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Protein

Agmatine deiminase

Gene

aguA

Organism
Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mediates the hydrolysis of agmatine into N-carbamoylputrescine in the arginine decarboxylase (ADC) pathway of putrescine biosynthesis, a basic polyamine.UniRule annotation

Catalytic activityi

Agmatine + H2O = N-carbamoylputrescine + NH3.UniRule annotation

Pathwayi: putrescine biosynthesis via agmatine pathway

This protein is involved in step 1 of the subpathway that synthesizes N-carbamoylputrescine from agmatine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Agmatine deiminase (aguA)
This subpathway is part of the pathway putrescine biosynthesis via agmatine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-carbamoylputrescine from agmatine, the pathway putrescine biosynthesis via agmatine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei357 – 3571Amidino-cysteine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Polyamine biosynthesis

Enzyme and pathway databases

BioCyciPSAV264730:GKDE-153-MONOMER.
UniPathwayiUPA00534; UER00285.

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatine deiminaseUniRule annotation (EC:3.5.3.12UniRule annotation)
Alternative name(s):
Agmatine iminohydrolaseUniRule annotation
Gene namesi
Name:aguAUniRule annotation
Ordered Locus Names:PSPPH_0153
OrganismiPseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000551 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Agmatine deiminasePRO_1000070559Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi264730.PSPPH_0153.

Structurei

3D structure databases

ProteinModelPortaliQ48Q55.
SMRiQ48Q55. Positions 5-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the agmatine deiminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWY. Bacteria.
COG2957. LUCA.
HOGENOMiHOG000239346.
KOiK10536.
OMAiEVLLAWT.
OrthoDBiEOG6M3PB5.

Family and domain databases

HAMAPiMF_01841. Agmatine_deimin.
InterProiIPR017754. Agmatine_deiminase.
IPR007466. Peptidyl-Arg-deiminase_porph.
[Graphical view]
PfamiPF04371. PAD_porph. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03380. agmatine_aguA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48Q55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLNSTPRA DGFHMPAEWA PQTQVWMVWP ERPDNWRLGG KPAQAAHVAI
60 70 80 90 100
AKAIARFEPV TVAVSAAQYD NARARLDVPN IRVVEMSSND AWVRDSGPTF
110 120 130 140 150
VINERGEVRG VNWEFNAWGG FDGGLYAPWN LDSQLGSKVL EIERCPRYVT
160 170 180 190 200
KGFVLEGGSI HVDGEGTLIT TEECLLNRNR NPHLTREQIE AILGDYLAVD
210 220 230 240 250
KVVWLPDGLF NDETDGHVDN FCCYIRPGEV LLAWTDDPED PNYSRCHAAL
260 270 280 290 300
GILENTLDAK GRAFIVHKMP IPGPLFATEE ECAGVDQVHG SQERNPSVRL
310 320 330 340 350
AGSYVNFLIV NGGIIAPSFD DPMDEKAREL LQTLFPEHEV VMAPGRELLL
360
GGGNIHCLTQ QQPAPHKA
Length:368
Mass (Da):40,709
Last modified:September 13, 2005 - v1
Checksum:i2C8B49B941256F0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ33821.1.
RefSeqiWP_011167359.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ33821; AAZ33821; PSPPH_0153.
KEGGipsp:PSPPH_0153.
PATRICi19969300. VBIPseSyr78478_0173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ33821.1.
RefSeqiWP_011167359.1. NC_005773.3.

3D structure databases

ProteinModelPortaliQ48Q55.
SMRiQ48Q55. Positions 5-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264730.PSPPH_0153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ33821; AAZ33821; PSPPH_0153.
KEGGipsp:PSPPH_0153.
PATRICi19969300. VBIPseSyr78478_0173.

Phylogenomic databases

eggNOGiENOG4105DWY. Bacteria.
COG2957. LUCA.
HOGENOMiHOG000239346.
KOiK10536.
OMAiEVLLAWT.
OrthoDBiEOG6M3PB5.

Enzyme and pathway databases

UniPathwayiUPA00534; UER00285.
BioCyciPSAV264730:GKDE-153-MONOMER.

Family and domain databases

HAMAPiMF_01841. Agmatine_deimin.
InterProiIPR017754. Agmatine_deiminase.
IPR007466. Peptidyl-Arg-deiminase_porph.
[Graphical view]
PfamiPF04371. PAD_porph. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03380. agmatine_aguA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1448A / Race 6.

Entry informationi

Entry nameiAGUA_PSE14
AccessioniPrimary (citable) accession number: Q48Q55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 13, 2005
Last modified: November 11, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.