Reviewed, UniProtKB/Swiss-Prot Q48RW0 (LACB1_STRPM)

Names and origin

Protein names

Recommended name:
    Galactose-6-phosphate isomerase subunit lacB 1
    EC=5.3.1.26

Gene names

Name:	lacB1
Synonyms:	lacB.1
Ordered Locus Names:	M28_Spy1440

Organism

Streptococcus pyogenes serotype M28 [Complete proteome] [HAMAP]

Taxonomic identifier

319700 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-galactose 6-phosphate = D-tagatose 6-phosphate. HAMAP MF_01556
Pathway	Carbohydrate metabolism; galactose degradation; D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1. HAMAP MF_01556
Subunit structure	Heteromultimeric protein consisting of lacA and lacB By similarity.
Sequence similarities	Belongs to the lacAB/rpiB family.

Ontologies

Keywords
Biological process	Lactose metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: HAMAP
Molecular function	galactose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Galactose-6-phosphate isomerase subunit lacB 1 HAMAP MF_01556		PRO_0000208157

Sequences

	Sequence		Length	Mass (Da)
	Q48RW0-1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: 8D0A0048E53298F8	FASTA	171	18,926
	10 20 30 40 50 60 MKIAIGCDHI VTNEKMAVSD FLKSKGYDVI DCGTYDHTRT HYPIFGKKVG EAVVNGQADL 70 80 90 100 110 120 GVCICGTGVG INNAVNKVPG IRSALVRDMT TALYAKEELN ANVIGFGGKI TGELLMCDII 130 140 150 160 170 DAFIKAEYKE TEENKKLIAK IAHLESHHAN QEDPDFFTEF LEKWDRGEYH D

References

[1]

"Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity." Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M. J. Infect. Dis. 192:760-770(2005) [PubMed: 16088825] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS6180 / Serotype M28.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000056 Genomic DNA. Translation: AAX72550.1. Different initiation.
RefSeq	YP_280905.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3574160.
GenomeReviews	Gene locus M28_Spy1440 in contig CP000056_GR.
KEGG	spb:M28_Spy1440.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q48RW0.
OMA	Q48RW0. ETHHANQ.
Enzyme and pathway databases
BioCyc	SPYO319701:M28_SPY1440-MON.
Family and domain databases
HAMAP	MF_01556. [Tree]
InterPro	IPR004784. LacB. IPR003500. Rib/Gal_isomrase. [Graphical view]
Gene3D	G3DSA:3.40.1400.10. Rib/Gal_isomrase. 1 hit.
Pfam	PF02502. LacAB_rpiB. 1 hit. [Graphical view]
PIRSF	PIRSF005384. RpiB_LacA_B. 1 hit.
TIGRFAMs	TIGR01119. lacB. 1 hit. TIGR00689. rpiB_lacA_lacB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LACB1_STRPM

Accession

Primary (citable) accession number: Q48RW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 10, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)