Reviewed, UniProtKB/Swiss-Prot Q48IH8 (NUDC_PSE14)

Names and origin

Protein names

Recommended name:
    NADH pyrophosphatase
    EC=3.6.1.22

Gene names

Name:	nudC
Ordered Locus Names:	PSPPH_2609

Organism

Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6) [Complete proteome] [HAMAP]

Taxonomic identifier

264730 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	NAD+ + H2O = AMP + NMN. HAMAP MF_00297
Cofactor	Divalent ions. Manganese or magnesium By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. NudC subfamily.

Ontologies

Keywords
Ligand	Magnesium Manganese NAD
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	NAD+ diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	NADH pyrophosphatase HAMAP MF_00297		PRO_0000232118
Regions
	Motif	175 – 196	22	Nudix box HAMAP MF_00297

Sequences

	Sequence		Length	Mass (Da)
	Q48IH8-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 5D2D23DE5202D67F	FASTA	278	31,068
	10 20 30 40 50 60 MAHPERWTTA VLDVEADGGL AVVQSDQGFL LDTNGAMFPR GWLAGLDLPV QSEHGIGYFE 70 80 90 100 110 120 GEPVYLLVLE RSVAVEGCSW QGLRQFMLEG DFAVFQMLGY AAQVSTWARE HRFCGACGRA 130 140 150 160 170 180 TVQIRGERAM FCEHDNLRLY PRISPSMIVL VTRGDEILLA RSPRFVTGMY SALAGFVEPG 190 200 210 220 230 240 ESAEDCVHRE VMEEVQVRIK NLKYMGSQCW PFPHSMMLGF HAEYDSGDIV PQAEEIEDAR 250 260 270 WFHIDDLPPL PANRSIARYL IEAYLAERSG APEPVLPG

References

[1]

"Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola 1448A reveals divergence among pathovars in genes involved in virulence and transposition." Joardar V., Lindeberg M., Jackson R.W., Selengut J., Dodson R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn Giglio M., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Crabtree J., Creasy T., Davidsen T.M., Haft D.H. , Zafar N., Zhou L., Halpin R., Holley T., Khouri H.M., Feldblyum T.V., White O., Fraser C.M., Chatterjee A.K., Cartinhour S., Schneider D., Mansfield J.W., Collmer A., Buell R. J. Bacteriol. 187:6488-6498(2005) [PubMed: 16159782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000058 Genomic DNA. Translation: AAZ35769.1.
RefSeq	YP_274803.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3558368.
GenomeReviews	Gene locus PSPPH_2609 in contig CP000058_GR.
KEGG	psp:PSPPH_2609.
NMPDR	fig|264730.3.peg.2595.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q48IH8.
OMA	Q48IH8. TWAREHR.
Family and domain databases
HAMAP	MF_00297. [Tree]
InterPro	IPR015375. NADH_PPase-like_N. IPR000086. NUDIX_hydrolase_core. IPR015376. Znr_NADH_PPase. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
Pfam	PF00293. NUDIX. 1 hit. PF09296. NUDIX-like. 1 hit. PF09297. zf-NADH-PPase. 1 hit. [Graphical view]
PROSITE	PS00893. NUDIX. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUDC_PSE14

Accession

Primary (citable) accession number: Q48IH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)