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Q48ME3

- GCSP_PSE14

UniProt

Q48ME3 - GCSP_PSE14

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPSAV264730:GKDE-1164-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:PSPPH_1162
OrganismiPseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000551: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_0000227120Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei706 – 7061N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi264730.PSPPH_1162.

Structurei

3D structure databases

ProteinModelPortaliQ48ME3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48ME3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MTDRIELTTA NEFIARHIGP RAADEQAMLQ TLGFDSIEAL SESVIPESIK
60 70 80 90 100
GTSVLNLPAG QSEADALASI KAIASKNQLF KTYIGQGYYN THTPAPILRN
110 120 130 140 150
LLENPAWYTA YTPYQPEISQ GRLESLLNFQ TLISDLTGLP IANASLLDEA
160 170 180 190 200
TAAAEAMTFC KRLSKNKGSQ QFFASSHCHP QTLDVLRTRA EPLGITVVVA
210 220 230 240 250
DEAELGDVSD YFGALLQYPA SNGDVFDYRE LVERFHAANA LVAVAADLLA
260 270 280 290 300
LTLLTPPGEF GADVAIGSAQ RFGVPLGFGG PHAAYFSTRD AFKRDMPGRL
310 320 330 340 350
VGVSVDRHGK QALRLAMQTR EQHIRREKAT SNICTAQVLL ANIASMYAVY
360 370 380 390 400
HGPRGLTQIA KRVHQLTAIL AEGLSTLGLK AEQAFFFDSL TLNTGSRTAA
410 420 430 440 450
LHAAARARHI NLREIDDQHL GLSLDETTSQ SAVETLWEIF ASDGQNLPDF
460 470 480 490 500
TALAASVPSR LPATLLRQSA ILSHPVFNRY HSETELMRYL RKLADKDLAL
510 520 530 540 550
DRTMIPLGSC TMKLNAASEM IPVTWAEFGN LHPFAPAEQS TGYQQLTDEL
560 570 580 590 600
EAMLCAATGY DAISLQPNAG SQGEYAGLLA IRAYHQSRGD EHRDICLIPS
610 620 630 640 650
SAHGTNPATA NMAGMRVVVT ACDARGNVDI EDLRAKTVQH RDQLAAIMIT
660 670 680 690 700
YPSTHGVFEE GIREICGIVH DNGGQVYIDG ANMNAMVGLC APGKFGGDVS
710 720 730 740 750
HLNLHKTFCI PHGGGGPGVG PIGVKSHLAP FMPGHARMER KEGAVCAAPF
760 770 780 790 800
GSASILPITW MYIRMMGGEG LKRASQLAIL NANYISRRLE EHYPVLYTGT
810 820 830 840 850
NGLVAHECIL DLRPIKDSSG ISVDDVAKRL IDFGFHAPTM SFPVAGTLMI
860 870 880 890 900
EPTESESREE LDRFCDAMIK IREEIRAVEN GTLDKDDNPL KNAPHTAAEI
910 920 930 940 950
VGQWSHPYSR EQAVYPVDSL IENKYWPPVG RVDNVFGDRN LVCACPSIES

YQEA
Length:954
Mass (Da):103,674
Last modified:September 13, 2005 - v1
Checksum:i0797995B634B9355
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ34685.1.
RefSeqiYP_273429.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ34685; AAZ34685; PSPPH_1162.
GeneIDi3557245.
KEGGipsp:PSPPH_1162.
PATRICi19971424. VBIPseSyr78478_1219.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ34685.1 .
RefSeqi YP_273429.1. NC_005773.3.

3D structure databases

ProteinModelPortali Q48ME3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264730.PSPPH_1162.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ34685 ; AAZ34685 ; PSPPH_1162 .
GeneIDi 3557245.
KEGGi psp:PSPPH_1162.
PATRICi 19971424. VBIPseSyr78478_1219.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PSAV264730:GKDE-1164-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1448A / Race 6.

Entry informationi

Entry nameiGCSP_PSE14
AccessioniPrimary (citable) accession number: Q48ME3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3