Q48RC2 (LACA2_STRPM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-6-phosphate isomerase subunit lacA 2
EC=5.3.1.26

Gene names

Name:	lacA2
Synonyms:	lacA.2
Ordered Locus Names:	M28_Spy1628

Organism

Streptococcus pyogenes serotype M28 [Complete proteome] [HAMAP]

Taxonomic identifier

319700 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-galactose 6-phosphate = D-tagatose 6-phosphate. HAMAP MF_01555
Pathway	Carbohydrate metabolism; D-galactose 6-phosphate degradation; D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1. HAMAP MF_01555
Subunit structure	Heteromultimeric protein consisting of lacA and lacB By similarity.
Sequence similarities	Belongs to the lacAB/rpiB family.

Ontologies

Keywords
Biological process	Lactose metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactose catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	galactose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Galactose-6-phosphate isomerase subunit lacA 2 HAMAP MF_01555		PRO_0000208127

Sequences

	Sequence		Length	Mass (Da)
	Q48RC2 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 2B4F7D3CEE6CFEF7	FASTA	142	15,413
	10 20 30 40 50 60 MAIIIGADKA GQELKEVIKD YLKEGKYEVV DVSENEVRDF VDTTLAVAKE VNASEDNLGI 70 80 90 100 110 120 VIDAYGVGSF MVATKIKGMV AAEVSDERSA YMTRGHNNAR IITLGSEISA PGIAKNIIKG 130 140 FVEGKYDGGR HQVRVDMLNK MC

References

[1]

"Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity." Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M. J. Infect. Dis. 192:760-770(2005) [PubMed: 16088825] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS6180 / Serotype M28.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000056 Genomic DNA. Translation: AAX72738.1.
RefSeq	YP_281093.1. NC_007296.1.
3D structure databases
ProteinModelPortal	Q48RC2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000031697; EBSTRP00000030529; EBSTRG00000031697.
GeneID	3574356.
GenomeReviews	Gene locus M28_Spy1628 in contig CP000056_GR.
KEGG	spb:M28_Spy1628.
PATRIC	19746123. VBIStrPyo35950_1672.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027285.
HOGENOM	HBG636953.
OMA	ARMITVG.
ProtClustDB	PRK08621.
Enzyme and pathway databases
BioCyc	SPYO319701:M28_SPY1628-MONOMER.
Family and domain databases
HAMAP	MF_01555. LacA. [Tree]
InterPro	IPR004783. Gal-6-P_isomerase_su_LacA. IPR003500. Rib/Gal_isomrase. [Graphical view]
Gene3D	G3DSA:3.40.1400.10. Rib/Gal_isomrase. 1 hit.
KO	K01819.
Pfam	PF02502. LacAB_rpiB. 1 hit. [Graphical view]
PIRSF	PIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAM	SSF89623. Rib/Gal_isomrase. 1 hit.
TIGRFAMs	TIGR01118. LacA. 1 hit. TIGR00689. RpiB_lacA_lacB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LACA2_STRPM

Accession

Primary (citable) accession number: Q48RC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program