate transferase 1;
DE   AltName: Full=UDP-N-acetylglucosamine enolpyruvyl transferase 1;
DE            Short=EPT 1;
GN   Name=murA1; Synonyms=murA; OrderedLocusNames=M28_Spy0562;
OS   Streptococcus pyogenes serotype M28.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=319700;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS6180 / Serotype M28;
RX   PubMed=16088825; DOI=10.1086/430618;
RA   Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D.,
RA   Beres S.B., Lefebvre R.B., Musser J.M.;
RT   "Genome sequence of a serotype M28 strain of group A Streptococcus:
RT   potential new insights into puerperal sepsis and bacterial disease
RT   specificity.";
RL   J. Infect. Dis. 192:760-770(2005).
CC   -!- FUNCTION: Cell wall formation. Adds enolpyruvyl to UDP-N-
CC       acetylglucosamine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Phosphoenolpyruvate + UDP-N-acetyl-D-
CC       glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-
CC       glucosamine.
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the EPSP synthase family. MurA subfamily.
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DR   EMBL; CP000056; AAX71676.1; -; Genomic_DNA.
DR   RefSeq; YP_280031.1; -.
DR   GeneID; 3574772; -.
DR   GenomeReviews; CP000056_GR; M28_Spy0562.
DR   KEGG; spb:M28_Spy0562; -.
DR   HOGENOM; Q48UD0; -.
DR   OMA; Q48UD0; VSRVYHL.
DR   BioCyc; SPYO319701:M28_SPY0562-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008760; F:UDP-N-acetylglucosamine 1-carboxyvinyltrans...; IEA:HAMAP.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007047; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   GO; GO:0019277; P:UDP-N-acetylgalactosamine biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00111; -; 1.
DR   InterPro; IPR001986; EPSP_synthase_core.
DR   InterPro; IPR005750; UDP_GlcNAc_COvinyl_MurA.
DR   Gene3D; G3DSA:3.65.10.10; EPSP_synthase; 1.
DR   PANTHER; PTHR21090:SF4; AcGlu_Tran_MurA; 1.
DR   Pfam; PF00275; EPSP_synthase; 1.
DR   ProDom; PD001867; EPSP_synth; 1.
DR   TIGRFAMs; TIGR01072; murA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell shape;
KW   Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;
KW   Peptidoglycan synthesis; Transferase.
FT   CHAIN         1    423       UDP-N-acetylglucosamine 1-
FT                                carboxyvinyltransferase 1.
FT                                /FTId=PRO_0000231280.
FT   ACT_SITE    120    120       Proton donor (By similarity).
FT   BINDING     120    120       Phosphoenolpyruvate (covalent) (By
FT                                similarity).
SQ   SEQUENCE   423 AA;  45601 MW;  C4A1C687D74BB9D9 CRC64;
     MDKIIIEGGQ TRLEGEVVIE GAKNAVLPLL AASILPSKGK TILRNVPILS DVFTMNNVVR
     GLDIRVDFNE AANEITVDAS GHILDEAPYE YVSQMRASIV VLGPILARNG HAKVSMPGGC
     TIGSRPINLH LKGLEAMGAT ITQKGGDITA QADRLQGAMI YMDFPSVGAT QNLMMAATLA
     DGVTTIENAA REPEIVDLAQ FLNKMGARIR GAGTETLTIT GVTSLHGVEH DVVQDRIEAG
     TFMVAAAMTS GNVLIRDAVW EHNRPLISKL MEMGVSVTEE EYGIRVQANT PKLKPVTVKT
     LPHPGFPTDM QAQFTALMAV VNGESTMVET VFENRFQHLE EMRRMGLQSE ILRETAMIHG
     GRQLQGAPVM STDLRASAAL ILTGIVAQGV TIVNNLVHLD RGYYQFHEKL AKLGATISRS
     SEV
//