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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi387 – 394ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:PSPPH_0527
OrganismiPseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000551 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalUniRule annotationAdd BLAST21
Transmembranei82 – 102HelicalUniRule annotationAdd BLAST21
Transmembranei158 – 175HelicalUniRule annotationAdd BLAST18
Transmembranei180 – 199HelicalUniRule annotationAdd BLAST20
Transmembranei266 – 286HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716421 – 600Lipid A export ATP-binding/permease protein MsbAAdd BLAST600

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi264730.PSPPH_0527.

Structurei

3D structure databases

ProteinModelPortaliQ48P40.
SMRiQ48P40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 321ABC transmembrane type-1UniRule annotationAdd BLAST293
Domaini353 – 589ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48P40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSESSSTS SVKIYFRLLS YVRPHVGIFL LSIIGFVIFA STQPMLAGIL
60 70 80 90 100
KYFVDGLTNP EAVLFPNVPY LRELQLLQAV PLLIVLIAAW QGLGSFLGNY
110 120 130 140 150
FLAKVSLGLV HDLRVELFNK LLVLPNRYFD TTNSGHLISR ITFNVTMVTG
160 170 180 190 200
AATDAIKVVI REGLTVVFLF IYLLMMNWKL TLVMLAILPL IAVMVGSASK
210 220 230 240 250
KFRKQSKKIQ VAMGDVTHVA SETIQGYRVV RSFGGESYEQ NRFAQASDSN
260 270 280 290 300
TRKQLRMTKT GAIYTPMLQL VIYSAMAVLM FLVLFLRGDA TAGDLVAYIT
310 320 330 340 350
AAGLLPKPIR QLSEVSSTIQ KGVAGAESIF EQLDVEEEVD TGTIERDRVT
360 370 380 390 400
GHLEVKNLSF FYPQTERQVL NDISFSAAPG QMIALVGRSG SGKSTLANLI
410 420 430 440 450
PRFYGHEMGN ILLDGVEIND YRLRNLRKHI AQVNQNVTLF NDTIANNIAY
460 470 480 490 500
GDLAGAPRAD IEAAAADAYA KEFIDQLPQG FDTQVGENGV LLSGGQRQRL
510 520 530 540 550
AIARALLKNA PLLILDEATS ALDTESERHI QAALDHVMKG RTTLVIAHRL
560 570 580 590 600
STIEKADMIL VMDAGQIVER GTHTELLAQN GYYARLHAMG LDEPSPVGAV
Length:600
Mass (Da):65,827
Last modified:January 9, 2007 - v2
Checksum:i49E4B23A9AB54C75
GO

Sequence cautioni

The sequence AAZ36650 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ36650.1. Different initiation.
RefSeqiWP_019742283.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ36650; AAZ36650; PSPPH_0527.
KEGGipsp:PSPPH_0527.

Similar proteinsi

Entry informationi

Entry nameiMSBA_PSE14
AccessioniPrimary (citable) accession number: Q48P40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: June 7, 2017
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families