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Q48QZ2

- FTHS2_STRPM

UniProt

Q48QZ2 - FTHS2_STRPM

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Protein
Formate--tetrahydrofolate ligase 2
Gene
fhs2, fhs.2, M28_Spy1758
Organism
Streptococcus pyogenes serotype M28 (strain MGAS6180)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO319701:GHAD-1833-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 2 (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase 2
Short name:
FHS 2
Short name:
FTHFS 2
Gene namesi
Name:fhs2
Synonyms:fhs.2
Ordered Locus Names:M28_Spy1758
OrganismiStreptococcus pyogenes serotype M28 (strain MGAS6180)
Taxonomic identifieri319701 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000009292: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligase 2UniRule annotation
PRO_0000199394Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi319701.M28_Spy1758.

Structurei

3D structure databases

ProteinModelPortaliQ48QZ2.
SMRiQ48QZ2. Positions 5-555.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiQLRYIND.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q48QZ2-1 [UniParc]FASTAAdd to Basket

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MVLSDIEIAN SVTMEPISKV ANQLGIDEEA LCLYGKYKAK IDARQLVALK    50
DKPDGKLILV TAISPTPAGE GKTTTSVGLV DALSAIGKKA VIALREPSLG 100
PVFGVKGGAA GGGHAQVVPM EDINLHFTGD FHAIGVANNL LAALIDNHIH 150
HGNSLGIDSR RITWKRVVDM NDRQLRHIVD GLQGKVNGVP REDGYDITVA 200
SEIMAILCLS ENISDLKARL EKIIIGYNYQ GEPVTAKDLK AGGALAALLK 250
DAIHPNLVQT LEHTPALIHG GPFANIAHGC NSVLATKLAL KYGDYAVTEA 300
GFGADLGAEK FIDIKCRMSG LRPAAVVLVA TIRALKMHGG VPKANLATEN 350
VQAVVDGLPN LDKHLANIQD VYGLPVVVAI NKFPLDTDAE LQAVYDACDK 400
RGVDVVISDV WANGGAGGRE LAEKVVALAE QDNQFCFVYE EDDSIETKLT 450
KIVTKVYGGK GIRLTPAAKR ELADLERLGF GNYPICMAKT QYSFSDDAKK 500
LGAPTDFTVT ISNLKVSAGA GFIVALTGAI MTMPGLPKVP ASETIDIDEE 550
GNITGLF 557
Length:557
Mass (Da):59,023
Last modified:September 13, 2005 - v1
Checksum:i400CE8FA4CBF19F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000056 Genomic DNA. Translation: AAX72868.1.
RefSeqiYP_281223.1. NC_007296.1.

Genome annotation databases

EnsemblBacteriaiAAX72868; AAX72868; M28_Spy1758.
GeneIDi3574469.
KEGGispb:M28_Spy1758.
PATRICi19746405. VBIStrPyo35950_1813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000056 Genomic DNA. Translation: AAX72868.1 .
RefSeqi YP_281223.1. NC_007296.1.

3D structure databases

ProteinModelPortali Q48QZ2.
SMRi Q48QZ2. Positions 5-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319701.M28_Spy1758.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX72868 ; AAX72868 ; M28_Spy1758 .
GeneIDi 3574469.
KEGGi spb:M28_Spy1758.
PATRICi 19746405. VBIStrPyo35950_1813.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi QLRYIND.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SPYO319701:GHAD-1833-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity."
    Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M.
    J. Infect. Dis. 192:760-770(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS6180.

Entry informationi

Entry nameiFTHS2_STRPM
AccessioniPrimary (citable) accession number: Q48QZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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