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Protein

Lantibiotic

Gene

srtA

Organism
Streptococcus pyogenes serotype M28 (strain MGAS6180)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Bacteriocin, LantibioticUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
LantibioticUniRule annotation
Gene namesi
Name:srtAImported
Ordered Locus Names:M28_Spy0781Imported
OrganismiStreptococcus pyogenes serotype M28 (strain MGAS6180)Imported
Taxonomic identifieri319701 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000009292 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Post-translational modificationi

Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.UniRule annotation

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ48TR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type A lantibiotic family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000124438

Family and domain databases

InterProiView protein in InterPro
IPR006079 Lantibiotic_typ-A_Bacillales
TIGRFAMsiTIGR03731 lantibio_gallid, 1 hit

Sequencei

Sequence statusi: Complete.

Q48TR2-1 [UniParc]FASTAAdd to basket

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        10         20         30         40 
MNNTIKDFDL DLKTNKKDTA TPYVGSRYLC TPGSCWKLVC FTTTVK
Length:46
Mass (Da):5,219
Last modified:September 13, 2005 - v1
Checksum:i3775CC54B8A2B00F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000056 Genomic DNA Translation: AAX71894.1
RefSeqiWP_002984803.1, NC_007296.1

Genome annotation databases

EnsemblBacteriaiAAX71894; AAX71894; M28_Spy0781
KEGGispb:M28_Spy0781

Similar proteinsi

Entry informationi

Entry nameiQ48TR2_STRPM
AccessioniPrimary (citable) accession number: Q48TR2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health