ID   LACA1_STRPM             Reviewed;         141 AA.
AC   Q48RV9;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Galactose-6-phosphate isomerase subunit lacA 1;
DE            EC=5.3.1.26;
GN   Name=lacA1; Synonyms=lacA.1; OrderedLocusNames=M28_Spy1441;
OS   Streptococcus pyogenes serotype M28.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=319700;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS6180 / Serotype M28;
RX   PubMed=16088825; DOI=10.1086/430618;
RA   Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D.,
RA   Beres S.B., Lefebvre R.B., Musser J.M.;
RT   "Genome sequence of a serotype M28 strain of group A Streptococcus:
RT   potential new insights into puerperal sepsis and bacterial disease
RT   specificity.";
RL   J. Infect. Dis. 192:760-770(2005).
CC   -!- CATALYTIC ACTIVITY: D-galactose 6-phosphate = D-tagatose 6-
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose degradation; D-
CC       tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC   -!- SUBUNIT: Heteromultimeric protein consisting of lacA and lacB (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the lacAB/rpiB family.
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DR   EMBL; CP000056; AAX72551.1; -; Genomic_DNA.
DR   RefSeq; YP_280906.1; -.
DR   GeneID; 3574161; -.
DR   GenomeReviews; CP000056_GR; M28_Spy1441.
DR   KEGG; spb:M28_Spy1441; -.
DR   HOGENOM; Q48RV9; -.
DR   OMA; Q48RV9; HGNELKE.
DR   BioCyc; SPYO319701:M28_SPY1441-MON; -.
DR   GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:HAMAP.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-ph...; IEA:HAMAP.
DR   HAMAP; MF_01555; -; 1.
DR   InterPro; IPR004783; LacA.
DR   InterPro; IPR003500; Rib/Gal_isomrase.
DR   Gene3D; G3DSA:3.40.1400.10; Rib/Gal_isomrase; 1.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   TIGRFAMs; TIGR01118; lacA; 1.
DR   TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; Lactose metabolism.
FT   CHAIN         1    141       Galactose-6-phosphate isomerase subunit
FT                                lacA 1.
FT                                /FTId=PRO_0000208126.
SQ   SEQUENCE   141 AA;  15126 MW;  F6AB15F076C53F73 CRC64;
     MAIILGADAH GNALKELIKS FLQEEGYDII DVTDINSDFI DNTLAVAKAV NEAEGRLGIM
     VDAYGAGPFM VATKLKGMVA AEVSDERSAY MTRGHNNARM ITIGAEIVGP ELAKNIVKGF
     VTGPYDGGRH QIRVDMLNKM A
//