Q48NY1PNCB_PSE14Nicotinate phosphoribosyltransferaseNAPRTase6.3.4.21pncBPSPPH_0588Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)BacteriaPseudomonadotaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasWhole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola 1448A reveals divergence among pathovars in genes involved in virulence and transposition.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphateCofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.Belongs to the NAPRTase family.LigasePhosphoproteinPyridine nucleotide biosynthesisMSESAFSNRIVQSLLDTDFYKLTMMQAVLHNYPNVDVEWEFRCRNGEDLRPYLDEIRHQIELLCELSLSPEHLAFLERITFIKPDFLRFLGLFRFNTRYVKTSIENDELCIRLHGPWLHVILFEVPLLAIVSEVRNRHRYPDTLLSQARDRLYDKFEWLTTHATADELAELKVADFGTRRRFSYRVQEEMLGVLKNDFPGQFVGTSNVHLARQLDLKPLGTMAHEWIMAHQQLGPRLIDSQIAALDCWVREYRGLLGIALTDCITTDAFLNDFDLYFAKLFDGLRHDSGDPVKWAEKCISHYQKLGIDPMSKTLVFSDGLNLPKALDIFRALRGRINVSFGIGTNLTADIPGIAPMNMVLKMTACAGQAVAKISDEPGKTQCKDPNFVAYLRHVFKVPDLPSPEKPA
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License