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Q48RC8

- LACG_STRPM

UniProt

Q48RC8 - LACG_STRPM

Protein

6-phospho-beta-galactosidase

Gene

lacG

Organism
Streptococcus pyogenes serotype M28 (strain MGAS6180)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei160 – 1601Proton donorUniRule annotation
    Active sitei375 – 3751NucleophileUniRule annotation

    GO - Molecular functioni

    1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lactose catabolic process via tagatose-6-phosphate Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciSPYO319701:GHAD-1695-MONOMER.
    UniPathwayiUPA00542; UER00605.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phospho-beta-galactosidaseUniRule annotation (EC:3.2.1.85UniRule annotation)
    Alternative name(s):
    Beta-D-phosphogalactoside galactohydrolaseUniRule annotation
    Short name:
    PGALaseUniRule annotation
    P-beta-GalUniRule annotation
    Short name:
    PBGUniRule annotation
    Gene namesi
    Name:lacGUniRule annotation
    Ordered Locus Names:M28_Spy1622
    OrganismiStreptococcus pyogenes serotype M28 (strain MGAS6180)
    Taxonomic identifieri319701 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000009292: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4684686-phospho-beta-galactosidasePRO_0000260739Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi319701.M28_Spy1622.

    Structurei

    3D structure databases

    ProteinModelPortaliQ48RC8.
    SMRiQ48RC8. Positions 1-468.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2723.
    HOGENOMiHOG000088632.
    KOiK01220.
    OMAiNRWYLDP.
    OrthoDBiEOG60658J.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    HAMAPiMF_01574. LacG.
    InterProiIPR005928. 6P-beta-galactosidase.
    IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10353. PTHR10353. 1 hit.
    PfamiPF00232. Glyco_hydro_1. 1 hit.
    [Graphical view]
    PRINTSiPR00131. GLHYDRLASE1.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    TIGRFAMsiTIGR01233. lacG. 1 hit.
    PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q48RC8-1 [UniParc]FASTAAdd to Basket

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    MTKTLPKDFI FGGATAAYQA EGATHTDGKG PVAWDKYLED NYWYTAEPAS    50
    DFYNRYPVDL KLSEEFGVNG IRISIAWSRI FPTGKGEVNP KGVEYYHNLF 100
    AECHKRHVEP FVTLHHFDTP EALHSDGDFL NRENIEHFVN YAEFCFKEFS 150
    EVNYWTTFNE IGPIGDGQYL VGKFPPGIQY DLAKVFQSHH NMMVSHARAV 200
    KLFKDSGYSG EIGVVHALPT KYPFDANNPD DVRAAELEDI IHNKFILDAT 250
    YLGKYSDKTM EGVNHILEVN GGELDLREED FAALDAAKDL NDFLGINYYM 300
    SDWMQAFDGE TEIIHNGKGE KGSSKYQIKG VGRRKAPVDV PKTDWDWIIF 350
    PQGLYDQIMR VKADYPNYKK IYITENGLGY KDEFVDNTVY DDGRIDYVKK 400
    HLEVISDAIS DGANVKGYFM WSLMDVFSWS NGYEKRYGLF YVDFETQERY 450
    PKKSAYWYKK VAETQVIE 468
    Length:468
    Mass (Da):53,846
    Last modified:September 13, 2005 - v1
    Checksum:i76134ECAE5476CF7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000056 Genomic DNA. Translation: AAX72732.1.
    RefSeqiYP_281087.1. NC_007296.1.

    Genome annotation databases

    EnsemblBacteriaiAAX72732; AAX72732; M28_Spy1622.
    GeneIDi3574350.
    KEGGispb:M28_Spy1622.
    PATRICi19746111. VBIStrPyo35950_1666.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000056 Genomic DNA. Translation: AAX72732.1 .
    RefSeqi YP_281087.1. NC_007296.1.

    3D structure databases

    ProteinModelPortali Q48RC8.
    SMRi Q48RC8. Positions 1-468.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 319701.M28_Spy1622.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX72732 ; AAX72732 ; M28_Spy1622 .
    GeneIDi 3574350.
    KEGGi spb:M28_Spy1622.
    PATRICi 19746111. VBIStrPyo35950_1666.

    Phylogenomic databases

    eggNOGi COG2723.
    HOGENOMi HOG000088632.
    KOi K01220.
    OMAi NRWYLDP.
    OrthoDBi EOG60658J.

    Enzyme and pathway databases

    UniPathwayi UPA00542 ; UER00605 .
    BioCyci SPYO319701:GHAD-1695-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    HAMAPi MF_01574. LacG.
    InterProi IPR005928. 6P-beta-galactosidase.
    IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10353. PTHR10353. 1 hit.
    Pfami PF00232. Glyco_hydro_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00131. GLHYDRLASE1.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    TIGRFAMsi TIGR01233. lacG. 1 hit.
    PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity."
      Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M.
      J. Infect. Dis. 192:760-770(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS6180.

    Entry informationi

    Entry nameiLACG_STRPM
    AccessioniPrimary (citable) accession number: Q48RC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3