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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf1

Organism
Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491NADPUniRule annotation
Binding sitei145 – 1451NADPUniRule annotation
Binding sitei175 – 1751SubstrateUniRule annotation
Binding sitei179 – 1791SubstrateUniRule annotation
Binding sitei213 – 2131SubstrateUniRule annotation
Binding sitei232 – 2321SubstrateUniRule annotation
Active sitei237 – 2371Proton acceptorUniRule annotation
Binding sitei337 – 3371SubstrateUniRule annotation
Binding sitei342 – 3421SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi92 – 932NADPUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: JCVI
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glucose metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: JCVI
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciPSAV264730:GKDE-1190-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwf1Imported
Synonyms:zwfUniRule annotation
Ordered Locus Names:PSPPH_1188Imported
OrganismiPseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)Imported
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000551 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi264730.PSPPH_1188.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiHNLQTTK.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48MB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLITVEPCT FALFGALGDL AVRKLFPALY QLDRAGLLHE DTKILALARE
60 70 80 90 100
PGDEQSHLAY IEKSMRRFIP EAELEPDNLG RFLARLSYLH VDFLKAEDYV
110 120 130 140 150
ALAERVGTAE TLIAYFATPA SVYGAICENL ASVNLAERTR AVLEKPIGHD
160 170 180 190 200
LASSRRVNDA VAQFFPENRV YRIDHYLGKD TVQNLIALRF ANSLFETQWN
210 220 230 240 250
QNHISHVEIT VAEKVGIEGR WGYFDQAGQL RDMIQNHLLQ LLCLIAMDPP
260 270 280 290 300
SDLSADSIRD EKVKVLKALA PFTPERLATQ VVRGQYTAGY SEGKAVPGYL
310 320 330 340 350
EEENSNTQSD TETFVALRAD IRNWRWSGTP FYLRTGKRMP QKMSQIVIHF
360 370 380 390 400
KEPPHYIFAP EQRLQISNRL IIRLQPDEGI SLQVMTKDQG LDKGMQLRSG
410 420 430 440 450
PLQLNFSDTY RSARVPDAYE RLLLEVMRGN QNLFVRKDEI EYAWQWCDQL
460 470 480
IAGWKKAGDA PKPYPAGTWG PMSSIALITR DGRSWYGDM
Length:489
Mass (Da):55,509
Last modified:September 13, 2005 - v1
Checksum:iC107E61C93470596
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ33960.1.
RefSeqiYP_273455.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ33960; AAZ33960; PSPPH_1188.
KEGGipsp:PSPPH_1188.
PATRICi19971478. VBIPseSyr78478_1246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ33960.1.
RefSeqiYP_273455.1. NC_005773.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264730.PSPPH_1188.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ33960; AAZ33960; PSPPH_1188.
KEGGipsp:PSPPH_1188.
PATRICi19971478. VBIPseSyr78478_1246.

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiHNLQTTK.
OrthoDBiEOG61308Z.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.
BioCyciPSAV264730:GKDE-1190-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1448A / Race 6Imported.

Entry informationi

Entry nameiQ48MB7_PSE14
AccessioniPrimary (citable) accession number: Q48MB7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: April 29, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.