ID   APAH_PSE14              Reviewed;         298 AA.
AC   Q48NT9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase, symmetrical;
DE            EC=3.6.1.41;
DE   AltName: Full=Diadenosine tetraphosphatase;
DE   AltName: Full=Ap4A hydrolase;
DE   AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase;
GN   Name=apaH; OrderedLocusNames=PSPPH_0631;
OS   Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=264730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16159782; DOI=10.1128/JB.187.18.6488-6498.2005;
RA   Joardar V., Lindeberg M., Jackson R.W., Selengut J., Dodson R.,
RA   Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S.,
RA   Gwinn Giglio M., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A.,
RA   Crabtree J., Creasy T., Davidsen T.M., Haft D.H., Zafar N., Zhou L.,
RA   Halpin R., Holley T., Khouri H.M., Feldblyum T.V., White O.,
RA   Fraser C.M., Chatterjee A.K., Cartinhour S., Schneider D.,
RA   Mansfield J.W., Collmer A., Buell R.;
RT   "Whole-genome sequence analysis of Pseudomonas syringae pv.
RT   phaseolicola 1448A reveals divergence among pathovars in genes
RT   involved in virulence and transposition.";
RL   J. Bacteriol. 187:6488-6498(2005).
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to
CC       yield ADP (By similarity).
CC   -!- CATALYTIC ACTIVITY: P(1),P(4)-bis(5'-adenosyl) tetraphosphate +
CC       H(2)O = 2 ADP.
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
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DR   EMBL; CP000058; AAZ37875.1; -; Genomic_DNA.
DR   RefSeq; YP_272930.1; -.
DR   GeneID; 3560545; -.
DR   GenomeReviews; CP000058_GR; PSPPH_0631.
DR   KEGG; psp:PSPPH_0631; -.
DR   NMPDR; fig|264730.3.peg.1030; -.
DR   HOGENOM; Q48NT9; -.
DR   OMA; Q48NT9; LVFGHWA.
DR   GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetr...; IEA:HAMAP.
DR   HAMAP; MF_00199; -; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; M-pesterase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   TIGRFAMs; TIGR00668; apaH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    298       Bis(5'-nucleosyl)-tetraphosphatase,
FT                                symmetrical.
FT                                /FTId=PRO_1000012074.
SQ   SEQUENCE   298 AA;  33470 MW;  263C99533E4B1C30 CRC64;
     MAVYAVGDLQ GCLEPLQCLL EHVHFNPEHD RLWLVGDLVN RGPQSLETLR YLYGLRESLV
     CVLGNHDLHL LAVARKHELL KKGDTLREIL EAPDRDELLG WVRRQKLMHY DAERNVAMVH
     AGIAPQWSLK KALKHAAEVE QALQEDQLYG AFLDGMYGNE PAKWDNDLQG VTRLRVITNY
     FTRMRFCTSD GKLDLKSKEG VETAIPGYAP WFSHPKRKTR ELKIIFGHWA ALEGRCDEPG
     VFALDSGCVW GGSMTLLNVD TLERHQCNCD AVGHAANGLV KSAQAGTATN PQAQEPRQ
//