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Q48ME3

- GCSP_PSE14

UniProt

Q48ME3 - GCSP_PSE14

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, PSPPH_1162
Organism
Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPSAV264730:GKDE-1164-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:PSPPH_1162
OrganismiPseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000551: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000227120Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei706 – 7061N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi264730.PSPPH_1162.

Structurei

3D structure databases

ProteinModelPortaliQ48ME3.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48ME3-1 [UniParc]FASTAAdd to Basket

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MTDRIELTTA NEFIARHIGP RAADEQAMLQ TLGFDSIEAL SESVIPESIK    50
GTSVLNLPAG QSEADALASI KAIASKNQLF KTYIGQGYYN THTPAPILRN 100
LLENPAWYTA YTPYQPEISQ GRLESLLNFQ TLISDLTGLP IANASLLDEA 150
TAAAEAMTFC KRLSKNKGSQ QFFASSHCHP QTLDVLRTRA EPLGITVVVA 200
DEAELGDVSD YFGALLQYPA SNGDVFDYRE LVERFHAANA LVAVAADLLA 250
LTLLTPPGEF GADVAIGSAQ RFGVPLGFGG PHAAYFSTRD AFKRDMPGRL 300
VGVSVDRHGK QALRLAMQTR EQHIRREKAT SNICTAQVLL ANIASMYAVY 350
HGPRGLTQIA KRVHQLTAIL AEGLSTLGLK AEQAFFFDSL TLNTGSRTAA 400
LHAAARARHI NLREIDDQHL GLSLDETTSQ SAVETLWEIF ASDGQNLPDF 450
TALAASVPSR LPATLLRQSA ILSHPVFNRY HSETELMRYL RKLADKDLAL 500
DRTMIPLGSC TMKLNAASEM IPVTWAEFGN LHPFAPAEQS TGYQQLTDEL 550
EAMLCAATGY DAISLQPNAG SQGEYAGLLA IRAYHQSRGD EHRDICLIPS 600
SAHGTNPATA NMAGMRVVVT ACDARGNVDI EDLRAKTVQH RDQLAAIMIT 650
YPSTHGVFEE GIREICGIVH DNGGQVYIDG ANMNAMVGLC APGKFGGDVS 700
HLNLHKTFCI PHGGGGPGVG PIGVKSHLAP FMPGHARMER KEGAVCAAPF 750
GSASILPITW MYIRMMGGEG LKRASQLAIL NANYISRRLE EHYPVLYTGT 800
NGLVAHECIL DLRPIKDSSG ISVDDVAKRL IDFGFHAPTM SFPVAGTLMI 850
EPTESESREE LDRFCDAMIK IREEIRAVEN GTLDKDDNPL KNAPHTAAEI 900
VGQWSHPYSR EQAVYPVDSL IENKYWPPVG RVDNVFGDRN LVCACPSIES 950
YQEA 954
Length:954
Mass (Da):103,674
Last modified:September 13, 2005 - v1
Checksum:i0797995B634B9355
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000058 Genomic DNA. Translation: AAZ34685.1.
RefSeqiYP_273429.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ34685; AAZ34685; PSPPH_1162.
GeneIDi3557245.
KEGGipsp:PSPPH_1162.
PATRICi19971424. VBIPseSyr78478_1219.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000058 Genomic DNA. Translation: AAZ34685.1 .
RefSeqi YP_273429.1. NC_005773.3.

3D structure databases

ProteinModelPortali Q48ME3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264730.PSPPH_1162.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ34685 ; AAZ34685 ; PSPPH_1162 .
GeneIDi 3557245.
KEGGi psp:PSPPH_1162.
PATRICi 19971424. VBIPseSyr78478_1219.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PSAV264730:GKDE-1164-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1448A / Race 6.

Entry informationi

Entry nameiGCSP_PSE14
AccessioniPrimary (citable) accession number: Q48ME3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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