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Q48KZ0

- CLPP_PSE14

UniProt

Q48KZ0 - CLPP_PSE14

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Protein

ATP-dependent Clp protease proteolytic subunit

Gene
clpP, PSPPH_1698
Organism
Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei114 – 1141Nucleophile By similarity
Active sitei139 – 1391 By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciPSAV264730:GKDE-1701-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunit (EC:3.4.21.92)
Alternative name(s):
Endopeptidase Clp
Gene namesi
Name:clpP
Ordered Locus Names:PSPPH_1698
OrganismiPseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000551: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213ATP-dependent Clp protease proteolytic subunitUniRule annotationPRO_0000226461Add
BLAST

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes By similarity.

Protein-protein interaction databases

STRINGi264730.PSPPH_1698.

Structurei

3D structure databases

ProteinModelPortaliQ48KZ0.
SMRiQ48KZ0. Positions 19-209.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.

Phylogenomic databases

eggNOGiCOG0740.
HOGENOMiHOG000285833.
KOiK01358.
OMAiKGERSFD.
OrthoDBiEOG6Z3KQ0.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00493. clpP. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q48KZ0-1 [UniParc]FASTAAdd to Basket

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MSRNSYIQQN SDIQAAGGLV PMVIEQSARG ERAYDIYSRL LKERVIFMVG    50
PVEDYMANLI AAQLLFLEAE NPDKDIHLYI NSPGGSVTAG MSIYDTMQFI 100
KPDVSTICIG QACSMGAFLL AGGAEGKRHC LPNSRMMIHQ PLGGFQGQAS 150
DIDIHAKEIL HIRHRLNSLL AHHTGQSLET IERDTERDNF MSAERAAEYG 200
LIDSVINKRQ MPA 213
Length:213
Mass (Da):23,578
Last modified:September 13, 2005 - v1
Checksum:i46D77E6981A5B206
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000058 Genomic DNA. Translation: AAZ33449.1.
RefSeqiYP_273935.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ33449; AAZ33449; PSPPH_1698.
GeneIDi3555975.
KEGGipsp:PSPPH_1698.
PATRICi19972571. VBIPseSyr78478_1781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000058 Genomic DNA. Translation: AAZ33449.1 .
RefSeqi YP_273935.1. NC_005773.3.

3D structure databases

ProteinModelPortali Q48KZ0.
SMRi Q48KZ0. Positions 19-209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264730.PSPPH_1698.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ33449 ; AAZ33449 ; PSPPH_1698 .
GeneIDi 3555975.
KEGGi psp:PSPPH_1698.
PATRICi 19972571. VBIPseSyr78478_1781.

Phylogenomic databases

eggNOGi COG0740.
HOGENOMi HOG000285833.
KOi K01358.
OMAi KGERSFD.
OrthoDBi EOG6Z3KQ0.

Enzyme and pathway databases

BioCyci PSAV264730:GKDE-1701-MONOMER.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
HAMAPi MF_00444. ClpP.
InterProi IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view ]
PANTHERi PTHR10381. PTHR10381. 1 hit.
Pfami PF00574. CLP_protease. 1 hit.
[Graphical view ]
PRINTSi PR00127. CLPPROTEASEP.
SUPFAMi SSF52096. SSF52096. 1 hit.
TIGRFAMsi TIGR00493. clpP. 1 hit.
PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1448A / Race 6.

Entry informationi

Entry nameiCLPP_PSE14
AccessioniPrimary (citable) accession number: Q48KZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi