Reviewed, UniProtKB/Swiss-Prot Q48NT9 (APAH_PSE14)

Names and origin

Protein names

Recommended name:
    Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
    EC=3.6.1.41
Alternative name(s):
    Diadenosine tetraphosphatase
    Ap4A hydrolase
    Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase

Gene names

Name:	apaH
Ordered Locus Names:	PSPPH_0631

Organism

Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6) [Complete proteome] [HAMAP]

Taxonomic identifier

264730 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_1000012074

Sequences

	Sequence		Length	Mass (Da)
	Q48NT9-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 263C99533E4B1C30	FASTA	298	33,470
	10 20 30 40 50 60 MAVYAVGDLQ GCLEPLQCLL EHVHFNPEHD RLWLVGDLVN RGPQSLETLR YLYGLRESLV 70 80 90 100 110 120 CVLGNHDLHL LAVARKHELL KKGDTLREIL EAPDRDELLG WVRRQKLMHY DAERNVAMVH 130 140 150 160 170 180 AGIAPQWSLK KALKHAAEVE QALQEDQLYG AFLDGMYGNE PAKWDNDLQG VTRLRVITNY 190 200 210 220 230 240 FTRMRFCTSD GKLDLKSKEG VETAIPGYAP WFSHPKRKTR ELKIIFGHWA ALEGRCDEPG 250 260 270 280 290 VFALDSGCVW GGSMTLLNVD TLERHQCNCD AVGHAANGLV KSAQAGTATN PQAQEPRQ

References

[1]

"Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola 1448A reveals divergence among pathovars in genes involved in virulence and transposition." Joardar V., Lindeberg M., Jackson R.W., Selengut J., Dodson R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn Giglio M., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Crabtree J., Creasy T., Davidsen T.M., Haft D.H. , Zafar N., Zhou L., Halpin R., Holley T., Khouri H.M., Feldblyum T.V., White O., Fraser C.M., Chatterjee A.K., Cartinhour S., Schneider D., Mansfield J.W., Collmer A., Buell R. J. Bacteriol. 187:6488-6498(2005) [PubMed: 16159782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000058 Genomic DNA. Translation: AAZ37875.1.
RefSeq	YP_272930.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3560545.
GenomeReviews	Gene locus PSPPH_0631 in contig CP000058_GR.
KEGG	psp:PSPPH_0631.
NMPDR	fig|264730.3.peg.1030.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q48NT9.
OMA	Q48NT9. LVFGHWA.
Family and domain databases
HAMAP	MF_00199. [Tree]
InterPro	IPR004617. ApaH. IPR004843. M-pesterase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. apaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_PSE14

Accession

Primary (citable) accession number: Q48NT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)