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Protein

Glutathione synthetase

Gene

gshB

Organism
Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.UniRule annotation

Pathwayi: glutathione biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes glutathione from L-cysteine and L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate--cysteine ligase (gshA)
  2. Glutathione synthetase (gshB)
This subpathway is part of the pathway glutathione biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glutathione from L-cysteine and L-glutamate, the pathway glutathione biosynthesis and in Sulfur metabolism.

GO - Molecular functioni

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processGlutathione biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00142; UER00210.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione synthetaseUniRule annotation (EC:6.3.2.3UniRule annotation)
Alternative name(s):
GSH synthetaseUniRule annotation
Short name:
GSH-SUniRule annotation
Short name:
GSHaseUniRule annotation
Glutathione synthaseUniRule annotation
Gene namesi
Name:gshBUniRule annotationImported
Ordered Locus Names:PSPPH_0478Imported
OrganismiPseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))Imported
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000551 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi264730.PSPPH_0478.

Structurei

3D structure databases

ProteinModelPortaliQ48P88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 311ATP-graspInterPro annotationAdd BLAST187

Sequence similaritiesi

Belongs to the prokaryotic GSH synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D7Z. Bacteria.
COG0189. LUCA.
HOGENOMiHOG000265022.
KOiK01920.
OMAiWMRKDPP.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00162. GSH_S. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR006284. Glut_synth_pro.
IPR004218. GSHS_ATP-bd.
IPR004215. GSHS_N.
IPR016185. PreATP-grasp_dom.
PANTHERiPTHR21621:SF10. PTHR21621:SF10. 1 hit.
PfamiView protein in Pfam
PF02955. GSH-S_ATP. 1 hit.
PF02951. GSH-S_N. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01380. glut_syn. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48P88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRLGIVMD PIERISYKKD SSLAMLLAAQ ERGWSLFYME QKDLYQDAGQ
60 70 80 90 100
ARARMKPLKV FADPAKWFEF EAEVDAGLDD LDVILMRKDL PFDMEFVYAT
110 120 130 140 150
YLLEQAERAG VLVVNKPQSL RDCNEKLFAT LFPQCTPPTL VSRRADIIRE
160 170 180 190 200
FAEKHGDVIL KPLDGMGGAS IFRHRAGDPN LSVILETLTA HGTQQIMAQG
210 220 230 240 250
YLPAIKDGDK RILMVDGEPV PYCLARIPAA GETRGNLAAG GRGEARPLSD
260 270 280 290 300
KDRWIAEQIG PTLREKGLLF VGLDVIGEHL TEINVTSPGG IREIDNAFGT
310
NIGGLLIDAI DKKLQARRG
Length:319
Mass (Da):35,280
Last modified:September 13, 2005 - v1
Checksum:i8C35B117D4BFAF96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ34205.1.
RefSeqiWP_011167499.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ34205; AAZ34205; PSPPH_0478.
KEGGipsp:PSPPH_0478.

Similar proteinsi

Entry informationi

Entry nameiQ48P88_PSE14
AccessioniPrimary (citable) accession number: Q48P88
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: September 27, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported