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Protein

Formate--tetrahydrofolate ligase 1

Gene

fhs1

Organism
Streptococcus pyogenes serotype M28 (strain MGAS6180)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 1UniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetase 1UniRule annotation
Short name:
FHS 1UniRule annotation
Short name:
FTHFS 1UniRule annotation
Gene namesi
Name:fhs1UniRule annotation
Synonyms:fhs.1
Ordered Locus Names:M28_Spy0899
OrganismiStreptococcus pyogenes serotype M28 (strain MGAS6180)
Taxonomic identifieri319701 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000009292 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001993931 – 556Formate--tetrahydrofolate ligase 1Add BLAST556

Structurei

3D structure databases

ProteinModelPortaliQ48TE8.
SMRiQ48TE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiView protein in InterPro
IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01268. FTHFS. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48TE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSDIEIAQS VALQPITDIV KKVGIDGDDI ELYGKYKAKL SFEKMKAVEA
60 70 80 90 100
NEPGKLLLVT AINPTPAGEG KSTMSIGLAD ALNQMGKKTM LALREPSLGP
110 120 130 140 150
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALIDNHLQQ
160 170 180 190 200
GNDLGIDPRR IIWKRVLDLN DRALRQVIVG LGSPVNGVPR EDGFDITVAS
210 220 230 240 250
EIMAILCLAT DLKDLKKRLA DIVVAYTYDR KPVYVRDLKV EGALTLILKD
260 270 280 290 300
AIKPNLVQTI YGTPALIHGG PFANIAHGCN SVLATSTALR LADYTVTEAG
310 320 330 340 350
FGADLGAEKF LNIKVPNLPK APDAIVIVAT LRALKMHGGV AKSDLAAENC
360 370 380 390 400
EAVRLGFANL KRHVENMRQF KVPVVVAINE FVADTEAEIA TLKALCEEIK
410 420 430 440 450
VPVELASVWA NGAEGGLALA KTVVRVIDQE AADYKRLYSD EDTLEEKVIN
460 470 480 490 500
IVTQIYGGKA VQFGPKAKTQ LKQFTEFGWD KLPVCMAKTQ YSFSDNPSLL
510 520 530 540 550
GAPTDFDITI REFVPKTGAG FIVGLTGDVM TMPGLPKVPA AMAMDVAENG

TALGLF
Length:556
Mass (Da):59,561
Last modified:September 13, 2005 - v1
Checksum:iC0DDCB8248E7E957
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000056 Genomic DNA. Translation: AAX72012.1.
RefSeqiWP_011284813.1. NC_007296.1.

Genome annotation databases

EnsemblBacteriaiAAX72012; AAX72012; M28_Spy0899.
KEGGispb:M28_Spy0899.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFTHS1_STRPM
AccessioniPrimary (citable) accession number: Q48TE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 13, 2005
Last modified: July 5, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families