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Q48TM3 (NADK_STRPM) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:M28_Spy0824
OrganismStreptococcus pyogenes serotype M28 (strain MGAS6180) [Complete proteome] [HAMAP]
Taxonomic identifier319701 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279NAD kinase HAMAP-Rule MF_00361
PRO_0000229695

Regions

Nucleotide binding57 – 582NAD By similarity
Nucleotide binding133 – 1342NAD By similarity
Nucleotide binding172 – 1776NAD By similarity

Sites

Active site571Proton acceptor By similarity
Binding site1591NAD By similarity
Binding site1611NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q48TM3 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: EAC0EA8ECB3D57A9

FASTA27931,506
        10         20         30         40         50         60 
MMTQMNYTGK VKRVAIIANG KYQSKRVASK LFSVFKDDPD FYLSKKNPDI VISIGGDGML 

        70         80         90        100        110        120 
LSAFHMYEKE LDKVRFVGIH TGHLGFYTDY RDFEVDKLID NLRKDKGEQI SYPILKVAIT 

       130        140        150        160        170        180 
LDDGRVVKAR ALNEATVKRI EKTMVADVII NHVKFESFRG DGISVSTPTG STAYNKSLGG 

       190        200        210        220        230        240 
AVLHPTIEAL QLTEISSLNN RVFRTLGSSI IIPKKDKIEL VPKRLGIYTI SIDNKTYQLK 

       250        260        270 
NVTKVEYFID DEKIHFVSSP SHTSFWKRVK DAFIGEIDS 

« Hide

References

[1]"Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity."
Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M.
J. Infect. Dis. 192:760-770(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGAS6180.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000056 Genomic DNA. Translation: AAX71937.1.
RefSeqYP_280292.1. NC_007296.1.

3D structure databases

ProteinModelPortalQ48TM3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING319701.M28_Spy0824.

Proteomic databases

PRIDEQ48TM3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX71937; AAX71937; M28_Spy0824.
GeneID3574899.
KEGGspb:M28_Spy0824.
PATRIC19744429. VBIStrPyo35950_0845.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000275803.
KOK00858.
OMAWRADELE.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycSPYO319701:GHAD-880-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_STRPM
AccessionPrimary (citable) accession number: Q48TM3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families