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Q48IH8 (NUDC_PSE14) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH pyrophosphatase
EC=3.6.1.22
Gene names
Name:nudC
Ordered Locus Names:PSPPH_2609
OrganismPseudomonas syringae pv. phaseolicola (strain 1448A / Race 6) [Complete proteome] [HAMAP]
Taxonomic identifier264730 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas syringae pv. savastanoi

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

NAD+ + H2O = AMP + NMN. HAMAP MF_00297

Cofactor

Divalent metal cations. Magnesium or manganese By similarity.

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00297

Subunit structure

Homodimer By similarity. HAMAP MF_00297

Sequence similarities

Belongs to the Nudix hydrolase family. NudC subfamily.

Contains 1 nudix hydrolase domain.

Ontologies

Keywords
   LigandMagnesium
Manganese
Metal-binding
NAD
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionNAD+ diphosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278NADH pyrophosphatase HAMAP MF_00297
PRO_0000232118

Regions

Domain141 – 264124Nudix hydrolase
Motif175 – 19622Nudix box HAMAP MF_00297

Sites

Metal binding1141Zinc By similarity
Metal binding1171Zinc By similarity
Metal binding1321Zinc By similarity
Metal binding1901Divalent metal cation By similarity
Metal binding1941Divalent metal cation By similarity

Sequences

Sequence LengthMass (Da)Tools
Q48IH8 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 5D2D23DE5202D67F

FASTA27831,068
        10         20         30         40         50         60 
MAHPERWTTA VLDVEADGGL AVVQSDQGFL LDTNGAMFPR GWLAGLDLPV QSEHGIGYFE 

        70         80         90        100        110        120 
GEPVYLLVLE RSVAVEGCSW QGLRQFMLEG DFAVFQMLGY AAQVSTWARE HRFCGACGRA 

       130        140        150        160        170        180 
TVQIRGERAM FCEHDNLRLY PRISPSMIVL VTRGDEILLA RSPRFVTGMY SALAGFVEPG 

       190        200        210        220        230        240 
ESAEDCVHRE VMEEVQVRIK NLKYMGSQCW PFPHSMMLGF HAEYDSGDIV PQAEEIEDAR 

       250        260        270 
WFHIDDLPPL PANRSIARYL IEAYLAERSG APEPVLPG

« Hide

References

[1]"Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola 1448A reveals divergence among pathovars in genes involved in virulence and transposition."
Joardar V., Lindeberg M., Jackson R.W., Selengut J., Dodson R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn Giglio M., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Crabtree J., Creasy T., Davidsen T.M., Haft D.H. expand/collapse author list , Zafar N., Zhou L., Halpin R., Holley T., Khouri H.M., Feldblyum T.V., White O., Fraser C.M., Chatterjee A.K., Cartinhour S., Schneider D., Mansfield J.W., Collmer A., Buell R.
J. Bacteriol. 187:6488-6498(2005) [PubMed: 16159782] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1448A / Race 6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000058 Genomic DNA. Translation: AAZ35769.1.
RefSeqYP_274803.1. NC_005773.3.

3D structure databases

ProteinModelPortalQ48IH8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ48IH8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3558368.
GenomeReviewsGene locus PSPPH_2609 in contig CP000058_GR.
KEGGpsp:PSPPH_2609.
NMPDRfig|264730.3.peg.2595.
PATRIC19974513. VBIPseSyr78478_2739.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2816.
HOGENOMHBG736436.
OMAYPRISPS.
PhylomeDBQ48IH8.
ProtClustDBPRK00241.

Family and domain databases

HAMAPMF_00297. Nudix_NudC.
[Tree]
InterProIPR015375. NADH_PPase-like_N.
IPR022925. NADH_pyroPase_NudC.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR015376. Znr_NADH_PPase.
[Graphical view]
Gene3DG3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
KOK03426.
PfamPF00293. NUDIX. 1 hit.
PF09296. NUDIX-like. 1 hit.
PF09297. zf-NADH-PPase. 1 hit.
[Graphical view]
SUPFAMSSF55811. NUDIX_hydrolase. 2 hits.
PROSITEPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUDC_PSE14
AccessionPrimary (citable) accession number: Q48IH8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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