Q48TL1 (KITH_STRPM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	tdk
Ordered Locus Names:	M28_Spy0836

Organism

Streptococcus pyogenes serotype M28 (strain MGAS6180) [Complete proteome] [HAMAP]

Taxonomic identifier

319701 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes › Streptococcus pyogenes serotype M28

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00124.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Thymidine kinase HAMAP-Rule MF_00124		PRO_0000242811
Regions
	Nucleotide binding	9 – 16	8	ATP By similarity
	Nucleotide binding	85 – 88	4	ATP By similarity
Sites
	Active site	86	1	Proton acceptor Potential
	Metal binding	143	1	Zinc By similarity
	Metal binding	146	1	Zinc By similarity
	Metal binding	180	1	Zinc By similarity
	Metal binding	183	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q48TL1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: BF895E3F609B821E	FASTA	189	21,547
	10 20 30 40 50 60 MAQLYYKYGT MNSGKTIEIL KVAHNYEEQG KPVVIMTSAL DTRDGFGIVS SRIGMRREAI 70 80 90 100 110 120 PISNDMDIFT FIAQLEEKPY CVLIDESQFL SKQNVYDLAR VVDELNVPVM AFGLKNDFQN 130 140 150 160 170 180 NLFEGSKHLL LLADKIDEIK TICQYCSKKA TMVLRTENGK PVYEGDQIQI GGNETYIPVC RKHYFNPEI

References

[1]

"Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity." Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M. J. Infect. Dis. 192:760-770(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS6180.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000056 Genomic DNA. Translation: AAX71949.1.
RefSeq	YP_280304.1. NC_007296.1.
3D structure databases
ProteinModelPortal	Q48TL1.
ModBase	Search...
Protein-protein interaction databases
STRING	319701.M28_Spy0836.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX71949; AAX71949; M28_Spy0836.
GeneID	3573566.
KEGG	spb:M28_Spy0836.
PATRIC	19744453. VBIStrPyo35950_0857.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1435.
HOGENOM	HOG000076391.
KO	K00857.
OMA	FRYGAMN.
ProtClustDB	PRK04296.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase.
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_STRPM

Accession

Primary (citable) accession number: Q48TL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	September 13, 2005
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program