ID   Q48RP8_STRPM            Unreviewed;       404 AA.
AC   Q48RP8;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 2.
DT   24-JAN-2024, entry version 95.
DE   RecName: Full=alanine transaminase {ECO:0000256|ARBA:ARBA00026106};
DE            EC=2.6.1.2 {ECO:0000256|ARBA:ARBA00026106};
GN   OrderedLocusNames=M28_Spy1502 {ECO:0000313|EMBL:AAX72612.2};
OS   Streptococcus pyogenes serotype M28 (strain MGAS6180).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=319701 {ECO:0000313|EMBL:AAX72612.2, ECO:0000313|Proteomes:UP000009292};
RN   [1] {ECO:0000313|EMBL:AAX72612.2, ECO:0000313|Proteomes:UP000009292}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS6180 {ECO:0000313|EMBL:AAX72612.2,
RC   ECO:0000313|Proteomes:UP000009292};
RX   PubMed=16088825; DOI=10.1086/430618;
RA   Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B.,
RA   LeFebvre R.B., Musser J.M.;
RT   "Genome sequence of a serotype M28 strain of group A Streptococcus:
RT   potential new insights into puerperal sepsis and bacterial disease
RT   specificity.";
RL   J. Infect. Dis. 192:760-770(2005).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|ARBA:ARBA00007441}.
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DR   EMBL; CP000056; AAX72612.2; -; Genomic_DNA.
DR   RefSeq; WP_010922605.1; NC_007296.2.
DR   AlphaFoldDB; Q48RP8; -.
DR   KEGG; spb:M28_Spy1502; -.
DR   HOGENOM; CLU_017584_4_2_9; -.
DR   Proteomes; UP000009292; Chromosome.
DR   GO; GO:0004069; F:L-aspartate:2-oxoglutarate aminotransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   CDD; cd00609; AAT_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR43488; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR   PANTHER; PTHR43488:SF2; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000313|EMBL:AAX72612.2};
KW   Transferase {ECO:0000313|EMBL:AAX72612.2}.
FT   DOMAIN          34..394
FT                   /note="Aminotransferase class I/classII"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
SQ   SEQUENCE   404 AA;  45223 MW;  30D9D2499183A217 CRC64;
     MKIIEKSSKL EHVAYDIRGP VLDEANRMIA SGEKILRLNT GNPAAFGFEA PDEVIRDLIV
     NARLSEGYSD SKGIFSARKA IMQYCQLKGF PDVDIEDIYL GNGVSELISI SLQALLDNGD
     EVLVPMPDYP LWTACVSLGG GKAVHYLCDE EAGWYPDIAD IKSKITSRTK AIVVINPNNP
     TGALYPKEIL EDIVALAREH QLIIFADEIY DRLVMDGKEH IAIASLAPDV FCVSMNGLSK
     SHRIAGFRVG WMVLSGPKDH VKGYIEGLNM LANMRLCSNV LAQQVVQTSL GGHQSVDALL
     LPGGRIFEQR NFIYEAINAI PGLSAVKPEA GLYLFPKIDR QMYRIDDDEE FVLQLLKQEK
     VMLVHGRGFN WKDPDHFRIV YLPSVEELED VQEKITRVLY QYRR
//