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Protein

Superoxide dismutase

Gene

sodA

Organism
Streptococcus pyogenes serotype M28 (strain MGAS6180)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: InterPro
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Enzyme and pathway databases

BioCyciSPYO319701:GHAD-1192-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sodAImported
Ordered Locus Names:M28_Spy1139Imported
OrganismiStreptococcus pyogenes serotype M28 (strain MGAS6180)Imported
Taxonomic identifieri319701 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000009292 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi319701.M28_Spy1139.

Structurei

3D structure databases

SMRiQ48SR1. Positions 5-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000013583.
KOiK04564.
OMAiFWEVIAP.
OrthoDBiEOG63NMNT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q48SR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIILPELPY AYDALEPQFD AETMTLHHDK HHATYVANTN AALEKHPEIG
60 70 80 90 100
ENLEELLADV TKIPEDIRQA LINNGGGHLN HALFWELLSP EKQDVTPDVA
110 120 130 140 150
QAIDDAFGSF DAFKEQFTAA ATGRFGSGWA WLVVNKEGQL EITSTANQDT
160 170 180 190 200
PISEGKKPIL ALDVWEHAYY LNYRNVRPNY IKAFFEIINW KKVSELYQAA

K
Length:201
Mass (Da):22,667
Last modified:September 13, 2005 - v1
Checksum:i77005A39597B806F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000056 Genomic DNA. Translation: AAX72249.1.
RefSeqiYP_280604.1. NC_007296.1.

Genome annotation databases

EnsemblBacteriaiAAX72249; AAX72249; M28_Spy1139.
KEGGispb:M28_Spy1139.
PATRICi19745083. VBIStrPyo35950_1172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000056 Genomic DNA. Translation: AAX72249.1.
RefSeqiYP_280604.1. NC_007296.1.

3D structure databases

SMRiQ48SR1. Positions 5-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi319701.M28_Spy1139.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX72249; AAX72249; M28_Spy1139.
KEGGispb:M28_Spy1139.
PATRICi19745083. VBIStrPyo35950_1172.

Phylogenomic databases

HOGENOMiHOG000013583.
KOiK04564.
OMAiFWEVIAP.
OrthoDBiEOG63NMNT.

Enzyme and pathway databases

BioCyciSPYO319701:GHAD-1192-MONOMER.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity."
    Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M.
    J. Infect. Dis. 192:760-770(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS6180Imported.

Entry informationi

Entry nameiQ48SR1_STRPM
AccessioniPrimary (citable) accession number: Q48SR1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: April 29, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.